Reduced information processing speed as primum movens for cognitive decline in MS

Schependom, Jeroen Van; D'hooghe, Marie B; Cleynhens, Krista; D'hooge, Mieke; Haelewyck, Marie-Claire; Keyser, Jacques De; Nagels, Guy

doi:10.1177/1352458514537012

Cited by 73 publications

(60 citation statements)

References 37 publications

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“…Furthermore, in order to assess the magnitude of these changes, the effect size of POST vs. PRE difference in PwMS cognitive performance was calculated by means of Cohen d method (Cohen 1988) and interpreted according to Sawilowsky descriptors (d = 0.01: very small, d = 0.20: small, d = 0.50: medium, d = 0.80: large, d = 1.20: very large, or d = 2.0: huge) (Sawilowsky 2009). Mean percentage change, calculated as ((POST score -PRE score) / PRE score) × 100, was computed for SDMT and PASAT-3, i.e., the tests investigating information processing speed which was shown to be the cognitive domain most widely affected by MS and the first cognitive deficit to emerge in PwMS (Van Schependom et al 2015).…”

Section: Cognitive Performance Evaluationmentioning

confidence: 99%

Brain activity pattern changes after adaptive working memory training in multiple sclerosis

Bonzano

Pedullà

Pardini

et al. 2018

Brain Imaging and Behavior

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Cognitive impairment and related abnormal brain activity are common in people with multiple sclerosis (PwMS). Adaptive training based on working memory (WM) has been shown to ameliorate cognitive symptoms, although the effects at a neural level are unclear. The aim of this study was to expand the existing research on the effects of an adaptive WM rehabilitative intervention on brain functional activity in PwMS. A sample of eighteen PwMS performed an 8-week home-based cognitive rehabilitation treatment based on adaptive WM training. PwMS were assessed before and after treatment using a validated neuropsychological battery and undergoing an fMRI session while carrying out a cognitive task (i.e., Paced Visual Serial Addition Test -PVSAT). fMRI activations were compared to the activation pattern elicited by eighteen matched healthy subjects performing the same task. At baseline, we found abnormal brain activity during PVSAT in PwMS when compared to healthy subjects, with a pattern including several bilateral activation clusters. Following rehabilitation, PwMS improved cognitive performance, as evaluated by the neuropsychological battery, and showed a different activation map with clusters mainly located in the right cerebellum and in the left hemisphere. The only significant cluster in the right hemisphere was located in the inferior parietal lobule, and the BOLD signal extracted in this area significantly correlated with cognitive performance both before and after the treatment. We suggest that WM training can improve the cognitive performance and reduce the abnormal activation of PwMS by partially maintaining or even restoring brain cognitive function.

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Section: Cognitive Performance Evaluationmentioning

confidence: 99%

Brain activity pattern changes after adaptive working memory training in multiple sclerosis

Bonzano

Pedullà

Pardini

et al. 2018

Brain Imaging and Behavior

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“…Cognitive impairment (CI) is very common in MS, with prevalence rates ranging from 43% to 70% (Peyser et al, 1990;Rao et al, 1991). Particularly information processing speed (Van Schependom et al, 2014), working memory (D'Esposito et al, 1996), attention and visuospatial abilities (Chiaravalloti and DeLuca, 2008) have been shown to be affected in persons with MS (PwMS). These cognitive problems have a detrimental effect on the employment status, social and vocational activities, and mental health of PwMS.…”

Section: Introductionmentioning

confidence: 99%

Does including the full CVLT-II and BVMT-R improve BICAMS? Evidence from a Belgian (Dutch) validation study

Gielen

Eelen²,

Schependom

et al. 2017

Multiple Sclerosis and Related Disorders

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“…Early stages of MS have been associated with significant cognitive impairment focused on attention, executive functions, memory, and learning [16]. Information processing in particular is the cognitive domain most widely affected by MS and is notably the first deficit to emerge [17–19]. MS patients with progressive disease course, especially secondary progressive, can also experience a range of cognitive deficits and associated disability [20].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

Alosaimi

AlMulhem

Moscovici

et al. 2017

Behavioural Neurology

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Introduction Multiple sclerosis (MS) is a common disorder in some regions of the world, with over 2.3 million people diagnosed worldwide. Cognitive impairment is one of the earliest symptoms to present in the course of the disease and can cause significant morbidity. We proposed a study to explore the psychosocial predictors of cognitive impairment in MS patients in Saudi Arabia, a previously unexplored patient population. Methods Demographic data, depression scale (PHQ9), symptom burden (PHQ15), anxiety (GAD7), disease duration, and Montreal Cognitive Assessment (MOCA) scores were collected from 195 patients in a neurology clinic in Ryiadh, Saudi Arabia. Univariate and multiple regression analyses were conducted to identify variables that are significantly associated with cognitive impairment. Results Variables that were identified to be significantly associated with cognition, p < 0.05, were education level, disease duration, and family history. Discussion Both education level and disease duration were variables identified in previous studies. We showed family history to be a significant variable, and no association was found with depression or anxiety, which is unique to our study population. Conclusions We identified several psychosocial predictors that are associated with cognition in our patient population. It was also noted that a difference exists between patient populations, highlighting the need for further studies in specific geographical regions.

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Reduced information processing speed as primum movens for cognitive decline in MS

Abstract: In conclusion, IPS is the cognitive domain not only most widely affected by MS but it is also the first cognitive deficit to emerge in MS.

Cited by 73 publications

References 37 publications

Brain activity pattern changes after adaptive working memory training in multiple sclerosis

Brain activity pattern changes after adaptive working memory training in multiple sclerosis

Does including the full CVLT-II and BVMT-R improve BICAMS? Evidence from a Belgian (Dutch) validation study

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

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