Reduced kidney function and hypertension in adolescents with low birth weight, NHANES 1999–2016

Brathwaite, Kaye E.; Levy, Rebecca V.; Sarathy, Harini; Agalliu, Ilir; Johns, Tanya S.; Reidy, Kimberly; Fadrowski, Jeffrey J.; Schwartz, George J.; Kaskel, Frederick J.; Melamed, Michal L.

doi:10.1007/s00467-023-05958-2

Cited by 6 publications

(2 citation statements)

References 52 publications

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“…Low birth weight was defined as weight <2500 g [ 18 ]. The weight status of children and adolescents aged 2-17 years old was assessed by the BMI Z-score.…”

Section: Methodsmentioning

confidence: 99%

Multivitamin consumption and childhood asthma: a cross-sectional study of the NHANES database

Zhang,

Xu,

et al. 2024

BMC Pediatr

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Background Dietary intakes of vitamins are associated with asthma. However, previous studies mainly explored the association between a single vitamin intake and asthma, which did not take the multivitamins into consideration. Herein, this study aims to explore the overall effect of dietary multivitamins consumption on childhood asthma. Methods Data of children and adolescents (aged 2-17 years old) were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2015-2018 in this cross-sectional study. Weighted univariate logistic regression analysis was used to screen covariates. The association between multivitamins (including vitamin A, C, D, E, B1, B2, B6, B12, K, niacin, folic acid, and choline) and childhood asthma was explored using univariate and multivariate logistic regression analyses. The evaluation indexes were odds ratio (OR) and 95% confidence interval (CI). We further introduced the Bayesian kernel machine regression (BKMR) to assess the joint effect of the twelve vitamins on childhood asthma, the impact of an individual vitamin as part of a vitamin mixture, and the potential interactions among different vitamins. Results Among 4,715 eligible children and adolescents, 487 (10.3%) had asthma. After adjusting for covariates including race, family history of asthma, pregnant smoking, BMI Z-score, energy intake, breast feeding, and low birth weight, we found that for each 1-unit increase in vitamin K consumption, the odds of childhood asthma decreased 0.99 (P=0.028). The overall effect analysis reported a trend of negative relationship between the multivitamins and childhood asthma, especially at the 75th percentile and over. According to the BKMR models, when other vitamins are fixed at the median level, the odds of childhood asthma increased along with the elevated vitamin D (VD) and vitamin B2 (VB2), whereas along with the depressed vitamin C (VC). In addition, no potential interaction has been found between every two vitamins of multivitamins on childhood asthma. Conclusion Among children and adolescents who have high-risk of asthma, it may be beneficial to increase dietary consumption of multivitamins. Our findings recommended that children and adolescents should increase the intake of VC-rich foods, whereas control the dietary consumption of VD and VB2 in daily life.

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“…Low birth weight was defined as weight <2500 g [ 18 ]. The weight status of children and adolescents aged 2-17 years old was assessed by the BMI Z-score.…”

Section: Methodsmentioning

confidence: 99%

Multivitamin consumption and childhood asthma: a cross-sectional study of the NHANES database

Zhang,

Xu,

et al. 2024

BMC Pediatr

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“… 6 LBW is associated with the development of both hypertension and chronic kidney disease. 7 Additional risk factors such as rapid postnatal weight gain, sedentary lifestyle, stress, and effects of other systemic conditions, make this population exceptionally vulnerable to negative long term renal and cardiovascular outcomes.…”

Section: The Scope Of the Problemmentioning

confidence: 99%

Birth History and the Risk for Development of Hypertension in Adolescence

George,

Flynn

2024

Kidney International Reports

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Evaluation of eGFR methods in a sub-Saharan African community-based pediatric population

Alao,

Ibrahim,

Asinobi

et al. 2024

Pediatr Nephrol

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Accurate eGFR assessment is crucial for early CKD detection, management and optimal medication dosing, but its validation, especially for Cystatin C-based equations, are limited in African children and adolescents with CKD. This study evaluates eGFR equations utilising Cystatin C and creatinine in this population. Methods:This prospective community-based cohort study assessed CKD in children aged 1 to 18 using Cystatin C and serum creatinine. We evaluated eGFR performance with the Bland-Altman plot and ROC curve. Lin's concordance assessed agreement between various equations and the reference standard (Schwartz CKiD equations). Pairwise ROC curve comparisons determined statistical differences in estimation equation performance. Results:The mean age of 688 children and adolescents evaluated for CKD was 7.8 (± 3.9) years, with 341 (49.6%) being male. The Pottel equation had the lowest mean bias (-3.41, 95% CI: -2.57 to -4.25), highest discriminatory power (0.989), highest accuracy across all age groups, and highest CKD detection.Bouvet's formula had the highest mean bias ] across all age groups, but an average ROC discriminatory power of 0.889. Zappitelli had a lower ROC discriminatory value (0.547) but a modest bias ). Lin's concordance with Schwartz CKiD was highest with Pottel (0.99) and lowest with Bouvet (0.08). Zappetti and Chehade disagreed most, but Pottel and Chehade agreed closely on equation pairwise comparisons. Conclusion:In African children with CKD, Pottel's height-independent equation outperformed Chehade, Zappitelli, and Bouvet in terms of ROC discriminatory value, accuracy, and Schwartz CKiD concordance.Glomerular ltration rate (GFR) serves as a crucial indicator of renal function, and its estimation through the use of equations, such as the estimated GFR (eGFR), has become an essential tool in clinical practice.However, the applicability and accuracy of eGFR determination methods can vary signi cantly across diverse populations due to differences in age, ethnicity, and environmental factors. 4,5, 6,7 Sub-Saharan Africa, a region marked by its unique demographic and health landscape, presents distinct challenges and opportunities in pediatric nephrology. The pediatric population in this region faces a disproportionately higher burden of renal diseases, often in the context of prevalent infectious diseases, malnutrition, limited access to healthcare, inadequate renal supportive care resources, socioeconomic challenges, genetic predispositions and the scarcity of renal transplantation services. 8,9,10,11 . Delays in making diagnoses and a lack of awareness make it even more di cult to effectively manage CKD often at advance stages at presentation in this populatuon. 3 Yet, there is a paucity of data regarding the performance of cystatin C-based eGFR determination methods or in combination with creatinine, speci cally in sub-Saharan African children.The old Schwartz equation is widely used for estimating eGFR in older African children with normal kidney function, showing good agreement with measured...

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Reduced kidney function and hypertension in adolescents with low birth weight, NHANES 1999–2016

Cited by 6 publications

References 52 publications

Multivitamin consumption and childhood asthma: a cross-sectional study of the NHANES database

Multivitamin consumption and childhood asthma: a cross-sectional study of the NHANES database

Birth History and the Risk for Development of Hypertension in Adolescence

Evaluation of eGFR methods in a sub-Saharan African community-based pediatric population

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