Reduced membranous and ectopic cytoplasmic expression of DSC2 in esophageal squamous cell carcinoma: an independent prognostic factor

Fang, Wang‐Kai; Gu, Wei; Li, En‐Min; Wu, Zhi‐Yong; Shen, Zhong-Ying; Shen, Jian; Wu, Jian‐Yi; Pan, Feng; Lv, Zhuo; Xu, Xiu‐E; Huang, Qiao; Xu, Li‐Yan

doi:10.1016/j.humpath.2010.04.003

Cited by 32 publications

(35 citation statements)

References 28 publications

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“…Interestingly, our results are in accordance with a recently and independently published study in oesophageal squamous cell carcinoma 11. The authors showed that DSC2 expression was reduced significantly in squamous oesophageal cancer in both protein and messenger RNA levels, and that this reduction was significantly associated with poor survival and poor tumour differentiation.…”

Section: Discussionsupporting

confidence: 93%

Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma

et al. 2011

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Section: Discussionsupporting

confidence: 93%

Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma

et al. 2011

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“…6D). Reduced DSC2 expression is significantly correlated with higher tumor grading and is a prognostic biomarker for decreased survival in patients with multiple high-grade carcinomas [40-42]. In addition, we confirmed that GDNF promotes U251 glioma cell proliferation and significantly increases the proportion of cells in the S phase (Fig.…”

Section: Discussionsupporting

confidence: 69%

MiRNAs Mediate GDNF-Induced Proliferation and Migration of Glioma Cells

Zhang

Dong²,

Guo

et al. 2017

Cell Physiol Biochem

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Background/Aims: Glial cell line-derived neurotrophic factor (GDNF) is an important factor promoting invasive glioma growth. This study was performed to reveal a unique mechanism of glioma cell proliferation and migration. Methods: Human U251 glioma cells were used to screen the optimal GDNF concentration and treatment time to stimulate proliferation and migration. MicroRNA (MiRNA) expression profiles were detected by microarray and confirmed by real-time polymerase chain reaction (PCR). The target genes of differentially expressed miRNAs were predicted by miRWalk, and those targeted by multiple miRNAs were screened with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. A regulatory miRNA network was constructed using ingenuity pathway analysis (IPA). Target gene expression of differentially expressed miRNAs was examined by real-time PCR or mRNA microarray. Results: The results show that 50 ng/mL GDNF for 24 h significantly promotes U251 glioma cell proliferation and migration (P < 0.05). Seven miRNAs (hsa-miR-194-5p, hsa-miR-152-3p, hsa-miR-205-5p, hsa-miR-629-5p, hsa-miR-3609, hsa-miR-183-5p, and hsa-miR-487b-3p) were significantly up-regulated after GDNF treatment (P < 0.05). These miRNAs are primarily involved in signal transduction, cell adhesion and cell cycle through mitogen-activated protein kinase (MAPK) signaling, focal adhesion and glioma signal pathways. Five of these miRNAs (hsa-miR-194-5p, hsa-miR-152-3p, hsa-miR-205-5p, hsa-miR-183-5p, and hsa-miR-487b-3p) co-regulate TP53 and Akt. mRNA expression levels of four genes co-targeted by two or more up-regulated miRNAs were significantly decreased after GDNF treatment (P < 0.05). Conclusion: GDNF treatment of U251 glioma cells significantly increased the expression of seven miRNAs involved in cell adhesion and the cell cycle.

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“…Decreased DSG3 expression is associated with poor prognosis in lung cancer (Fukuoka et al, 2007). Recently, we report that desmocollin 2 expression level is an independent prognostic factor for ESCC (Fang et al, 2010). In this study, we find that negative expression of DSG3 is associated with an unfavorable prognosis in ESCC patients.…”

Section: Discussionsupporting

confidence: 59%

“…Recently, we have shown that desmocollin-2 (DSC2), the most widely distributed desmocollins family member, plays a causal role in esophageal cellular invasion and metastasis (Fang et al, 2013). DSC2 expression gradually decreases from regions of esophageal hyperplasia to dysplasia to carcinoma in situ, and may serve as a prognostic marker (Fang et al, 2010). However, no data are available in the literature concerning the expression of desmogleins in ESCC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

Fang

Gu²,

Liao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Reduced membranous and ectopic cytoplasmic expression of DSC2 in esophageal squamous cell carcinoma: an independent prognostic factor

Cited by 32 publications

References 28 publications

Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma

Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma

MiRNAs Mediate GDNF-Induced Proliferation and Migration of Glioma Cells

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

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