1992
DOI: 10.1002/jcp.1041520112
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Reduced mRNA levels for the multidrug‐resistance genes in cAMP‐dependent protein kinase mutant cell lines

Abstract: We have previously shown that in Chinese hamster ovary (CHO) cells, a mutant cell line with a defective regulatory subunit (RI) for the cAMP-dependent protein kinase (Abraham et al: Mol. Cell. Biol., 7:3098-3106, 1987), and a transfectant cell line expressing the same mutant kinase, showed increased sensitivity to a number of drugs that are known to be substrates for the multidrug transporter (P-glycoprotein). In the current study we have investigated the mechanism by which cAMP-dependent protein kinase contro… Show more

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Cited by 33 publications
(21 citation statements)
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“…Although this data concerns only one animal, this was never observed in ovaries before, as discussed in our previous study, where we stated that mdr1 and mdr3 expression were always concomitant (Schiengold et al, 2001). Noteworthy, considering the homologous genes to mouse mdr1 and mdr3 in humans, is that the activation of the MDR3 gene seems to be independent of the activation of the closely linked MDR1 gene (van der Bliek et al, 1988;Raymond et al, 1990;Chin et al, 1992).…”
Section: Discussionmentioning
confidence: 55%
“…Although this data concerns only one animal, this was never observed in ovaries before, as discussed in our previous study, where we stated that mdr1 and mdr3 expression were always concomitant (Schiengold et al, 2001). Noteworthy, considering the homologous genes to mouse mdr1 and mdr3 in humans, is that the activation of the MDR3 gene seems to be independent of the activation of the closely linked MDR1 gene (van der Bliek et al, 1988;Raymond et al, 1990;Chin et al, 1992).…”
Section: Discussionmentioning
confidence: 55%
“…Considerable evidence has accumulated to indicate that the expression of drug transporter genes can be transiently induced in response to chemotherapeutics (Kohno et al, 1989;Gekeler et al, 1998;Chin et al, 1990a;Asakuno et al, 1994;Hu et al, 1995;Ohga et al, 1996;Ichihashi and Kitajima, 2001;Brugger et al, 2002;Liu et al, 2002). This was first reported in CCRF-CEM/ ActD cells that exhibited an increased steady-state level of MDR1 RNA following short-term exposure to actinomycin D (Gekeler et al, 1998); this increase was mediated, at least in part, at the level of transcription.…”
Section: Chemotherapeuticsmentioning
confidence: 99%
“…strongly augmented in normal kidney cell lines after acute exposure to cytotoxic drugs [13]. Several studies are in favor of a link with steroids.…”
Section: Abbreviutrons Dex Dexamethasone;mentioning
confidence: 99%