Reduced nerve growth factor levels in stress-related brain regions of folate-deficient mice

Eckart, Sarah; Hörtnagl, Helmut; Kronenberg, Golo; Gertz, Karen; Hörster, Henrik; Endres, Matthias; Hellweg, Rainer

doi:10.1016/j.neuroscience.2013.04.014

Cited by 12 publications

(7 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Knock-out models in mice have indicated impaired uracil repair and impaired DNA glycosylase activity, secondary to vitamin B 9 depletion that resulted in moderate deficiency in this vitamin. Overall in this situation, there is promotion of neurodegenerative processes resulting in neuronal death and an inhibition of neurogenesis, associated with a region-specific reduction in brain-derived neurotrophic factor and glutathione ( 213 ) , and nerve growth factor ( 214 ) . Duthie ( 212 ) has further highlighted the relative contribution of vitamin B 9 deficiency, having observed that (moderate) FD, and not an inadequate status of other methyl-donors with overlapping functions (for example, choline and methionine), leads to progressive strand-breaking, DNA damage in lymphocytes (100 % after 8 weeks).…”

Section: Folate (Vitamin B9)mentioning

confidence: 99%

Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations

2018

View full text Add to dashboard Cite

The possible roles of selected B vitamins in the development and progression of sarcopenia are reviewed. Age-related declines in muscle mass and function are associated with huge and increasing costs to healthcare providers. Falls and loss of mobility and independence due to declining muscle mass/function are associated with poor clinical outcomes and their prevention and management are attractive research targets. Nutritional status appears a key modifiable and affordable intervention. There is emerging evidence of sarcopenia being the result not only of diminished anabolic activity but also of declining neurological integrity in older age, which is emerging as an important aspect of the development of age-related decline in muscle mass/function. In this connection, several B vitamins can be viewed as not only cofactors in muscle synthetic processes, but also as neurotrophic agents with involvements in both bioenergetic and trophic pathways. The B vitamins thus selected are examined with respect to their relevance to multiple aspects of neuromuscular function and evidence is considered that requirements, intakes or absorption may be altered in the elderly. In addition, the evidence base for recommended intakes (UK recommended daily allowance) is examined with particular reference to original datasets and their relevance to older individuals. It is possible that inconsistencies in the literature with respect to the nutritional management of sarcopenia may, in part at least, be the result of compromised micronutrient status in some study participants. It is suggested that in order, for example, for intervention with amino acids to be successful, underlying micronutrient deficiencies must first be addressed/eliminated.

show abstract

Section: Folate (Vitamin B9)mentioning

confidence: 99%

Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations

2018

View full text Add to dashboard Cite

show abstract

“…A variety of behavioural tests are widely used to assess higher-order brain functions. Behaviour is strongly affected by the experimental conditions used 1 – 4 , so it is crucial that, as far as possible, experiments are performed using mice with the same genetic background and sex, and under identical environmental conditions. Males are preferred over females for use in behavioural studies because males do not experience dynamic hormonal changes associated with the oestrous cycle 5 .…”

Section: Introductionmentioning

confidence: 99%

Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice

Horii

Nagasawa

Sakakibara

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Group-housed male mice exhibit aggressive behaviour towards their cage mates and form a social hierarchy. Here, we describe how social hierarchy in standard group-housed conditions affects behaviour and gene expression in male mice. Four male C57BL/6 mice were kept in each cage used in the study, and the social hierarchy was determined from observation of video recordings of aggressive behaviour. After formation of a social hierarchy, the behaviour and hippocampal gene expression were analysed in the mice. Higher anxiety- and depression-like behaviours and elevated gene expression of hypothalamic corticotropin-releasing hormone and hippocampal serotonin receptor subtypes were observed in subordinate mice compared with those of dominant mice. These differences were alleviated by orally administering fluoxetine, which is an antidepressant of the selective serotonin reuptake inhibitor class. We concluded that hierarchy in the home cage affects behaviour and gene expression in male mice, resulting in anxiety- and depression-like behaviours being regulated differently in dominant and subordinate mice.

show abstract

“…Interestingly, even though most studies use identical strains of inbred mice, variability in experimental outcomes is often a problem [7, 38]. It is well known, although perhaps underappreciated, that many mundane aspects of the lab environment such as diet [9], cage bedding [37], or noise levels [28] can have a major impact on study outcomes. The sex of the animal is also critical, and most neuroscience studies focus exclusively on male rodents [2].…”

Section: Introductionmentioning

confidence: 99%

Fighting in the home cage: Agonistic encounters and effects on neurobiological markers within the social decision-making network of house mice (Mus musculus)

Greenberg

Howerton

Trainor

2014

Neuroscience Letters

View full text Add to dashboard Cite

Inbred strains of mice, such as C57Bl/6, have become preferred animal models for neurobehavioral studies. A main goal in creating inbred lines is to reduce the effects of individual genetic variation on observed phenotypes. Most studies use only males, and there is increasing evidence that agonistic interactions within the home cage may produce systematic variability in behavior and brain function. Previous studies have demonstrated that the outcomes of aggressive interactions have powerful effects on the brain and behavior, but less is known about whether aggressive interactions within the home cage have similar effects. We assessed group-housed laboratory mice C57Bl/6 for competitive ability and then tested the extent high competitive ability (CA) or low CA was related to gene and protein expression within related pathways. We focused on a broad social behavior network, including the nucleus accumbens (NAc) and bed nucleus of the stria terminalis (BNST). High CA mice had significantly more corticotropin releasing hormone receptor 2 (CRHR2) and estrogen receptor alpha (ESR1) mRNA in the BNST. Our data suggest a simple test of CA could yield valuable information that could be used to reduce error variance and increase power in neurobiological studies using mice.

show abstract

Reduced nerve growth factor levels in stress-related brain regions of folate-deficient mice

Cited by 12 publications

References 54 publications

Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations

Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations

Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice

Fighting in the home cage: Agonistic encounters and effects on neurobiological markers within the social decision-making network of house mice (Mus musculus)

Contact Info

Product

Resources

About