Reduced Regional Gray Matter Volume in Patients with Chronic Obstructive Pulmonary Disease: A Voxel-Based Morphometry Study

Zhang, H.; Wang, X.; Lin, Jianzhong; Sun, Yanqin; Huang, Yue; Yang, Tianhe; Zheng, Shi-Li; Fan, Ming; Zhang, J.

doi:10.3174/ajnr.a3235

Cited by 60 publications

(71 citation statements)

References 38 publications

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“…SFG=superior frontal gyrus, dmPFC=dorsomedial prefrontal cortex, Pre-SMA=pre-supplement motor area neuroimaging study also did not find any local WM volume reduction in the patients with COPD (Ryu et al 2013). Our findings are, at least partly, consistent with previous VBM studies, which reported gray matter volume reductions in prefrontal, temporal and motor cortices (Zhang et al 2012(Zhang et al , 2013. The present findings suggest most of the decreased gray matter volumes observed in VBM studies are likely to represent cortical thinning, although there may also be a component of cortical area reduction.…”

Section: Discussionsupporting

confidence: 94%

“…Surface-based measures of CTh, SA and LGI provide more precise neurobiological representations, and has been shown to be more sensitive in capturing subtle, previously undetected anatomical alterations (Jiao et al 2010;Pereira et al 2012;Kelly et al 2013), particularly in deep sulcal regions (Lerch and Evans 2005). In the present study, novel regions were discovered primary in highly convoluted parietal cortex besides those detected by traditional volumetric methods in previous studies (Zhang et al 2012(Zhang et al , 2013. Damage in DLPFC has been recurred and identified as an important area in this study which contributes notably to the visuospatial deficits.…”

Section: Discussionmentioning

confidence: 45%

“…Volumetric approaches like tensor-and voxel-based morphometry (VBM) based on structural magnetic resonance imaging (MRI) have been used to measure brain damage in COPD patients (Dodd et al 2012;Zhang et al 2012Zhang et al , 2013. However, VBM is a composite measure of a combination of changes in cortical thickness (CTh), surface area (SA), and folding, and so specific neuropathological interpretations are thus impossible.…”

Section: Introductionmentioning

confidence: 99%

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Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study

Chen

Lin

Zhang

et al. 2015

Brain Imaging and Behavior

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Neural impairments accompanying chronic obstructive pulmonary disease (COPD) have received growing research attention. Previous neuroimaging studies exclusively used volumetric methods to measure cortical volume as a whole rather than focusing on anatomical and neuropathological distinct indices. Here we decomposed the cortical architecture into cortical thickness (CTh), surface area (SA), and gyrification, for the first time, to provide a more integrative profile of brain damage in COPD. Clinical T1-weighted MRI scans were acquired in 25 stable COPD patients (mean age 69) and 25 age-matched controls. Images were processed using surface-based morphometry to obtain cortical parameters enabling more accurate measurement in deep sulci and localized regional mapping. Demographic, physiological, and cognitive assessments were made and correlated with cortical indices. Compared to controls, COPD patients showed significantly reduced CTh broadly distributed in motor, parietal, and prefrontal cortices, together with more circumscribed SA reduction in dorsomedial prefrontal cortex and Broca's area (cluster-level P < 0.05 corrected). No abnormal gyrification was detected. Decreased CTh in parietofrontal networks strongly correlated with visuospatial construction impairment in COPD patients. Furthermore, thinner dorsolateral prefrontal cortex (DLPFC) best predicted poorer performance (r (2) = 0.315, P = 0.004), and was associated with lower arterial oxygen saturation. These data indicate that cortical thinning is a key morphologic feature associated with COPD that could be partly attributed to oxygen desaturation and contributes to COPD visual memory and drawing deficits. Surface-based morphometry provides valuable information concerning COPD, and could ultimately help us to characterize the neurodegenerative pattern and to clarify neurologic mechanisms underlying cognitive dysfunction in COPD patients.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study

Chen

Lin

Zhang

et al. 2015

Brain Imaging and Behavior

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“…Neuroimaging studies showed there are signiicantly lowered gray mater volumes in several brain regions as hippocamp [7], limbic and paralimbic structures [77], precuneus, bilateral calcarine, right superior temporal gyrus/middle temporal gyrus, bilateral fusiform, right inferior parietal lobule [78], cingulate and amygdala [8], dorsolateral prefrontal cortex [77] etc., evidenced by diferent neuroimaging techniques based on magnetic resonance imaging (MRI). Performance accuracy has increased by introducing voxel-based morphometry analysis also based on MRI.…”

Section: Clinical Consequences Of An Afected Cognition; Measure Methodsmentioning

confidence: 99%

Neurocognitive Impairment as Systemic Effects of COPD

Oancea¹,

Tudorache²,

Tudorache³

2018

COPD - An Update in Pathogenesis and Clinical Management

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Mild cognitive impairment (MCI), also known as incipient dementia, is characterized by the decline of cognitive function greater than expected for a certain age and educational level of the individual but not severe enough to interfere with their daily activities. However, this mild cognitive impairment afects several areas: visuospatial, memory, atention and luency and it is a signiicant concern because it decreases the quality of life and treatment adherence of these patients. On the other hand, evidence suggests that individuals with Chronic obstructive pulmonary disease (COPD) also present an important risk of falls: 46% of these patients experience a fall/year, sometimes with fatal consequences. Standard clinical balance measures can predict the risk of falls in this population. Moreover, increased inlammatory biomarkers are associated with the decrease of cognitive functions and a higher risk of falls in this population. Patients with COPD have a higher balance and cognitive impairment than their healthy peers Therefore, it is important to identify, assess and understand the relevance of these comorbidities in order to characterize the full clinical spectrum of COPD and adjust prevention strategies, given the devastating consequences of these problems.

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“…The newborns with congenital heart disease (45,46). For other diseases, changes have been found in adult brain for type 2 diabetes (47-50), asthma (51,52), and chronic obstructive pulmonary disease (53)(54)(55). Improvements in diagnostic methods will make it possible to establish changes during early life.…”

Section: The Role Of Hypoxia In the Neurogenesis Stimulationmentioning

confidence: 99%

Trends in the use of preconditioning to hypoxia for early prevention of future life diseases

Basovich¹

2013

Biosci Trends

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Reduced Regional Gray Matter Volume in Patients with Chronic Obstructive Pulmonary Disease: A Voxel-Based Morphometry Study

Abstract: BACKGROUND AND PURPOSE:Decreased oxygen supply may cause neuronal damage in the brains of patients with COPD, which is manifested by clinical symptoms such as neuropsychological deficits and mood disorders. The aim of the present study was to investigate brain gray matter change in COPD.

Cited by 60 publications

References 38 publications

Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study

Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study

Neurocognitive Impairment as Systemic Effects of COPD

Trends in the use of preconditioning to hypoxia for early prevention of future life diseases

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