Reduced Serum Phosphorus Levels Were Associated with Metabolic Syndrome in Men But Not in Women: A Cross-Sectional Study among the Japanese Population

Abstract

unexpectedly positively correlated with SP levels in women. Reduced SP levels were associated with MetS in men but not in women.

Association of Serum Calcium and Phosphate Concentrations with Glucose Metabolism Markers: The Furukawa Nutrition and Health Study

“…To date, no study has been conducted to assess the association between serum phosphate concentration and HOMA-IR. The observed inverse association of serum phosphate concentration with FPG is in agreement with the findings of previous studies [ 14 , 15 , 16 ]. In a large Japanese study conducted among 16,041 individuals undergoing routine health checkups at the Iida Municipal Hospital [ 15 ], serum phosphate concentration was significantly and inversely associated with FPG.…”

“…To date, few studies have investigated the association of serum calcium [ 7 , 11 , 12 , 13 , 14 ] and phosphate [ 7 , 14 , 15 , 16 ] concentrations with glucose metabolism markers, such as IR, fasting plasma glucose (FPG), or glycated hemoglobin (HbA1c). Among them, some [ 11 , 12 , 13 , 14 ], although not all [ 7 ], studies have reported that elevated calcium concentration is associated with increased FPG [ 11 , 12 , 14 ], IR [ 11 , 12 , 13 ], and HbA1c [ 11 ].…”

“…Among them, some [ 11 , 12 , 13 , 14 ], although not all [ 7 ], studies have reported that elevated calcium concentration is associated with increased FPG [ 11 , 12 , 14 ], IR [ 11 , 12 , 13 ], and HbA1c [ 11 ]. In contrast, a low phosphate concentration has been found to be associated with increased FPG [ 14 , 15 ] and insulin sensitivity [ 16 ]. In contrast, the calcium–phosphate product concentration was not found to be correlated with plasma glucose, insulin sensitivity, or insulin secretion [ 7 ].…”

“…However, limited evidence is available on these issues among Asian individuals, who have a lower body mass index (BMI) [ 17 ] and insulin secretion capacity [ 18 ] than Westerners. To the best of our knowledge, the association of serum calcium [ 13 ] and phosphate [ 15 ] concentrations with FPG and homeostatic model assessment of insulin resistance (HOMA-IR) has been investigated in only one Asian study previously. There has been no study of the association of serum phosphate with HbA1c levels which reflects a long-term glucose status.…”

Effect of Age and Gender on Some Biochemical, Hormones and Adipocytokines Parameters in Iraqi Type 2 Diabetes Mellitus Patients

“…In some studies that PTH level was higher in T2DM patients than the control but it was not significantly. PTH could increase intracellular calcium in skeletal muscle and adipocytes, which would consequently suppress glucose uptake by those tissues and induce IR 42 . Differences in the prevalence of vitamin D deficiency in males and females may contribute to the different degrees of association between PTH and vitamin D 44 .…”