Reduced survival in patients with early-stage non-small-cell lung cancer is associated with high pleural endothelial progenitor cell levels

Pirro, Matteo; Cagini, Lucio; Mannarino, Massimo Raffaele; Andolfi, Marco; Potenza, Rossella; Paciullo, Francesco; Bianconi, Vanessa; Frangione, Maria Rosaria; Bagaglia, Francesco; Puma, Francesco

doi:10.1093/ejcts/ezw197

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…Blood and lymphatic human EPC derive from CD34 + hematopoietic progenitors 29,30 and share endothelial specific markers with mature ECs, such as TIE-1, TIE-2, VEGFR-2, VEGFR-3 or vascular endothelial (VE)-cadherin 31 . In several human cancers, EPC have been detected at higher frequency in the peripheral blood of patients relative to healthy individuals 30,32,33 and associated with poor patient survival, cancer dissemination and progression 34 . Further, EPC are home to sites of neovascularization and have been found inserted, in very low numbers, into the tumor endothelium in several human cancers 35-37 .…”

Section: Introductionmentioning

confidence: 99%

TIE-2 expressing monocytes in human cancers

et al. 2017

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Tumor-associated macrophages (TAM) are well known as a key player in the tumor microenvironment, which support cancer progression. More recently, a lineage of monocytes characterized by the expression of the TIE-2/Tek angiopoietin receptor identified a subset of circulating and tumor-associated monocytes endowed with proangiogenic activity. TIE-2 expressing monocytes (TEM) were found both in humans and mice. Here, we review the phenotypes and functions of TEM reported so far in human cancer and their potential use as markers of cancer progression and metastasis. Finally, we discuss the therapeutic approaches currently used or proposed to target TEM.

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Section: Introductionmentioning

confidence: 99%

TIE-2 expressing monocytes in human cancers

et al. 2017

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Enzymes involved in tumor-driven angiogenesis: A valuable target for anticancer therapy

Ricciuti¹,

Foglietta²,

Bianconi

et al. 2019

Seminars in Cancer Biology

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Immune modulation by curcumin: The role of interleukin-10

Mollazadeh

Cicero

Blesso

et al. 2017

Critical Reviews in Food Science and Nutrition

308

141

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Cytokines are small secreted proteins released by different types of cells with specific effects on cellular signaling and communication via binding to their receptors on the cell surface. IL-10 is known to be a pleiotropic and potent anti-inflammatory and immunosuppressive cytokine that is produced by both innate and adaptive immunity cells including dendritic cells, macrophages, mast cells, natural killer cells, eosinophils, neutrophils, B cells, CD8 T cells, and T1, T2, and T17 and regulatory T cells. Both direct and indirect activation of the stress axis promotes IL-10 secretion. IL-10 deregulation plays a role in the development of a large number of inflammatory diseases such as neuropathic pain, Parkinson's disease, Alzheimer's disease, osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, inflammatory bowel disease, and allergy. Curcumin is a natural anti-inflammatory compound able to induce the expression and production of IL-10 and enhancing its action on a large number of tissues. In vitro and in pre-clinical models curcumin is able to modulate the disease pathophysiology of conditions such as pain and neurodegenerative diseases, bowel inflammation, and allergy, but also of infections and cancer through its effect on IL-10 secretion. In humans, at least one part of the positive effects of curcumin on health could be related to its ability to enhance IL-10 -mediated effects.

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Reduced survival in patients with early-stage non-small-cell lung cancer is associated with high pleural endothelial progenitor cell levels

Cited by 3 publications

References 20 publications

TIE-2 expressing monocytes in human cancers

TIE-2 expressing monocytes in human cancers

Enzymes involved in tumor-driven angiogenesis: A valuable target for anticancer therapy

Immune modulation by curcumin: The role of interleukin-10

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