2022
DOI: 10.1111/jpc.16128
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Reducing antibiotic use in asymptomatic term infants exposed to maternal chorioamnionitis: Predictive role of sepsis risk calculator

Abstract: Aim The sepsis risk calculator (SRC) has been shown to reduce empirical antibiotic usage in neonates at risk of early‐onset sepsis without increasing adverse clinical outcomes. However, its use for categorising and improving identification of at‐risk neonates exposed to chorioamnionitis in the local population has not been reported. This study compares the management guided by the SRC to our unit's clinical practice of administering empirical antibiotics to all term neonates (born ≥37 weeks gestation), symptom… Show more

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“…22,28 Increasing inconsistencies in chorioamnionitis diagnosis have recently been reported and the broadening of its definition has led studies to reevaluate whether chorioamnionitis alone should indicate empiric treatment of asymptomatic newborns. [29][30][31][32][33][34] In 2016 in California, Braun et al 32 found that in 1243 recorded chorioamnionitis, 5 (0.4%) resulted in the newborn developing EONS. Chorioamnionitis is undeniably a risk factor for developing EONS, however, perhaps not a major one as previously thought.…”
Section: Discussionmentioning
confidence: 99%
“…22,28 Increasing inconsistencies in chorioamnionitis diagnosis have recently been reported and the broadening of its definition has led studies to reevaluate whether chorioamnionitis alone should indicate empiric treatment of asymptomatic newborns. [29][30][31][32][33][34] In 2016 in California, Braun et al 32 found that in 1243 recorded chorioamnionitis, 5 (0.4%) resulted in the newborn developing EONS. Chorioamnionitis is undeniably a risk factor for developing EONS, however, perhaps not a major one as previously thought.…”
Section: Discussionmentioning
confidence: 99%