Reducing antibiotic use: Selective metaphylaxis with florfenicol in commercial feedlots

Gonzalez-Martin, Juan-Vicente; Elvira, Laura Ruiz de; López, M. Cerviño; Pérez‐Villalobos, Natividad; López-Guerrero, Enrique Calvo; Astiz, Susana

doi:10.1016/j.livsci.2011.05.016

Cited by 21 publications

(19 citation statements)

References 13 publications

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“…In addition, there is abundant evidence that metaphylaxis has significant benefits in reducing the impact of bovine (269,270) respiratory disease (4,180,258), lameness in ewes (229), and diarrhoea in pre-weaned calves (143). As diagnostic capacity improves, selective metaphylaxis is likely to become more common (88), with reduced use of antimicrobial agents consistent with high animal health. There is growing evidence that another benefit of metaphylactic use of antimicrobial agents may be a reduced propensity to select for resistant bacteria.…”

Section: Therapeutic Use Of Antimicrobial Agentsmentioning

confidence: 99%

Use of antimicrobial agents in livestock

Page¹,

Gautier²

2012

Rev. Sci. Tech. OIE

197

181

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Antimicrobial agents, especially antibacterial agents, are used throughout the world, across a diverse array of extensive and intensive livestock production systems, to protect the health and welfare of livestock and to improve their performance. While some agents that are used in livestock belong to classes that have no counterpart in human medicine, this is not the case for the most widely used agents: the tetracyclines, penicillins, macrolides and sulphonamides. Many bacterial diseases of livestock cause devastating losses of animal life and productivity. As a result, their keepers can lose their livelihoods and see a dramatic reduction in income, so there is often a great sense of urgency to treat affected animals early. However, there are a large number of bacterial pathogens that cause disease and it is frequently difficult to reach a conclusive diagnosis prior to instituting treatment. There are many ways in which existing uses of antimicrobial agents can be improved, amongst the most important are increased utilisation of veterinary professional services, the introduction of enhanced infection control measures, improved point-of-care diagnostic tests, and the application of physiologically based population pharmacokinetic-pharmacodynamic modelling.

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Section: Therapeutic Use Of Antimicrobial Agentsmentioning

confidence: 99%

Use of antimicrobial agents in livestock

Page¹,

Gautier²

2012

Rev. Sci. Tech. OIE

197

181

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“…Thus, the early use of efficacious antimicrobials is important to stop progression of infection and the spread of the disease in the herd. Among the various antimicrobials available, florfenicol (Nuflor, MSD Animal Health) is a broad-spectrum antibiotic, and its injectable formulation is designed to provide prolonged levels of the antibiotic following either a single subcutaneous injection or two intramuscular injections administered 48 hours apart (Varma and others 1986, Adams and others 1987, de Haas and others 1994, Lobell and others 1994, Varma 1994, Varma and others 1998, de Haas and others 2002, Catry and others 2008, Gonzalez-Martin and others 2011, Thiry and others 2011). …”

Section: Introductionmentioning

confidence: 99%

Treatment of naturally occurring bovine respiratory disease in juvenile calves with a single administration of a florfenicol plus flunixin meglumine formulation

Thiry

Gonzalez-Martin²,

Elvira³

et al. 2014

Veterinary Record

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The efficacy and safety of a florfenicol plus flunixin meglumine formulation in the treatment of respiratory disease was evaluated in calves less than six weeks of age, compared with a positive control group treated with a well-established florfenicol formulation. A total of 210 calves, selected from nine sites in Belgium, France and Spain, showing severe signs of respiratory disease, were randomly assigned to treatment with either florfenicol plus flunixin meglumine (Resflor; MSD Animal Health) or florfenicol (Nuflor; MSD Animal Health), both administered subcutaneously once. Animals were clinically observed daily for 10 days following treatment initiation. The predominant respiratory pathogens were Pasteurella multocida, Mycoplasma bovis, Mannheimia haemolytica and Histophilus somni. All isolates were subject to in vitro sensitivity testing and found susceptible to florfenicol. In both groups, rectal temperature dropped and clinical index (depression and respiratory signs) significantly improved after treatment. Specifically, for the change in rectal temperature from pretreatment to six hours post-treatment, the florfenicol-flunixin formulation was found significantly superior to florfenicol. Moreover, the florfenicol-flunixin formulation alleviated the clinical signs of disease more rapidly, and was demonstrated to be non-inferior to florfenicol on days 4 and 10. The use of the product combining florfenicol and flunixin in calves is safe and efficacious in the treatment of outbreaks of bovine respiratory disease.

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“…Since beef cattle change ownership more than once during their life cycles, feedlot owners could not easily followed the good veterinary practices. So, the common approach based on the assumption that animals in the group are either susceptible or already carrying diseases [14]. This assumption is applied in USA, when 83% of feedlot cattle received antibiotics through feed or water [15].…”

Section: Mass Production Of Beefmentioning

confidence: 99%

“…Livestock producers should keep files and records to register causes and nature of infections and the available antibiotic products to facilitate the right and correct decision [14].…”

Section: Cautions and Precautions Before Prescribing Veterinary Antibmentioning

confidence: 99%

Necessary Usage of Antibiotics in Animals

Saad¹,

Ahmed²

2018

Antibiotic Use in Animals

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Animals could become sick at any time of their lives, just like all people exposed. Many of the antibiotics administered to animals are identical to or closely drugs used in human. All animal species in general and food-producing animals, in particular, are commonly exposed to antibiotics to treat and prevent infectious diseases or to promote growth. Antibiotics would not be necessary if animals were raised differently under good veterinary and husbandry practices that were less crowded and more sanitary. The proper and responsible use of antibiotics in veterinary medicine mandate an active cooperation between all the interested parties involved in livestock production cycles. All parties are invited to act together to ensure the ultimate goals of maintaining the efficacy and safety of veterinary antibiotics and complying the established maximum residue limits (MRLs) of the products of animal origin intended for human consumption. Antibiotics as hazardous substances should be applied and directed during the different steps starting from prescription until ensuring the withdrawal period under the supervision of professionals and veterinarians. Practices indicated that there is a need to improve sensitivity testing services and facilities before prescribing the proper antibiotic.

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Reducing antibiotic use: Selective metaphylaxis with florfenicol in commercial feedlots

Cited by 21 publications

References 13 publications

Use of antimicrobial agents in livestock

Use of antimicrobial agents in livestock

Treatment of naturally occurring bovine respiratory disease in juvenile calves with a single administration of a florfenicol plus flunixin meglumine formulation

Necessary Usage of Antibiotics in Animals

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