Reducing severe spasticity in cerebral palsy following meningoencephalitis by botulinum toxin

Gunawan, Prastiya Indra; Saharso, Darto

doi:10.13181/mji.v26i1.1297

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Similarly, HIE produces 2-9 per 1000 babies born in developed and developing countries (3) . Most affected children are physical and / or neurological disabilities in a sustainable life (4,5) .…”

Section: Introductionmentioning

confidence: 99%

TNF-α and IL-10 levels in hipoxic ischemic rat brain receiving stem cell

Gunawan

Noviandi

Purwati

2022

ijhs

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To investigate the effect of intracerebral adipose neural stem cell transplantation in the inflammatory process after brain HI. The study used 16male Wistar rats aged 2 months which were randomly divided into the following group: Ischemia-Reperfusion group (IR, n=8) and ANSC-treated group (IR+ANSC, n=8). IR was performed by right common carotid artery occlusion for 2 hours, hypoxia procedure for 1 hour and reperfusion. ANSC was prepared from rats adipose tissue and processed in Laboratory. ANSC was inserted intracerebally after hypoxia procedure and after 48 hours the blood sample were analyzed by using ELISA. T-test for independent samples was used for statistial analysis. There were no significant differences in the TNF-α level between the IR group and IR+ANSC group. There were statistically significant difference in IL-10 level between groups (P< 0.05). Intracerebral ANSC transplantation cannot reduce TNF-α expression and increase IL-10 expression in brain ischemia induced by CCA ligation and hypoxia.

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Section: Introductionmentioning

confidence: 99%

TNF-α and IL-10 levels in hipoxic ischemic rat brain receiving stem cell

Gunawan

Noviandi

Purwati

2022

ijhs

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“…Activation of motor muscular becomes inefficient and uncoordinated due to neuromuscular and musculoskeletal disorders. Neuromuscular and musculoskeletal dysfunctions affect biomechanical difficulties that make the complexity of the problem 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Effective interventions in mild CP is essential for maintaining or improving motor skill 4 . It is encourage to know whether the limitations can be minimized even though the underlying disorder can not be cured 3 . Ground gait training physical therapy in CP children result no better accomplishment of motion skills, functional balance and mediolateral oscillation than treadmill exercises 5 .…”

Section: Introductionmentioning

confidence: 99%

Combination of standard physical therapy with partial body weight supported treadmill training in children with spastic diplegic cerebral palsy

Gunawan¹,

Lusiana²,

Noviandi³

et al. 2022

ijhs

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Standard physical therapy (SPT) with ground gait training is well recognized to improve the motor skill in cerebral palsy (CP) disease. Confirmation is required on achieving better gross motor function with partial body weight supported treadmill training (PBWSTT). The objective of the study is to analyze combination of SPT with PBWSTT for gross motor function children with spastic diplegic CP who able to walk. A prospective design was conducted in CP patients 2-7 years of age with Gross Motor Function Classification System (GMFCS) I-III and received physical therapy 2 times per week, 20 minutes per session, a total of 20 sessions. The treatment group is continued by PBWSTT for 20 minutes per session. Gross Motor Function Measure (GMFM)-66 of walking, running, and jumping (dimension E) is measured in pre and post-physical therapy. Data were analyzed descriptively. There were 10 subjects and divided into 5 subjects in the control and the rest in the treatment group. The mean age was 48.4 months and 63.4 months respectively. The Average score of GMFM-66 dimension E pre and post-SPT were 63.54 and 65.24, the difference is 1.7 (2.67%) from the initial score.

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“…is unclear due to the absence of a national registry. However, available data from Surabaya, Indonesia indicated 48 CP cases over a 2-year research period [5][6][7]. CP can potentially lead to socioeconomic issues as well as mental health problems for affected children and their families.…”

mentioning

confidence: 99%

Brain Magnetic Resonance Imaging in Indonesian Patients with Cerebral Palsy

Gunawan,

Noviandi,

Samosir

2023

Ann Child Neurol

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Purpose: Cerebral palsy (CP) is a neurological health problem that affects children around the world and warrants particular attention. Magnetic resonance imaging (MRI) can be used to visualize brain disorders, as it provides a clear view of the brain’s anatomy, including the location of any damage or structural abnormalities. The objective of this study was to obtain a detailed MRI representation of patients with CP. Methods: This study employed a retrospective design involving the examination of medical records. It included CP patients aged between 1 and 16 years who had undergone brain MRI examinations. The Gross Motor Function Classification System scale was used to classify limitations in functional motor ability among these patients. The brain MRI results were categorized as either normal or abnormal. Results: Of 60 CP cases, 50% were classified as severe, with the remaining cases considered mild to moderate. Epilepsy was present in 66.7% of patients with severe CP. The most common type of CP, among both mild-to-moderate and severe cases, was quadriplegia. Gray matter lesions on brain MRI were more common in severe than mild-to-moderate cases, while vascular insult lesions and brain malformations were less frequent. A significant difference was observed in the severity of CP when a gray matter lesion was present on MRI. Conclusion: Most children with CP exhibited abnormal results on brain MRI. Lesions of the white and gray matter were the most frequently observed. MRI plays a crucial role in understanding the underlying pathological brain abnormalities in CP.

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Reducing severe spasticity in cerebral palsy following meningoencephalitis by botulinum toxin

Cited by 3 publications

References 11 publications

TNF-α and IL-10 levels in hipoxic ischemic rat brain receiving stem cell

TNF-α and IL-10 levels in hipoxic ischemic rat brain receiving stem cell

Combination of standard physical therapy with partial body weight supported treadmill training in children with spastic diplegic cerebral palsy

Brain Magnetic Resonance Imaging in Indonesian Patients with Cerebral Palsy

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