Reduction- and pH-Sensitive lipoic acid-modified Poly(l-lysine) and polypeptide/silica hybrid hydrogels/nanogels

Zhang, Yi Xuan; Chen, Yu Fon; Shen, Xuan; Hu, Jin-Jia

doi:10.1016/j.polymer.2016.01.030

Cited by 58 publications

(22 citation statements)

References 56 publications

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“…Injectable hydrogels are attractive vehicles for sustainably delivering payloads to ap articular area inside the body, [114] and dynamic hydrogels have shown promising characteristics for implantation. [115][116][117][118][119] As an example, GC/OHCÀPEOÀPPOÀPEOÀ CHO can carry both hydrophilic and hydrophobic drugs and be administrated by injection.H ydrophobicp aclitaxel and hydrophilic DOX are entrapped in the PPO domain and the aqueous phase, respectively.Al iquid formulation was prepared at pH 5.0 and injected into the tumor site on am ice model, which immediatelyg elled,o wing to an increase in the surrounding pH value. Thea dministration method achieved low drug concentration in the blood and, hence,l ess-serious cardiotoxicity,w hich contributed ap rolonged lifetime, together with the antitumore ffect of the drugs on the animals.…”

Section: Applications In Drug Delivery and Tissue Engineeringmentioning

confidence: 99%

Benzoic‐Imine‐Based Physiological‐pH‐Responsive Materials for Biomedical Applications

Yang

2016

Chemistry An Asian Journal

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The benzoic imine is a dynamic covalent bond, which is stable around neutral pH value (ca. 7.4), but starts to hydrolyze at the extracellular pH value of solid tumors (ca. 6.5) and rapidly disintegrates at endosome and lysosome pH values (ca. 4.5-6.5). This characteristic is promising for the construction of physiological-pH-responsive materials, such as polymeric micelles, nanoparticles, and hydrogels for pharmaceutical and tissue-engineering applications. This Focus Review summarizes recent progress in the design and synthesis of pH-sensitive materials that contain the benzoic imine bond with biomedical objectives.

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Section: Applications In Drug Delivery and Tissue Engineeringmentioning

confidence: 99%

Benzoic‐Imine‐Based Physiological‐pH‐Responsive Materials for Biomedical Applications

Yang

2016

Chemistry An Asian Journal

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“…Zhang et al . have obtained a reduction and pH dual stimuli‐sensitive hydrogel by amidation of poly( l‐ lysine) with lipoic acid using EDC and NHS as activator . However, previous work mainly focused on the coupling with side carboxyl or amine groups that were located on poly( l‐ glutamate) or poly( l‐ lysine).…”

Section: Introductionmentioning

confidence: 99%

Dual stimuli‐responsive polypeptide prepared by thiol‐ene click reaction of poly(l‐cysteine) and N, N‐dimethylaminoethyl acrylate

et al. 2019

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Stimuli‐responsive polymers that can undergo conformational changes with external triggers have enabled themselves as smart materials for various utilizations, among which biodegradability is of particular importance to be engineered for biomedical application. In this study, a thermo and pH dual responsive polypeptide (N, N‐dimethylaminoethyl acrylate‐modified poly(l‐cysteine)) (PLC‐g‐DMAEA) was prepared by the combination of N‐carboxyanhydride ring‐open polymerization and thiol‐ene click chemistry. The biodegradable poly(l‐cysteine) (PLC) with pendant thiol groups provided an easily clickable backbone for postmodification, which was demonstrated by reacting with a well‐known monomer of N, N‐dimethylaminoethyl acrylate (DMAEA) to achieve both temperature and pH responsiveness. The irreversible thermo‐response of PLC‐g‐DMAEA could be attributed to the ordered β‐sheets formed upon heating, leading to the trapped side groups with poor water accessibility. Moreover, this copolymer precipitated at pH ranging from 7.5 to 9.7, but protonation of tertiary amine groups (pH < 7.5) and salt forming of masked thiol groups (pH > 9.7) rendered it soluble in water. Our results revealed that a ready available vinyl monomer could be easily clicked onto the biodegradable PLC and its stimuli responsiveness would be reserved. Moreover, the primary and secondary structures of PLC might influence the conformation, thus leading to the unique responsive behavior of the resulted copolymer.

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“…Chemical cross‐linking, through EtO sterilization, was used to form lipoic acid‐modified poly( l ‐lysine) hydrogels by Zhang et al Gamma irradiation appears to be the most attractive method for this approach …”

Section: Sterilization Of Hydrogel‐based Medical Devicesmentioning

confidence: 99%

Sterilization of hydrogels for biomedical applications: A review

et al. 2017

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Despite the beneficial properties and outstanding potential of hydrogels for biomedical applications, several unmet challenges must be overcome, especially regarding to their known sensitivity to conventional sterilization methods. It is crucial for any biomaterial to withstand an efficient sterilization to obtain approval from regulatory organizations and to safely proceed to clinical trials. Sterility assurance minimizes the incidence of medical device-related infections, which still constitute a major concern in health care. In this review, we provide a detailed and comprehensive description of the published work from the past decade regarding the effects of sterilization on different types of hydrogels for biomedical applications. Advances in hydrogel production methods with simultaneous sterilization are also reported. Terminal sterilization methods can induce negative or positive effects on several material properties (e.g., aspect, size, color, chemical structure, mechanical integrity, and biocompatibility). Due to the complexity of factors involved (e.g., material properties, drug stability, sterilization conditions, and parameters), it is important to note the virtual impossibility of predicting the outcome of sterilization methods to determine a set of universal rules. Each system requires case-by-case testing to select the most suitable, effective method that allows for the main properties to remain unaltered. The impact of sterilization methods on the intrinsic properties of these systems is understudied, and further research is needed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2472-2492, 2018.

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Reduction- and pH-Sensitive lipoic acid-modified Poly(l-lysine) and polypeptide/silica hybrid hydrogels/nanogels

Cited by 58 publications

References 56 publications

Benzoic‐Imine‐Based Physiological‐pH‐Responsive Materials for Biomedical Applications

Benzoic‐Imine‐Based Physiological‐pH‐Responsive Materials for Biomedical Applications

Dual stimuli‐responsive polypeptide prepared by thiol‐ene click reaction of poly(l‐cysteine) and N, N‐dimethylaminoethyl acrylate

Sterilization of hydrogels for biomedical applications: A review

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