Reduction in post extraction waiting period for dental implant patients using plasma rich in growth factors: an in vivo study using cone-beam computed tomography

Abstract

ObjectivesThis study examined the effects of plasma-rich growth factors (PRGF) on accelerating bone regeneration/repair in fresh extraction sockets, and determined the quality and quantity of bone by assessing the bone density using cone-beam computed tomography (CBCT).Materials and MethodsTwenty patients, who had undergone bilateral extractions, were included in this study. In one extraction socket, PRGF was used and covered with an autologous fibrin plug. Nothing was used in the opposite side extraction socket. Thirteen weeks post extraction, the level of bone regeneration was evaluated on both sides with CBCT.ResultsAt the end of the study, the mean bone density according to the Hounsfield units (HU) in the control group and PRGF group was 500.05 HU (type III bone type) and 647.95 HU (type II bone type), respectively.ConclusionThis study recommends the use of PRGF in post extraction sites to accelerate the rate of bone regeneration and improve the quality of regenerated bone. The technique to process PRGF was simple compared to previously mentioned techniques used for platelet-rich plasma (PRP) preparation. PRP preparation requires a two-cycle centrifugation procedure, leading to a longer processing time.

Unravelling Alveolar Bone Regeneration Ability of Platelet-Rich Plasma: A Systematic Review with Meta-Analysis

“…PRGF and L-PRP were present in two trials each. In two studies, radiographic density was measured using CBCT [ 18 , 27 ]. Two other trials measured trabecular bone volume (%) [ 29 ] and relative bone density (%) [ 41 ] with radiographic assessment.…”

“…However, the high heterogeneity among PRP preparation protocols has resulted in platelet concentrate products that differ significantly in composition and functions [ 44 ]. Although the main PRP groups (L-PRP and PRGF) have been proven to be effective in socket preservation [ 18 , 27 , 29 , 30 ], evidence from clinical trials suggests more consistent and reproducible data when there is a lack of leukocytes in the preparation [ 22 ].…”

“…Unlike L-PRP, PRGF is characterized by a relatively modest increase in platelet concentration (≈2–3-fold higher than peripheral blood concentration) and by the absence of leukocytes [ 21 , 22 ]. Several randomized clinical trials [ 22 ] (RCTs) have found better soft tissue healing and lower discomfort in PRGF-treated sockets [ 18 , 23 , 24 , 25 , 26 , 27 ]. It is believed that the growth factors released after platelet activation may also promote osteogenic induction and bone regeneration in the alveolar socket.…”

“…It is believed that the growth factors released after platelet activation may also promote osteogenic induction and bone regeneration in the alveolar socket. In this sense, compared to unassisted healing sockets (natural healing or blood clot), a beneficial effect on bone density [ 18 ] and a higher new bone formation [ 27 ] have been described in the PRGF-treated sockets. By contrast, non-randomized prospective study described no benefit in terms of bone density after 4–8 weeks of follow-up [ 28 ].…”

Bone Bonding of Hafnium – A Literature Review

“…To obtain the optimal therapeutic efficacy, these biomolecules need to be immobilized from the surface of implants (gao et al, 2009; bosco et al, 2012). for this purpose, a wide variety of biomolecules such as growth factors, bioactive proteins, enzymes, and non-viral genes (DNAs, rNAs) are currently being evaluated pre-clinically (Tonetti, Hämmerle and european Workshop on Periodontology group C, 2008;Shimono et al, 2010;Quesada-garcía et al, 2012;Arya et al, 2019;mohamed, el-mohandes and el-feky, 2019).…”