2019
DOI: 10.1177/0300060519866606
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Reduction in postoperative hypoparathyroidism following carbon nanoparticle suspension injection combined with parathyroid gland vasculature preservation

Abstract: Objective: We evaluated the effectiveness of carbon nanoparticle suspension injection combined with parathyroid gland vasculature preservation to identify and preserve the parathyroid gland to reduce postoperative hypoparathyroidism following thyroidectomy. Material and Methods: Fifty patients with thyroid tumors received carbon nanoparticle suspension injection combined with parathyroid gland vasculature preservation (group A). Serum calcium and PTH levels were recorded and compared with those of 50 control p… Show more

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Cited by 12 publications
(9 citation statements)
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“…The adsorption mechanism of CNP-EPI is mainly physical adsorption, which absorbs the drug according to its strong adsorption capacity; then its slow-release function is used to slowly release the adsorbed therapeutic drug (17)(18)(19)(20). Due to the strong lymphatic tropism of carbon nanoparticles, adsorbed therapeutic agents can be delivered to lymphatic vessels and lymph nodes, thus playing a role in targeted therapy.…”
Section: Comparison Of Nursing Intervention Resultsmentioning
confidence: 99%
“…The adsorption mechanism of CNP-EPI is mainly physical adsorption, which absorbs the drug according to its strong adsorption capacity; then its slow-release function is used to slowly release the adsorbed therapeutic drug (17)(18)(19)(20). Due to the strong lymphatic tropism of carbon nanoparticles, adsorbed therapeutic agents can be delivered to lymphatic vessels and lymph nodes, thus playing a role in targeted therapy.…”
Section: Comparison Of Nursing Intervention Resultsmentioning
confidence: 99%
“…However, the main disadvantage of this therapy is that the local hyperthermia is easy to damage the recurrent laryngeal nerve on the side of the thyroid, which leads to the hoarseness after treatment. In contrast, using CNSI as the PTA, the injury of recurrent laryngeal nerve would be avoided to a great extent, because CNSI does not stain the parathyroid gland 16,17 . Using this treatment, the thyroid tumor can be ablated by heat from the photothermal conversion of CNSI, while areas without CNSI accumulation do not experience these temperature increases.…”
Section: Resultsmentioning
confidence: 99%
“…In contrast, using CNSI as the PTA, the injury of recurrent laryngeal nerve would be avoided to a great extent, because CNSI does not stain the parathyroid gland. 16 , 17 Using this treatment, the thyroid tumor can be ablated by heat from the photothermal conversion of CNSI, while areas without CNSI accumulation do not experience these temperature increases. Thus, CNSI‐based PTT is extremely suitable for thyroid cancer therapy.…”
Section: Resultsmentioning
confidence: 99%
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“…The mean size of the CNS is 150 nm, allowing it to easily travel through the lymphatic capillary with an average epithelial gap of 120 to 500 nm but not the blood capillary with an average epithelial gap of 20 to 50 nm. Because of this, CNS has been widely used in diverse fields of surgery [ 12 , 13 ]. During the surgical resection of a tumor, CNS particles migrate quickly in lymphatic vessels and accumulate in lymph nodes, staining them black.…”
Section: Discussionmentioning
confidence: 99%