Reduction in the Vascular Bed Volume of Uterine Fibroids after Hormonal Treatment: Evaluation with Dynamic Double-Echo R2* Imaging

Abstract

Purpose: To demonstrate the reduction in vascular bed volume (VBV) of uterineˆbroids after administration of gonadotropin-releasing hormone analogue (GnRHa) using magnetic resonance (MR) imaging including dynamic double-echo R 2 * imaging (DDE-R 2 *I) and to assess the value of DDE-R 2 *I as a predictor of such reduction.Methods: Twenty-one women with uterine intramuralˆbroids underwent MR imaging including DDE-R 2 * I before GnRHa treatment. DDE-R 2 * I was acquired using a single-section, double-echo, fast spoiled gradient recalled acquisition in the steady state (SPGR) sequence. We calculated the area under the curve (AUC) of the signal intensity on R 2 *I within a 3×3-cm 2 region of interest that served to represent the VBV. We repeated MR imaging after 2 administrations of GnRHa and repeated image analyses. We statistically analyzed correlations between (A) pre-treatment AUC (AUC(pre)) and AUC reduction and (B) AUC(pre) and volume reduction.Results: The interval between the 2 MR studies ranged from 56 to 119 days (mean: 80.4 days). The average volume of theˆbroids before GnRHa treatment was 647.8 mL compared with 463.4 mL after the therapy (decreased by an average of 28.5z; Pº0.0001). Meanwhile, measured AUC was reduced by 55.3z (483.4 vs. 206.5; Pº0.0001). AUC(pre) correlated with volume reduction (r＝0.68), but not AUC reduction.Conclusions: We conˆrmed reduction in the VBV ofˆbroids using DDE-R 2 * I. The measurement of AUC(pre) on DDE-R 2 *I aids prediction ofˆbroid volume reduction but correlates poorly with the percentage of AUC reduction.