Reduction of intraocular pressure using timolol orally dissolving strips in the treatment of induced primary open-angle glaucoma in rabbits

Abstract

Objective To enhance bioavailability of timolol (TML) and utilize alternatives for traditional eye drops for more patient compliance, this study was aiming to develop biodegradable orally dissolving strips (ODSs) of TML for treatment of primary open‐angle glaucoma (POAG). Methods Novel ODSs of TML were formulated and optimized using solvent casting method according to full factorial design (31.22). TML ODSs were characterized with respect to many parameters. In‐vivo test was carried out using four groups of 24 New Zealand albino rabbits. POAG was induced by subconjunctival treatment of betamethasone. Histopathological examination and oxidative stress markers assay were carried out. Key findings The optimized formula (F9) exhibited a remarkably 15‐s disintegration time and 96% dissolution rate after 10 min. The results revealed a potent significant inhibitory effect of the optimized TML ODS to reduce IOP in induced rabbits in comparison with control rabbits and TML eye drops‐treated rabbits. The formula showed also high activity against oxidative stress and absence of histopathological changes in iridocorneal angle and cornea. Conclusion The ODSs could be a promising alternative delivery system for eye drops with more compliance to enhance delivery and therapeutic activity of TML in treatment of POAG.

Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats

“…Samples were mixed with potassium bromide (spectroscopic grade) and compressed into disks using hydraulic press before scanning from 4000 to 600 cm −1 was carried out according to El-Feky et al. ( 2020 ).…”

“…The FTIR spectra of TNX-NLCs were recorded using FTIR spectroscopy (Bruker, model alpha, Germany). Samples were mixed with potassium bromide (spectroscopic grade) and compressed into disks using hydraulic press before scanning from 4000 to 600 cm À1 was carried out according to El-Feky et al (2020).…”

Formulation and Development of Oral Fast-Dissolving Films Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers

“…The thickness of each OFDF was measured at five different positions, the center and the four corners, utilizing digital Vernier calipers (Mitutoyo, Kawasaki, Japan). This test was repeated three times, and the average ± SD was calculated [8].…”

“…This test was implemented to ensure a uniform distribution of PX in each OFDF. Each film was dissolved in a 100-mL volumetric flask containing 10 mL ethanol using a vortex (VM-300, Gemmy Industrial Corp., Taiwan) for five minutes [8]. The sample from the resulted liquid was diluted with an appropriate ethanol volume.…”

“…This work aimed to develop and optimize novel palatable oral fast dissolving films (OFDFs) loaded with a paroxetine nanosuspension, to improve PX oral bioavailability by decreasing its broad metabolism in the liver and increasing PX solubility and permeability through the buccal mucosa. OFDFs are palatable, robust, and unique delivery systems that offer several advantages over the other conventional dosage forms available [8]. They offer increased compliance by patients with mental illness, as well as by elderly, pediatric, and developmentally disabled patients.…”