Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2

Zhao, Xiaoqi; Guo, Xuemeng; Pang, Mei; Qiu, Weigen; Luo, Zhenyu; Lin, Qing; Lu, Yichao; Yin, Hang; Wang, Sijie; Liu, Huihui; Zhang, Junlei; Luo, Lihua; You, Jian

doi:10.1007/s12274-023-6030-2

Cited by 2 publications

(1 citation statement)

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“…This result demonstrates the effective incorporation of VNB into the nanostructure. As a result, the VNB compound exhibits a prominent peak attributed to the presence of a carbon–carbon (C–C) group at 1573 cm −1 and a nitrogen–hydrogen (N–H) group in the range of 3500–3000 cm −1 [ 53 ]. The FTIR spectrum of VNB/PDA/PDA/Fe 3 O 4 NPs displays all PDA, SH-PEG, and VNB peaks, indicating the successful formation of a core–shell structure containing these three components.…”

Section: Resultsmentioning

confidence: 99%

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

Özcan,

Hazar Yoruç

2024

Beilstein J. Nanotechnol.

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In this study, a multifunctional therapeutic agent combining chemotherapy and photothermal therapy on a single platform has been developed in the form of vinorelbine-loaded polydopamine-coated iron oxide nanoparticles. Vinorelbine (VNB) is loaded on the surface of iron oxide nanoparticles produced by a solvothermal technique after coating with polydopamine (PDA) with varying weight ratios as a result of dopamine polymerisation and covalent bonding of thiol-polyethylene glycol (SH-PEG). The VNB/PDA/Fe3O4 nanoparticles have a saturation magnetisation value of 60.40 emu/g in vibrating sample magnetometry, which proves their magnetisation. Vinorelbine, which is used as an effective cancer therapy agent, is included in the nanocomposite structure, and in vitro drug release studies under different pH conditions (pH 5.5 and 7.4) and photothermal activity at 808 nm NIR laser irradiation are investigated. The comprehensive integration of precise multifunctional nanoparticles design, magnetic response, and controlled drug release with photothermal effect brings a different perspective to advanced cancer treatment research.

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Section: Resultsmentioning

confidence: 99%