Reduktion der Tinnituslautstärke

Schilling, Achim; Krauß, Patrick; Hannemann, Ronny; Schulze, Holger; Tziridis, Konstantin

doi:10.1007/s00106-020-00963-5

Cited by 20 publications

(27 citation statements)

References 24 publications

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“…Both effects are in line with our hypothesis that stochastic resonance plays a major role in the auditory system. The converging evidence from numerous empirical (for an overview see 7 , 21 ) and theoretical studies 5 , 6 , 19 indicates that the auditory system actually exploits stochastic resonance and actively tunes the intensity of the required neuronal noise by adjusting the somatosensory input to the dorsal cochlear nucleus. By that, stochastic resonance contributes crucially to the auditory system’s ability to adapt to changing sound pressure levels.…”

Section: Discussionmentioning

confidence: 99%

“…In terms of time scale, the induced phantom sounds—as a side effect of the physiological mechanism to compensate for reduced auditory input—are at an intermediate level between chronic lifelong tinnitus on the one end and the only seconds lasting Zwicker tone illusions 20 on the other end of the spectrum. Within the stochastic resonance framework of auditory processing, all these phantom sounds are caused by the same neuronal mechanism and do just occur on different time scales 21 .…”

Section: Discussionmentioning

confidence: 99%

“…This neural hyperactivity in turn, was found to be correlated with subjective tinnitus in many studies. Our model provides a unified mechanistic explanation of how hearing loss, phantom perceptions like tinnitus or the Zwicker tone illusion 20 , and neural hyperactivity are related to each other 21 , namely that these phantom perceptions are side effects of the physiological neuronal mechanism to (partly) restore hearing thresholds. Therefore, our model provides a mechanistic explanation why patients with hearing loss and with tinnitus on average have better hearing thresholds than patients with hearing loss and without tinnitus 22 , i.e.…”

Section: Introductionmentioning

confidence: 98%

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Simulated transient hearing loss improves auditory sensitivity

Krauß

Tziridis

2021

Sci Rep

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Recently, it was proposed that a processing principle called adaptive stochastic resonance plays a major role in the auditory system, and serves to maintain optimal sensitivity even to highly variable sound pressure levels. As a side effect, in case of reduced auditory input, such as permanent hearing loss or frequency specific deprivation, this mechanism may eventually lead to the perception of phantom sounds like tinnitus or the Zwicker tone illusion. Using computational modeling, the biological plausibility of this processing principle was already demonstrated. Here, we provide experimental results that further support the stochastic resonance model of auditory perception. In particular, Mongolian gerbils were exposed to moderate intensity, non-damaging long-term notched noise, which mimics hearing loss for frequencies within the notch. Remarkably, the animals developed significantly increased sensitivity, i.e. improved hearing thresholds, for the frequency centered within the notch, but not for frequencies outside the notch. In addition, most animals treated with the new paradigm showed identical behavioral signs of phantom sound perception (tinnitus) as animals with acoustic trauma induced tinnitus. In contrast, animals treated with broadband noise as a control condition did not show any significant threshold change, nor behavioral signs of phantom sound perception.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Simulated transient hearing loss improves auditory sensitivity

Krauß

Tziridis

2021

Sci Rep

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“…Until today, several tinnitus models are being debated, although, due to developments in basic neuroscience, a central origin of tinnitusrelated activity seems to have replaced the former peripheral hypothesis (Noreña and Farley, 2013). In particular, three main models, which are based on altered lateral inhibition, homeostatic plasticity, or stochastic resonance (SR) (Gerken, 1996;Eggermont and Roberts, 2004;Schaette and McAlpine, 2011;Ahlf et al, 2012;Tziridis et al, 2015;Leaver et al, 2016;Vanneste and De Ridder, 2016;Schilling et al, 2020), propose a central origin of tinnitus, resulting from damage to the cochlea as the initial step in tinnitus development.…”

Section: Introductionmentioning

confidence: 99%

Salicylate-Induced Changes in Hearing Thresholds in Mongolian Gerbils Are Correlated With Tinnitus Frequency but Not With Tinnitus Strength

Lanaia

Tziridis

Schulze

2021

Front. Behav. Neurosci.

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Tinnitus is an auditory phantom percept without external sound sources. Despite the high prevalence and tinnitus-associated distress of affected patients, the pathophysiology of tinnitus remains largely unknown, making prevention and treatments difficult to develop. In order to elucidate the pathophysiology of tinnitus, animal models are used where tinnitus is induced either permanently by noise trauma or transiently by the application of salicylate. In a model of trauma-induced tinnitus, we have suggested a central origin of tinnitus-related development of neuronal hyperactivity based on stochastic resonance (SR). SR refers to the physiological phenomenon that weak subthreshold signals for given sensors (or synapses) can still be detected and transmitted if appropriate noise is added to the input of the sensor. The main objective of this study was to characterize the neurophysiological and behavioral effects during salicylate-induced tinnitus and compare these to the conditions within the trauma model. Our data show, in line with the pharmacokinetics, that hearing thresholds generally increase 2 h after salicylate injections. This increase was significantly stronger within the region of best hearing compared to other frequencies. Furthermore, animals showed behavioral signs of tinnitus during that time window and frequency range as assessed by gap prepulse inhibition of the acoustic startle reflex (GPIAS). In contrast to animals with noise trauma-induced tinnitus, salicylate-induced tinnitus animals showed no correlation between hearing thresholds and behavioral signs of tinnitus, indicating that the development of tinnitus after salicylate injection is not based on SR as proposed for the trauma model. In other words, salicylate-induced tinnitus and noise trauma-induced tinnitus are not based on the same neurophysiological mechanism.

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“…Tinnitus afflicts approximately 15% of the general population worldwide, and there is currently no cure for this disorder. Attempts have been made to ameliorate tinnitus with individually applied spectrally optimized nearthreshold noise (Schilling et al, 2021), with most patients stating that subjective tinnitus loudness was suppressed during the noise stimulation.…”

Section: Other Novel Materials For Treating Auditory-related Conditionsmentioning

confidence: 99%

Application of New Materials in Auditory Disease Treatment

Cai

et al. 2022

Front. Cell. Neurosci.

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Auditory diseases are disabling public health problems that afflict a significant number of people worldwide, and they remain largely incurable until now. Driven by continuous innovation in the fields of chemistry, physics, and materials science, novel materials that can be applied to hearing diseases are constantly emerging. In contrast to conventional materials, new materials are easily accessible, inexpensive, non-invasive, with better acoustic therapy effects and weaker immune rejection after implantation. When new materials are used to treat auditory diseases, the wound healing, infection prevention, disease recurrence, hair cell regeneration, functional recovery, and other aspects have been significantly improved. Despite these advances, clinical success has been limited, largely due to issues regarding a lack of effectiveness and safety. With ever-developing scientific research, more novel materials will be facilitated into clinical use in the future.

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Reduktion der Tinnituslautstärke

Cited by 20 publications

References 24 publications

Simulated transient hearing loss improves auditory sensitivity

Simulated transient hearing loss improves auditory sensitivity

Salicylate-Induced Changes in Hearing Thresholds in Mongolian Gerbils Are Correlated With Tinnitus Frequency but Not With Tinnitus Strength

Application of New Materials in Auditory Disease Treatment

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