Reference charts for fetal corpus callosum length in the early second trimester: a prospective cross-sectional study

Abstract

Objective: This study aimed to establish normal reference ranges for fetal corpus callosum (CC) measured by prenatal ultrasonography (USG) between 16-25 weeks of gestation in healthy fetuses. Material and Method: A total of 809 fetuses in the second trimester were evaluated by transabdominal USG. All measurements were obtained by a single clinician. Results: Based on the correlation analysis, a significant positive correlation was found between gestational week and CC (r=0.907; p<0.001). Conclusion: We anticipate that the reference intervals obtained from healthy fetuses will help clinicians who are interested in neurosonography to detect CC abnormalities at an early stage.