Reference Data of the Spanish Memory Binding Test in a Midlife Population from the ALFA STUDY (Alzheimer’s and Family)

Gramunt, Nina; Buschke, Herman; Sánchez‐Benavides, Gonzalo; Lipton, Richard B.; Peña-Casanova, Jordi; Diéguez-Vide, Faustino; Masramon, Xavier; Gispert, Juan Domingo; Fauria, Karine; Camı́, Jordi; Molinuevo, José Luís

doi:10.3233/jad-150237

Cited by 22 publications

(11 citation statements)

References 53 publications

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“…Furthermore, a clear ceiling effect is observable for most of the cognitive tests used for screening purposes: for example, the mean score for the MMSE is of 29 (of 30), 7.8 (of 8.0) for the MIS and 70 (of 70) for the TO-BTII ( Table 2 ). On the other hand, the neuropsychological tests included in the cognitive experimental battery (namely the MBT and the WAIS-IV subtests) are more complex showing no ceiling effects, as shown for the MBT when validated [32] , [50] . In fact, the MBT was designed with the intention of overcoming some limitations in the sensitivity of the widely used FCSRT in the detection of subtle episodic memory changes due to AD [31] .…”

Section: Discussionmentioning

confidence: 99%

“…After initial evaluation, eligible subjects were administered an experimental cognitive test battery for the potential detection of early impairment in longitudinal follow-ups. This battery assessed episodic verbal memory [the Memory Binding Test [31] , [32] (MBT)], psychomotor speed, visual processing, executive function, and non-verbal and verbal reasoning (Coding, Visual Puzzles, Digit Span, Matrix Reasoning, and Similarities of the WAIS IV [33] ).…”

Section: Methodsmentioning

confidence: 99%

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The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease

Molinuevo

Gramunt

Gispert

et al. 2016

A&D Transl Res & Clin Interv

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IntroductionThe preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project, including the ALFA registry and parent cohort and the nested ALFA+ cohort study.MethodsThe ALFA parent cohort baseline visit included full cognitive evaluation, lifestyle habits questionnaires, DNA extraction, and MRI. The nested ALFA+ study adds wet and imaging biomarkers for deeper phenotyping.ResultsA total of 2743 participants aged 45 to 74 years were included in the ALFA parent cohort. We show that this cohort, mostly composed of cognitively normal offspring of AD patients, is enriched for AD genetic risk factors.DiscussionThe ALFA project represents a valuable infrastructure that will leverage with different studies and trials to prevent AD. The longitudinal ALFA+ cohort will serve to untangle the natural history of the disease and to model the preclinical stages to develop successful trials.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease

Molinuevo

Gramunt

Gispert

et al. 2016

A&D Transl Res & Clin Interv

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129

150

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“…This test assesses immediate and delayed retention of verbal information (after a lapse of 25–35 min) through a controlled learning process of two lists of 16 words belonging to 16 different semantic categories presented in the same order. Further detail on the administration procedure of the MBT and an exhaustive description of each of the variables can be found in (Gramunt et al, ). We analyzed seven MBT main outcomes corresponding to two main areas: learning and immediate recall, and delayed recall.…”

Section: Methodsmentioning

confidence: 99%

White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants

Brugulat‐Serrat

Salvadó

Operto

et al. 2019

Human Brain Mapping

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White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship between cerebral patterns of GMv and cognition in 521 (mean age 57.7 years) cognitively unimpaired middle‐aged individuals. Episodic memory (EM) was measured with the Memory Binding Test and executive functions (EF) using five WAIS‐IV subtests. WMH were automatically determined from T2 and FLAIR sequences and characterized using diffusion‐weighted imaging (DWI) parameters. WMH volume was entered as a mediator in a voxel‐wise mediation analysis relating GMv and cognitive performance (with both EM and EF composites and the individual tests independently). The mediation model was corrected by age, sex, education, number of Apolipoprotein E (APOE)‐ε4 alleles and total intracranial volume. We found that even at very low levels of WMH burden in the cohort (median volume of 3.2 mL), higher WMH lesion volume was significantly associated with a widespread pattern of lower GMv in temporal, frontal, and cerebellar areas. WMH mediated the relationship between GMv and EF, mainly driven by processing speed, but not EM. DWI parameters in these lesions were compatible with incipient demyelination and axonal loss. These findings lead to the reflection on the relevance of the control of cardiovascular risk factors in middle‐aged individuals as a valuable preventive strategy to reduce or delay cognitive decline.

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“…Spanish translation and transcultural adaptation of the MBT. Although there is a Spanish version of the MBT for Spain 44 - 46 and another for Colombia, 47 some words are infrequent in Argentina (zumo, laton, taburete, alicates, ensaimada, aspirador, colgantes, vitrina, cipres, among others). These could have affected the Encoding Specificity and Binding, two important aspects of the MBT.…”

Section: Methodsmentioning

confidence: 99%

Validation of the Argentine version of the Memory Binding Test (MBT) for Early Detection of Mild Cognitive Impairment

Román¹,

Iturry²,

Rojas³

et al. 2016

Dement. neuropsychol.

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Background: "Forgetfulness" is frequent in normal aging and characteristic of the early stages of dementia syndromes. The episodic memory test is central for detecting amnestic mild cognitive impairment (MCI). The Memory Binding Test (MBT) is a simple, easy and brief memory test to detect the early stage of episodic memory impairment. Objective: To validate the Argentine version of the MBT in a Latin American population and to estimate the diagnostic accuracy as a tool for early detection of MCI. Methods: 88 subjects (46 healthy controls and 42 patients with amnestic MCI) matched for age and educational level were evaluated by an extensive neuropsychological battery and the memory binding test. Results: A significantly better performance was detected in the control group; all MBT scales were predictive of MCI diagnosis (p<.01). The MBT showed high sensitivity (69%) and high specificity (88%), with a PPV of 93% and a NPV of 55% for associative paired recall. A statistically significant difference (c2=14,164, p<.001) was obtained when comparing the area under the curve (AUC) of the MBT (0.88) and the MMSE (0.70). Conclusion: The Argentine version of the MBT correlated significantly with the MMSE and the memory battery and is a useful tool in the detection of MCI. The operating characteristics of the MBT are well suited, surpassing other tests commonly used for detecting MCI.

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Reference Data of the Spanish Memory Binding Test in a Midlife Population from the ALFA STUDY (Alzheimer’s and Family)

Abstract: This study contributes with reference data for the MBT providing the necessary adjustments for sociodemographic characteristics. Our data may prove to be useful for detecting asymptomatic at-risk candidates for secondary prevention studies of AD.

Cited by 22 publications

References 53 publications

The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease

The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease

White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants

Validation of the Argentine version of the Memory Binding Test (MBT) for Early Detection of Mild Cognitive Impairment

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