Reference Interval for Urinary Neutrophil Gelatinase-Associated Lipocalin in Healthy Adults in Jiangsu Region in Eastern China: A Multicenter Study

Abstract

Aim: We explored the concentrations of urinary neutrophil gelatinase-associated lipocalin (NGAL) in healthy adults in the Jiangsu region in Eastern China and established a reference interval using latex-enhanced immunoturbidimetry to provide important guidelines for the interpretation and application of urinary NGAL in clinical practice. Methods: In total, 1970 eligible subjects from four regions were included in this study. The urinary NGAL levels were measured using an AU5800 automatic biochemical analyzer with its matched reagents. The urinary NGAL reference interval was established using the one-sided percentile method (95th percentile). Results: The urinary NGAL data were non-normally distributed. The urinary NGAL levels were not significantly different by sex or age. Therefore, the urinary NGAL reference interval in healthy adults in the Jiangsu region in Eastern China was <87.5 ng/ml (95th percentile of the upper limit). Conclusion: Urinary NGAL reference interval will play an important role in promoting the clinical value of urinary NGAL.

Construction of a nomogram model to predict the development of retinopathy in type 2 diabetes mellitus based on systemic inflammatory indicators

“…Neutrophils, for instance, have nonspecific inflammatory responses. Lymphocytes, on the other hand, can be modulated by nutritional status and stress status to inhibit the inflammatory response [10]. With T2DM, hyperglycemia promotes transcription factors expression, leading to neutrophilia and protective lymphocyte reduction [11].…”