Reference Intervals and Age‐related Changes for Platelet Count, Mean Platelet Volume and Plateletcrit in Healthy Pre‐weaning Piglets in Italy

Faustini, M.; Bronzo, V.; Maffeo, G.; Russo, Vincenzo; Munari, E.; Vigo, D.

doi:10.1046/j.1439-0442.2003.00581.x

Cited by 11 publications

(12 citation statements)

References 20 publications

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“…Blood specimens were immediately divided into 2 portions as described in the literature. 1,6 The first portion of blood (1 mL) was transferred into plastic tubes with K 2 -EDTA (dipotassium salt of ethylenediaminetetra-acetic acid).…”

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confidence: 99%

“…There are several reports concerning both primary (platelet) and secondary (plasma) hemostasis in pigs, based on experiments carried out on pigs of various ages and different genetic lines. 5,6,11,13,14,17,18,22,24 Most of the data refer to hematologic and plasma biochemistry parameters in pigs, and often only single parameters of hemostasis have been addressed. Moreover, the current knowledge of swine hemostasis seems to be insufficient for the broader use of a swine model for biomedical research.…”

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confidence: 99%

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Age-related changes of platelet and plasma coagulation parameters in young pigs

et al. 2016

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Abstract. The literature on hemostatic processes in swine is sparse and often fragmentary; hence, we conducted our study to characterize age-related changes in selected parameters of primary and secondary hemostasis in 50 growing pigs between day 2 and week 24 of age. We measured platelet count (PLT), mean platelet volume, platelet-to-large cell ratio, prothrombin time, activated partial thromboplastin time (aPTT), thrombin time (TT), and fibrinogen concentration. Among primary hemostasis parameters, PLT underwent the largest fluctuation with the animals' age, ranging from 340 to 730 × 10 9 /L. However, statistical significance was only detected for 4-week-old piglets compared to 18-week-old animals. Of the secondary hemostasis parameters measured, TT and aPTT were the most changeable. Activated partial thromboplastin time displayed a characteristic biphasic course, being relatively short before week 5 of age (17.8-19.9 s) and then becoming much longer (28.7-52.5 s). The aPTTs measured in animals 6 weeks of age and older were statistically different (p < 0.01) from those in younger piglets. The 2 main components of hemostasis, platelet hemostasis and plasma coagulation, did not develop at the same time. It took much longer for secondary hemostasis to stabilize, whereas platelet parameters were stable early in life.

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Age-related changes of platelet and plasma coagulation parameters in young pigs

et al. 2016

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“…However, to our knowledge, there have been few reports about the blood biochemistry for specific pathogen-free (SPF) miniature pigs, although simple hematology tests have been conducted in germ-free Minnesota miniature pigs [9,10]. In addition, normal values for blood biochemistry may be age-dependent, and only age-related changes in platelet activity have previously been reported [11,12]. …”

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Analysis of reference interval and age-related changes in serum biochemistry and hematology in the specific pathogen free miniature pig

et al. 2012

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We analyzed 72 items related to serum biochemistry and hematology in 85 specific pathogen-free (SPF) Seoul National University (SNU) miniature pigs aged 1- to 36-months which originated from a Minnesota miniature pig. Almost all examined items were similar between male and female pigs. However, some items such as Cr level, B/C ratio, C.R.F, LDH, LAP and T4 were significantly different between male and female pigs (P<0.05). Thirty four examined items showed age-related changes, and the significant changes were observed in animals less than six months old. The values for BUN, K, uric acid, Ca, Ca++, and Pi were significantly higher in pigs younger than six months of age, which might reflect poor kidney function in young pigs. Additionally, TIBC, UIBC and RDW were significantly higher in young pigs, and RBC, Hb, HCT, MCHC and MCV were significantly lower in young pigs, thus indicating a similar physiology of iron deficiency anemia. These age-related specific phenotypes seemed to be normal, but it should be considered in the long-term experiment using the young pigs. In conclusion, in this study, we defined the normal reference intervals for SPF SNU miniature pigs, and we also determined that there are some physiological differences between the pig genders and ages. This study provides fundamental data for use in experiments involving SPF SNU miniature pigs.

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“…The different parameters analysed to assess the general health status of the piglets showed some differences but also high variability. Few authors attribute this nding to the immune system development during the growth of piglets [15,33]. On day 3 postnatally, females derived from the ET group showed signi cantly greater values in the concentration of RBC, Hb and HTC compared to the AI group.…”

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Impact of Embryo Transfer on the phenotype of the offspring in pigs

París-Oller¹,

Matás²,

Romar³

et al. 2020

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BackgroundThe increased use of assisted reproductive technologies led to a higher risk of specific alterations in the offspring, as already described in human and other mammalian species. Nonetheless, it is yet to be totally understood how and which specific techniques are inducing these changes. The use of animal models may represent an advantage to find out answers to these questions due to the minimization of confounding factors. The pig is not only a great human reproductive model, but it is also of interest in the livestock industry to develop further technologies that may enhance meat production. This study was designed to decipher the impact of one of these technologies, namely embryo transfer, on mother´s reproductive performance and on the phenotype of the offspring in pigs.ResultsEmbryo transfer of in vivo derived embryos (ET) showed similar results in terms of pregnancy length, litter size and total litter weight per sow than sows artificially inseminated (AI). Bodyweight at birth was higher for ET-females than AI-females, but this difference was no longer observed at day 15 of postnatal life. Some of the major findings after haematological analyses were that concentration of red blood cells, haemoglobin and haematocrit in female-ET piglets at day 3 showed higher values than AI-females. Additionally, higher concentration of white blood cells was found at day 3 in both ET-derived piglets (males and females) in comparison to AI-piglets. Biochemical analysis showed a higher level of albumin at day 3 for ET-derived male piglets than AI but ET-females showed lower levels of bilirubin than AI in the same day. Despite the statistical differences between groups, all values were within the normal ranges, so that we cannot give them any clinical significance.ConclusionsPiglets derived from in vivo embryo transfer seem to be phenotypically similar, which provides evidence that the embryo transfer procedure is a safe technique, without relevant health implications to the offspring. Additionally, these findings may be of interest to the pig industry regarding the reference values provided for haematological and biochemical parameters in this species.

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Reference Intervals and Age‐related Changes for Platelet Count, Mean Platelet Volume and Plateletcrit in Healthy Pre‐weaning Piglets in Italy

Cited by 11 publications

References 20 publications

Age-related changes of platelet and plasma coagulation parameters in young pigs

Age-related changes of platelet and plasma coagulation parameters in young pigs

Analysis of reference interval and age-related changes in serum biochemistry and hematology in the specific pathogen free miniature pig

Impact of Embryo Transfer on the phenotype of the offspring in pigs

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