Reference range for micronutrients and nutritional marker proteins in cord blood of neonates appropriated for gestational ages

Galinier, Anne; Périquet, B.; Lambert, Willy E.; García, Jesús Felicidades; Assouline, Corinne; Rolland, M; Thouvenot, J

doi:10.1016/j.earlhumdev.2005.01.007

Cited by 61 publications

(42 citation statements)

References 44 publications

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“…The low ceruloplasmin values obtained in the present study are, nevertheless, within the reported pediatric reference ranges [20,24]. On the other hand, the mean Cu/ceruloplasmin ratios of 5.64 (late preterm mothers) and 6.48 (term mothers) are within the range 5.08-8.55 µmol/g and 5.2-7.3 µmol/g, respectively, reported for adults by Twomey et al [7] and Beetham [8].…”

Section: Discussionsupporting

confidence: 73%

“…That the mean values for cord blood ceruloplasmin, copper, zinc, apo A-I, and cholesterol of both groups of neonates were all within the pediatric reference ranges [20,24] would indicate: (1) satisfactory hepatic synthesis of ceruloplasmin, (2) adequate placental transfer of microminerals from mothers to fetuses, and (3) absence of the familial hyperlipidemias in the neonates. Although the maternal apo A-I and apo B values obtained in this study were within the reference ranges, their cholesterol values were in the moderate risk range [20].…”

Section: Discussionmentioning

confidence: 98%

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Erythrocyte Indices, Microminerals and Ratios, Antioxidants and Lipids in Centrum Materna Diet-Supplemented Omani Mothers

Abiaka

Machado

Mathew

et al. 2008

Biol Trace Elem Res

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Venous (maternal) and cord blood (neonatal) samples of Omani women who had a daily supplement of Centrum Materna multivitamin and multimineral tablet throughout pregnancy were investigated at late preterm (n=37) and at term (n=37) delivery for erythrocyte indices, micromineral, antioxidant, and lipid values. Hemoglobin (Hb), hematocrit (HCT), mean cell volume (MCV), red cell distribution width (RDW), copper (Cu), zinc (Zn), ceruloplasmin, erythrocyte Cu-Zn superoxide dismutase (Cu-Zn SOD), cholesterol, apolipoprotein (apo) A-I and apo B were measured by appropriate analytical systems. Cu/zinc and Cu/ceruloplasmin ratios were calculated. The erythrocyte indices were normal in neonatal blood but showed borderline anemia in maternal blood of both groups. There were significantly decreased values of Cu (P=0.012), Zn (P=0.001), apo A-I (P=0.029), and Cu/ceruloplasmin ratio (P=0.032) in late preterm compared to term mothers. Significantly decreased values of Cu (P=0.003), ceruloplasmin (P<0.0001), apo A-I (P=0.024), and Cu/Zn ratio (P=007) were observed in late preterm relative to term neonates. Late preterm mothers were significantly younger (P=0.027) than term mothers. Maternal age correlated positively with apo A-I (r=0.424, P=0.012) and negatively with Cu/Zn ratio (r=-0.353, P=0.040). The findings suggest that with daily dietary Centrum Materna supplementation throughout pregnancy, hematological indices were maintained within normal in mothers and neonates, but the levels of microminerals and micromineral ratios were subnormal in late preterm mothers and their neonates.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 98%

Erythrocyte Indices, Microminerals and Ratios, Antioxidants and Lipids in Centrum Materna Diet-Supplemented Omani Mothers

Abiaka

Machado

Mathew

et al. 2008

Biol Trace Elem Res

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“…The plasma albumin concentration is a routinely measured variable in the neonatal intensive care unit (NICU) and is often found to be low in ill premature infants (1,2). Albumin, produced by the liver, has several important roles in neonatal physiology (3,4): it is the main preserver of the colloid osmotic pressure in plasma (Ȃ75%), it functions as an anticoagulant, and it is an important binding transporter of certain metabolites, eg, bilirubin, free fatty acids, and drugs.…”

Section: Introductionmentioning

confidence: 99%

Albumin synthesis in premature neonates is stimulated by parenterally administered amino acids during the first days of life

Akker¹,

Braake²,

Schierbeek³

et al. 2007

The American Journal of Clinical Nutrition

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Background:We recently showed that parenteral administration of amino acids to premature infants immediately after birth is safe and results in a positive nitrogen balance and increased whole-body protein synthesis. However, we did not determine organ-specific effects; albumin, produced by the liver, is an important protein, but its concentration is often low in premature neonates during the first few days after birth. Objective: The objective of the study was to test the hypothesis that the fractional and absolute albumin synthesis rates would increase with the administration of amino acids after birth, even at low nonprotein energy intake. Design: Premature infants (1500 g birth weight), who were on ventilation, received from birth onward either glucose only (control group, n ҃ 7) or glucose and 2.4 g amino acid ⅐ kg Ҁ1 ⅐ d Ҁ1 (intervention group, n ҃ 8). On postnatal day 2, all infants received a primed continuous infusion of [1-13 C]leucine, and mass spectrometry techniques were used to determine the incorporation of the leucine into albumin. Results are expressed as medians and 25th and 75th percentiles. Results: Albumin fractional synthesis rates in the intervention group were significantly higher than those in the control group [22.9% (17.6 -28.0%)/d and 12.6% (11.0 -19.4%)/d, respectively; P ҃ 0.029]. Likewise, the albumin absolute synthesis rates in the intervention group were significantly higher than those in the control group [228 (187-289)

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“…1 After serial high-dose injections of retinyl palmitate, circulating retinyl esters increased markedly. Moreover, the molar retinol-to-RBP4 ratios exceeded 1.0 in a considerable proportion of infants, suggesting that retinol transport in serum is also achieved by transport proteins other than RBP4.…”

Section: Discussionmentioning

confidence: 99%

“…In term infants, retinol concentrations in cord blood were found to be 38% higher than in preterm infants. 1 Lung immaturity accounts for much of the mortality and morbidity in very-low-birth-weight (VLBW) infants (birth weight o1500 g). The final step of pulmonary differentiation is facilitated by vitamin A. VLBW infants have less bronchopulmonary dysplasia (BPD) when given high-dose vitamin A intramuscular (i.m.)…”

mentioning

confidence: 99%

Characterization of the vitamin A transport in preterm infants after repeated high-dose vitamin A injections

et al. 2014

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Reference range for micronutrients and nutritional marker proteins in cord blood of neonates appropriated for gestational ages

Cited by 61 publications

References 44 publications

Erythrocyte Indices, Microminerals and Ratios, Antioxidants and Lipids in Centrum Materna Diet-Supplemented Omani Mothers

Erythrocyte Indices, Microminerals and Ratios, Antioxidants and Lipids in Centrum Materna Diet-Supplemented Omani Mothers

Albumin synthesis in premature neonates is stimulated by parenterally administered amino acids during the first days of life

Characterization of the vitamin A transport in preterm infants after repeated high-dose vitamin A injections

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