Reference range of thyroid hormones in healthy school-age children: Country-wide data from India

Marwaha, Raman K.; Tandon, Nikhil; Desai, Ankush; Kanwar, Ratnesh; Aggarwal, Rashmi; Sastry, A. V. R.; Singh, Simar Rajan; Narang, Amit; Ganguly, S. K.; Kalaivani, Mani

doi:10.1016/j.clinbiochem.2009.03.001

Cited by 26 publications

(28 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As for TSH, both the upper and lower limits remained practically unchanged throughout all age groups of 4 years or older; the results are noticeably different from those of our study despite the subject age group is same. However, according to past overseas reports listed in Table 3, except for the study reported by Marwaha RK et al [9], the reference range of TSH decreased more or less uniformly with advancing age, consistent with our finding. The results were comparable between iodine-sufficient regions and iodine-deficient regions.…”

Section: Discussionsupporting

confidence: 82%

Determination of pediatric reference levels of FT3, FT4 and TSH measured with ECLusys kits

et al. 2013

View full text Add to dashboard Cite

It Is essentIal to establish reference ranges for pediatric age groups to diagnose abnormalities of thyroid function in children. In Japan, reference ranges for thyroid hormones free triiodothyronine (FT3) and free thyroxine (FT4) as determined by radioimmunoassay (RIA) and reference ranges for thyroid stimulating hormone (TSH) as determined by immunoradiometric assay (IRMA) have been reported [1,2], even though they have been derived from assays of rather small sample sizes. Subsequently, a large-scale study was conducted in 1996 by a Pediatric Reference Range Study Group and reference ranges for pediatric age groups were reported [3]. More than one and half decades have elapsed since then, and reference ranges based abstract. Reference ranges for serum thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in children were set using the assay kits currently used in clinical settings. A total of 342 children (111 males and 231 females) who were negative for antithyroid antibodies (TgAb, TPOAb) and were found to have no abnormalities on ultrasonographic examination of the thyroid gland were divided into 6 age groups: 4-6 years (45 children), 7-8 years (40), 9-10 years (53), 11-12 years (65), 13-14 years (83), and 15 years (56) for the study. FT3, FT4 and TSH levels were determined by electrochemiluminescence immunoassay (ECLIA) (ECLusys FT3, FT4 and TSH).The reference range for FT3 (pg/mL) was 2.91-4.70 for the age group of 4-6 years, 3.10-5.10 for the age group of 7-8 years, 3.10-4.87 for the age group of 9-10 years, 2.78-4.90 for the age group of 11-12 years, 2.77-4.59 for the age group of 13-14 years, and 2.50-4.64 for the age group of 15 years . The reference range for FT4 (ng/dL) was 1.

show abstract

Section: Discussionsupporting

confidence: 82%

Determination of pediatric reference levels of FT3, FT4 and TSH measured with ECLusys kits

et al. 2013

View full text Add to dashboard Cite

show abstract

“…en niños, el eje hipotálamo-hipófisis-tiroides va progresivamente madurando, lo que se refleja en una continua disminución de la relación tsh/t4l desde la gestación hasta completar la pubertad. Se ha descrito que sería la edad más que el estado puberal lo que explicaría los niveles elevados de tsh encontrados en edades tempranas 22,33 . es por esto que la academia nacional de Bioquímica Clínica de EEUU recomienda usar límites de referencia específicos para la edad de los pacientes, en las pruebas de función tiroidea 34 .…”

Section: Discussionunclassified

Niveles de hormonas tiroideas en niños obesos

et al. 2014

Rev. chil. pediatr.

View full text Add to dashboard Cite

“…Marwaha ve arkadaşlarının Hindistan'da yapılmış iki ça-lışmasında beş ile onaltı yaş arası çocuklarda TSH'nın ortalama değeri 3,17 mIU/L, 97 persentil değeri 7,5 mIU/L ölçüldüğü belirtilmiştir [11][12].…”

Section: şEkil 1 çOcuklarda Hipotiroidizmin Durumuunclassified

Insidious danger in childhood era's: subclinical hypothyroidism

2017

View full text Add to dashboard Cite

Insidious danger in childhood era's; subclinical hypothyroidism erleme d Öz Tiroid hormonları; santral sinir sistemi gelişimi, büyüme, gelişme, vücut ısısı regülasyonu, lipit, karbonhidrat ve enerji metabolizması, iskelet sistemi üzerinde önemli role sahiptir. Diğer yönden çocukluk çağında santral sinir sistemi myelinizasyonunda görevli olduğu için önemi farklıdır. Subklinik hipotiroidi, serum tiroid stimulan hormon seviyesinin orta düzeyde artması ile birlikte serum tiroid hormon seviyelerinin normal referans laboratuvar aralı-ğında olmasıdır. Çocuklarda %2 oranında görülmektedir. Etiyolojisinin büyük bir kısmını otoimmün tiroidit ve iyot eksikliği oluşturmaktadır. Asemptomatik olguların zamanında tanımlanması ve tedavisi önemlidir. Olgularda guatr, büyüme-gelişme geriliği veya duraksaması, ders başarısında azalma, negativizm, depresyon, obezite, demir eksikliği anemisi, dislipidemi, kemik yaşı geriliğinde levotiroksin tedavisi başlanması uygundur. Anahtar sözcükler: Çocukluk çağı, subklinik hipotiroidizm AbstractThyroid hormones have an important role on the central nervous system, growth, development, body temperature regulation, metabolism of lipid, carbohydrate and energy, musculoskeletal system. The other hand, it has a different importance for its role in the myelinization of the central nervous system during the childhood period. Subclinical hypothyroidism (SH), is diagnosed when peripheral thyroid hormone levels are within normal reference laboratory range but serum thyroid-stimulating hormone levels are mildly elevated. Prevalance of subclinical hypothyroidism in chilhood is seen about %2. The majority of its etiology is due to the autoimmune thyroiditis and iodine deficiency. It is important to diagnose and treat the asymptomatic cases in a timely manner. Thyroxin treatment should be started if goiter, growth velocity is slowed down, decline in school success, negativism, depression, obesity, refractory iron deficiency anemia dyslipidemia, bone age retardation.

show abstract

Reference range of thyroid hormones in healthy school-age children: Country-wide data from India

Cited by 26 publications

References 17 publications

Determination of pediatric reference levels of FT3, FT4 and TSH measured with ECLusys kits

Determination of pediatric reference levels of FT3, FT4 and TSH measured with ECLusys kits

Niveles de hormonas tiroideas en niños obesos

Insidious danger in childhood era's: subclinical hypothyroidism

Contact Info

Product

Resources

About