Reference range of thyroid hormones in normal Indian school‐age children

Marwaha, Raman K.; Tandon, Nikhil; Desai, Ankush; Kanwar, Ratnesh; Grewal, Khushi; Aggarwal, Rashmi; Sastry, A. V. R.; Singh, Simar Rajan; Ganguly, S. K.; Kalaivani, Mani

doi:10.1111/j.1365-2265.2007.03048.x

Cited by 28 publications

(31 citation statements)

References 28 publications

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“…We have previously suggested that this phenomenon could be an in vivo reflection of the previously reported increase in the in vitro activity of deiodinases in response to increasing TSH concentrations (3). Another sidefinding was the difference between the genders in thyroid hormone levels that is in agreement with one previous study and differs somewhat from the two others (10,11,12). From our results (Tables 1 and 2), it appears that beyond age 40, the effect of TSH to increase T3 production from T4 becomes less pronounced and may be completely abolished in the elderly.…”

Section: Discussionsupporting

confidence: 63%

TSH enhancement of FT4 to FT3 conversion is age dependent

Strich

Karavani

Edri

et al. 2016

European Journal of Endocrinology

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Objective: We previously reported increasing free T3 (FT3) to free T4 (FT4) ratios as thyroid-stimulating hormone (TSH) increases within the normal range in children. It is not known if this phenomenon is age-related among humans, as previously reported in rats. This study examines the relationships between TSH and FT3/FT4 ratios in different ages. Design: Retrospective examination of thyroid tests from patients without thyroid disease from community clinics. Methods: Free T3, free T4, and TSH levels from 527 564 sera collected from patients aged 1 year or greater were studied. Exclusion criteria were the following: missing data, TSH greater than 7.5 mIU/L, and medications that may interfere with thyroid hormone activity. A total of 27 940 samples remaining after exclusion were stratified by age. Samples with available anthropometric data were additionally stratified for body mass index (BMI). Correlations of TSH to FT4, FT3, and FT3/FT4 ratios by age group were examined. Results: Up to age 40, for each increasing TSH quartile, FT3 and the FT3/FT4 ratio increased and FT4 decreased significantly (for both FT3, FT4 and FT3/FT4 ratio, P < 0.05 for every TSH quartile when compared with the 1st quartile, except FT3 in the 30-40 age group). In older age groups, increasing TSH was not associated with increased FT3/FT4 ratio. Conclusion: As TSH levels increase, FT3/FT4 ratios increase until age 40, but this differential increase does not occur in older age groups. This may reflect a decrease in thyroxine (T4) to triiodothyronine (T3) conversion with age, which may be part of the aging process.

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Section: Discussionsupporting

confidence: 63%

TSH enhancement of FT4 to FT3 conversion is age dependent

Strich

Karavani

Edri

et al. 2016

European Journal of Endocrinology

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“…The study subjects were categorized as euthyroid, subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism, and overt hyperthyroidism [7,10] ; the values of TSH are mentioned in Table 1.…”

Section: Methodsmentioning

confidence: 99%

A hospital-based study of prevalence of thyroid dysfunction in Srinagar, Jammu and Kashmir state of India

Jailkhani¹,

Ramachandrayya²,

Patil³

et al. 2015

Int J Med Sci Public Health

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“…Marwaha ve arkadaşlarının Hindistan'da yapılmış iki ça-lışmasında beş ile onaltı yaş arası çocuklarda TSH'nın ortalama değeri 3,17 mIU/L, 97 persentil değeri 7,5 mIU/L ölçüldüğü belirtilmiştir [11][12].…”

Section: şEkil 1 çOcuklarda Hipotiroidizmin Durumuunclassified

“…Genel olarak yayınlarda ise çocuklarda %2 erişkinlerde ise %1-10 arasın-da tespit edilmiştir [4,13,16]. Hindistan'da Marwaha'nın 39961 çocuk ile yaptığı çalışmada %6,1 SH tespit edilmiş-tir [12]. Lazar ve ark.…”

Section: Epidemiyolojiunclassified

Insidious danger in childhood era's: subclinical hypothyroidism

2017

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Insidious danger in childhood era's; subclinical hypothyroidism erleme d Öz Tiroid hormonları; santral sinir sistemi gelişimi, büyüme, gelişme, vücut ısısı regülasyonu, lipit, karbonhidrat ve enerji metabolizması, iskelet sistemi üzerinde önemli role sahiptir. Diğer yönden çocukluk çağında santral sinir sistemi myelinizasyonunda görevli olduğu için önemi farklıdır. Subklinik hipotiroidi, serum tiroid stimulan hormon seviyesinin orta düzeyde artması ile birlikte serum tiroid hormon seviyelerinin normal referans laboratuvar aralı-ğında olmasıdır. Çocuklarda %2 oranında görülmektedir. Etiyolojisinin büyük bir kısmını otoimmün tiroidit ve iyot eksikliği oluşturmaktadır. Asemptomatik olguların zamanında tanımlanması ve tedavisi önemlidir. Olgularda guatr, büyüme-gelişme geriliği veya duraksaması, ders başarısında azalma, negativizm, depresyon, obezite, demir eksikliği anemisi, dislipidemi, kemik yaşı geriliğinde levotiroksin tedavisi başlanması uygundur. Anahtar sözcükler: Çocukluk çağı, subklinik hipotiroidizm AbstractThyroid hormones have an important role on the central nervous system, growth, development, body temperature regulation, metabolism of lipid, carbohydrate and energy, musculoskeletal system. The other hand, it has a different importance for its role in the myelinization of the central nervous system during the childhood period. Subclinical hypothyroidism (SH), is diagnosed when peripheral thyroid hormone levels are within normal reference laboratory range but serum thyroid-stimulating hormone levels are mildly elevated. Prevalance of subclinical hypothyroidism in chilhood is seen about %2. The majority of its etiology is due to the autoimmune thyroiditis and iodine deficiency. It is important to diagnose and treat the asymptomatic cases in a timely manner. Thyroxin treatment should be started if goiter, growth velocity is slowed down, decline in school success, negativism, depression, obesity, refractory iron deficiency anemia dyslipidemia, bone age retardation.

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Reference range of thyroid hormones in normal Indian school‐age children

Abstract: This study provides mean reference intervals for FT3, FT4 and TSH for each year of life for both the sexes separately using strict exclusion criteria.

Cited by 28 publications

References 28 publications

TSH enhancement of FT4 to FT3 conversion is age dependent

TSH enhancement of FT4 to FT3 conversion is age dependent

A hospital-based study of prevalence of thyroid dysfunction in Srinagar, Jammu and Kashmir state of India

Insidious danger in childhood era's: subclinical hypothyroidism

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