Reference Values for Cord Blood Lipid and Lipoprotein Concentrations

Dyerberg, Jørn; Hjörne, N.; Nymand, Gunnar; Olsen, Jørgen

doi:10.1111/j.1651-2227.1974.tb04823.x

Cited by 11 publications

(9 citation statements)

References 20 publications

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“…This study confirms earlier observations in term newborn infants that alfa-lipoprotein levels represent about 50% or more of the total lipoproteins (1,6,13). The HDL concentration in term newborn infants was found to be 73.6+3.9% of the adult value (S.E.)…”

Section: Discussionsupporting

confidence: 92%

High Density Lipoprotein Concentrations in Newborn Infants

Ginsburg

Zetterström

1977

Acta Paediatrica

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The lipoprotein pattern was analyzed by agarose gel electrophoresis in 19 new born infants of varying gestational age. The HDL concentration was determined by rocket immunoelectrophoresis in another 41 newborn infants. Infants with a gestational age of less than 33 weeks had very low HDL concentrations compared to preterm infants with a gestational age of less than or equal to 33 weeks and term ihfants. In the first 5-10 days after birth the HDL concentration increased markedly in preterm infants (gestational age less than 37 weeks) whereas it remained unchanged in term infants.

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Section: Discussionsupporting

confidence: 92%

High Density Lipoprotein Concentrations in Newborn Infants

Ginsburg

Zetterström

1977

Acta Paediatrica

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“…Only 0.5% of the samples had both elevated cholesterol and TG. These cholesterol and TG distributions are similar to those previously reported (5,7,10,(28)(29)(30)(31)(32)(33)(34).…”

Section: Resultssupporting

confidence: 78%

High-Density Lipoprotein Subclass Distribution And Human Cord Blood Lipid Levels

1986

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ABSTRACT. The high-density lipoprotein (HDL) subclass distribution was examined by gradient gel electrophoresis (gge) in 154 human cord blood samples, and determinations of triglyceride, total cholesterol, and HDL-cholesterol levels were performed. Three distinct gge patterns were recognizable. The first pattern, termed the normal (gge) pattern, was distinguished by a prominent double peak in the (HDL2,),, region and a pronounced peak in the (HDL3b)gge region. Minor peaks, or shoulders, were also seen in the (HDLZb)gge and (HDL3Jae regions, and a valley was present in the (HDL3,),,, region. This pattern was associated with normal lipid levels for cord blood plasma (mean triglycerides: 30-42 mg/dl; mean total cholesterol 62-85 mg/dl; mean HDL-cholesterol: 34-41 mg/ dl).The second pattern, termed the 2b(gge) pattern, contained a major peak in the ( H D L z~)~~, region rather than the shoulder seen in the normal (gge) pattern, while the (HDL2.)gge, (HDL3b),e, and (HDL3,),, regions were less pronounced. This pattern was associated with elevated total cholesterol and HDL-C levels (means 85-102 and 49-56 mg/dl, respectively). The third pattern, termed the 3b(gge) pattern, was characterized by a paucity of material in the (HDL2,,),, region, a single peak in the (HDLza),, region, and either a relative increase in the (HDL3b),e region, or a simultaneous increase in both (HDLs~),~ and (HDL3e),e. This pattern was associated with elevated triglyceride levels (means 78-88 mg/dl) and decreased HDL-C levels (means 20-30 mg/dl). Only two infants had a simultaneous elevation of triglycerides and total cholesterol and both cases exhibited the 3b(gge) pattern. Our study demonstrates that although the triglyceride and cholesterol levels in the newborn are much lower than those in adults, they are the important factors associated with the HDL subclass distribution. Elevated cholesterol was related to increased particles in the (HDL2b), region while elevated triglyceride levels were associated with a decrease in (HDL2b+2a)gge particles and a concomitant increase in (HDLsb),, particles. (Pediatr Res 20: 487-491, 1986) Abbreviations HDL, high-density lipoproteins TG, triglyceride TC, total cholesterol HDL-C, HDL-cholesterol gge, gradient gel electrophoresis CB, cord blood Received October 7, 1985: accepted January 23, 1986. Address correspondence and requests for reprints to Orsolya Genzel-Boroviczeny, M.D., Donner Laboratory, 1-213, University of California, Berkeley, CA 94720.This work was supported by NIH Program Project Grant HL 18574 from the National Heart, Lung, and Blood Institute of the National Institutes of Health and NIH National Research Service Award Training Grant HL 07279.There is growing evidence that HDL, and in particular the HDL2 subclass, have a protective role in the process of atherogenesis (1-3). In contrast to adults, in whom low density lipoproteins predominate, HDL is the predominant lipoprotein species in human CB (4-10). Davis et al. (4) found that in healthy term infants with lipoprotein levels below 10...

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“…Cord blood lipoprotein levels have not been studied extensively but their characterization is obviously important. In the Bogalusa newborns, the mean values of P-, pre-p, and a-lipoprotein-cholesterol were 30 mg/dl, 4 mg/dl, and 36 mg/dl, respectively, which compare closely with other reported values (10,(12)(13)(14)21). Our observation that the average level of total cholesterol at birth is higher in whites than in blacks is opposite that reported in school-aged children (I 1, 22).…”

Section: Discussionsupporting

confidence: 79%

Serum Lipids and Lipoproteins at Birth in a Biracial Population: The Bogalusa Heart Study

Frerichs¹,

Srinivasan

Webber

et al. 1978

Pediatr Res

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SummaryThe lipid profile, total cholesterol, triglycerides, and lipoproteins (P-, pre-/I-, and a-) of cord blood, is presented for 419 black and ~h i t e infants (9.1% of the eligible population) born during an 18-month period in Bogalusa, Louisiana. At birth, white neonates of both seses had higher average levels than black neonates of total cholesterol and /I-lipoproteins. White girls among the four races e s groups had the highest cord blood levels of total cholesterol, /I-lipoproteins, and a-lipoproteins. Neither stress at delivery. birthweight, socioeconomic status, nor season of the year had an observable effect on any of the lipid or lipoprotein levels. The magnitude and direction-of the relationships between the respective lipids and lipoproteins in cord blood were similar to those we have observed in preschool and school-aged children in the same community. Total cholesterol was highly correlated with both /Iand a-lipoproteins; triglycerides were correlated with pre-/I-lipoproteins but inversely with a-lipoproteins. These observations suggest that basic biochemical relationships are already established at birth.

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Reference Values for Cord Blood Lipid and Lipoprotein Concentrations

Cited by 11 publications

References 20 publications

High Density Lipoprotein Concentrations in Newborn Infants

High Density Lipoprotein Concentrations in Newborn Infants

High-Density Lipoprotein Subclass Distribution And Human Cord Blood Lipid Levels

Serum Lipids and Lipoproteins at Birth in a Biracial Population: The Bogalusa Heart Study

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