Reference values for echocardiographic measurements of healthy newborns

Güzeltaş, Alper; Eroğlu, Ayşe Güler

doi:10.1017/s1047951111001259

Cited by 16 publications

(22 citation statements)

References 18 publications

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“…Using previously published normal values, z -scores were calculated 11,12. Mitral and aortic regurgitation were classified according to width and length of colour Doppler jet as mild (jet < 25%), moderate (jet 25–50%) or severe (jet > 50%).…”

Section: Methodsmentioning

confidence: 99%

Neonatal circulatory failure due to acute hypertensive crisis : clinical and echocardiographic clues : cardiovascular topics

Louw

Brown²,

Thewissen³

et al. 2013

CVJA

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ObjectiveCirculatory failure due to acute arterial hypertension in the neonatal period is rare. This study was undertaken to assess the clinical and echocardiographic manifestations of circulatory failure resulting from acute neonatal hypertensive crisis.MethodsNeonatal and cardiology databases from 2007 to 2010 were reviewed. An established diagnosis of circulatory failure due to neonatal hypertension before the age of 14 days was required for inclusion. Six patients were identified.ResultsFive patients presented with circulatory failure due to an acute hypertensive crisis. The median age at presentation was 8.5 days (range: 6.0–11.0) with a median body weight of 3.58 kg (range: 0.86–4.70). Echocardiography demonstrated mild left ventricular dysfunction [median shortening fraction (SF) 25%, range 10–30) and mild aortic regurgitation in 83% (5/6) of patients. One patient with left ventricular dysfunction (SF = 17%) had a large apical thrombus. Two patients were hypotensive, and hypertension only became evident after restoration of cardiac output. Administration of intravenous milrinone was successful, with rapid improvement of the clinical condition. Left ventricular function normalised in all survivors.ConclusionEarly neonatal circulatory collapse due to arterial hypertension is a rare but potentially life-threatening condition. At presentation, hypotension, especially in the presence of a dysfunctional left ventricle, does not exclude a hypertensive crisis being the cause of circulatory failure. The echocardiographic presence of mild aortic regurgitation combined with left ventricular hypocontractility in a structurally normal heart should alert the physician to the presence of underlying hypertension.

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Section: Methodsmentioning

confidence: 99%

Neonatal circulatory failure due to acute hypertensive crisis : clinical and echocardiographic clues : cardiovascular topics

Louw

Brown²,

Thewissen³

et al. 2013

CVJA

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“…Machine integrated ECG recording was performed simultaneously. Each measurement was taken three times and averaged [6].…”

Section: Echocardiographymentioning

confidence: 99%

“…The echocardiography was performed on the subject in supine position in his/her respective bassinet [6,11]. No sedation was used although a pacifier nipple was sometimes required to keep the neonate quiet and at rest [6,11].…”

Section: Echocardiographymentioning

confidence: 99%

“…The concept of "neonatologistperformed echocardiography" (NPE) has developed for improved cardiorespiratory care of newborn [5]. Several small studies have suggested normative data related to cardiac chambers in infants and newborn over last 50 years but none has been reported from the Indian subcontinent and no clear guidelines exist unlike adults [6]. A prior study by Mukherjee et al showed that echocardiographic chamber dimensions among normal Indian subjects not only varied from the western data but also varied among different parts of the country [7].…”

Section: Introductionmentioning

confidence: 99%

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A study on normal reference values of echocardiographic chamber dimensions in new born infants from eastern India- a pilot study

Halder¹,

S²,

Mukherjee³

et al. 2021

Preprint

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Introduction: Echocardiography has been an integral part of neonatal care since the 1990s and application of this technology is increasing ever since. It is already known that differences in weight, age and race significantly affect the normal heart dimensions. Therefore, establishing the normative values for cardiac dimensions among Indian healthy newborn infants is of paramount importance. In this study we report the normal reference values of echocardiographic chamber dimensions of newborn infants from eastern India. Methods: 100 healthy newborn infants were included in this cross-sectional, observational, single hospital-based pilot study. A single experienced cardiologist performed the trans-thoracic echocardiographic studies on the subjects in supine position in their respective bassinets. No sedation was used. The parameters were distributed according to body weight and in percentiles. Results: Subjects were categorized according to their body weight into three groups: 2-2.4 kg, 2.5-2.9 kg and 3-3.5 kg. Each group comprises of 7, 50 and 43 newborns respectively. Left ventricular end-diastolic dimension and left ventricular end-systolic dimension showed incremental trends across body weight. Conclusion: This study shows the difference of cardiac dimensions in Indian newborn infants from western data. This is the first study presenting the normative reference ranges and percentiles of echocardiographic parameters in Indian newborn infants which needs confirmation with larger multicenter studies.

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“…The first laboratory findings were as follows: creatine kinase (CK) >5,000 IU/L (normal: 60-305 IU/L), aspartate aminotransferase (AST) of 117 IU/L (normal: 7-40 IU/L), alanine aminotransferase (ALT) of 66 IU/L (normal: 7-35 IU/L), and lactate dehydrogenase (LDH) of 558 IU/L (normal: 150-450 IU/L). At day of life (DOL) 2, the patient was still on mechanical ventilation due to severe respiratory distress and muscular hypotonia, and grade 3 8 . Heart cavities were hypoplastic secondary to hypertrophy.…”

Section: Case Reportmentioning

confidence: 99%

A Newborn with Infantile-Onset Pompe Disease Improving after Administration of Enzyme Replacement Therapy: Case Report

Bor

İlhan

Gümüş

et al. 2020

J Pediatr Intensive Care

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Pompe disease (PD) is an autosomal recessive lysosomal storage disorder caused by a deficiency of acid α-1,4-glucosidase enzyme (GAA). PD has two forms, namely the infantile-onset and the late-onset form. In untreated cases, infantile-onset form usually leads to cardio-respiratory failure and death in the first year of life. Herein, we report a newborn with infantile-onset PD characterized by muscular hypotonia, respiratory distress, hypertrophic cardiomyopathy, hepatomegaly, elevated serum enzyme levels of aspartate aminotransferase of 117 IU/L (three times the normal value), alanine aminotransferase of 66 IU/L (1.8 times the normal value), lactate dehydrogenase of 558 IU/L (1.2 times the normal value), and creatine kinase >5,000 IU/L (16 times the normal value). Dried blood spot testing was performed and revealed decreased GAA enzymatic activity (0.07 nmol/mL/h, normal 0.93–7.33 nmol/mL/h). GAA gene analysis performed for confirming the diagnosis showed homozygous mutation c.896T >C (p.Leu299Pro). Initiation of enzyme replacement therapy (ERT) (ERT; 20 mg/kg, once every week) at 28 days of age resulted in weaning off from respiratory support within 1 week after treatment, normalization of cardiac abnormalities, and normal neuromotor development in the 16th month of age. Early diagnosis and early treatment with ERT, especially in the neonatal period, is of great importance to improve cardiac function and motor development in infantile-onset PD.

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Reference values for echocardiographic measurements of healthy newborns

Abstract: In this study, normative values related to body weight for cardiac chambers and wall thickness were determined in healthy newborns. These reference values can be used to evaluate whether newborns have normal or abnormal echocardiographic measurement.

Cited by 16 publications

References 18 publications

Neonatal circulatory failure due to acute hypertensive crisis : clinical and echocardiographic clues : cardiovascular topics

Neonatal circulatory failure due to acute hypertensive crisis : clinical and echocardiographic clues : cardiovascular topics

A study on normal reference values of echocardiographic chamber dimensions in new born infants from eastern India- a pilot study

A Newborn with Infantile-Onset Pompe Disease Improving after Administration of Enzyme Replacement Therapy: Case Report

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