Reference values of hemostasis related factors of healthy Japanese adults II. protein C

Tahara, Chieko; Kazama, Mutsuyoshi; Miyajima, Yukari; Matsumoto, Kenji; Abe, Takeshi

doi:10.1016/0049-3848(91)90154-o

Cited by 2 publications

(4 citation statements)

References 12 publications

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“…Furthermore in females there is a sharp rise in PC activity in the late 40's which on closer examination appears related to the menopause. This phenomenon was also noted by Thhara et al (11) however it was more evident for PC activity than PC antigen. Examination of PC antigen and activity in a small group of our donors did, however, show apparently parallel changes related to age in both males and females, It seems unlikely that differences in smoking habit could explain these age and sex related changes since within each subpopulation of the cohort there is no significant effect of smoking on PC activity.…”

Section: Influence Of Smokingsupporting

confidence: 79%

“…). Within the adult population initial reports from relatively small numbers of healthy subjects (often less than 100) suggested there were no significant differences in PC activity or antigen levels related to age or sex (LZ,22-24).More recently however, Miletich et al(9), examining 683 blood donors, identified a 4"/" per decade rise in mean PC antigen level.Thhara et al(11), in a study of 540 Japanese, found similar age related variation in both activity and antigen measurements, particularly in females, as well as minor differences between the sexes. Also, in an interim analysis of 2,341 male donors in the present study, w€ demonstrated considerable variation in mean PC activity related to age, particularly in young males through the significant differences in mean PC between males and females of similar age are indicated * p <0.01, ** p <0.001., *** p <0.0001 and between consecutive age bands .…”

mentioning

confidence: 67%

“…There is a general pattern of lower PC in pre-menopausal females and higher PC in post-menopausal females compared to males of the same age. These relationships were evident in the Japanese study (11) but could be easily overlooked if age-restricted analyses are not undertaken.…”

Section: Influence Of Smokingmentioning

confidence: 91%

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Protein C Activity in Healthy Volunteers - Influence of Age, Sex, Smoking and Oral Contraceptives

et al. 1993

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SummaryInterpretation of protein C (PC) levels in a given individual has several limitations. A normal PC activity does not necessarily exclude a genetic deficiency nor can a reduced level confirm it. Measuring PC amidolytic activity in 9,648 healthy blood donors has allowed identification of demographic factors which cause variation in PC activity and further hinder interpretation. PC activity displays a log normal distribution and significant variation with age. This is most marked in young adult males when mean PC activity rises from 0.86 iu/ml (15–19 years) to 1.04 iu/ml (45–49 years; P <0.0001). Pre-menopausal females, who for most age ranges, have mean PC activity below their male contemporaries, show a less marked rise with age until the menopause when PC activity rises further. The use of hormonal contraceptive preparations is associated with an increase in mean PC activity of 0.05–0.08 iu/ml while smoking habit has no influence on PC activity.In view of these findings we strongly recommend the use of age and sex restricted reference ranges when interpreting PC activity.

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Section: Influence Of Smokingsupporting

confidence: 79%

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confidence: 67%

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Protein C Activity in Healthy Volunteers - Influence of Age, Sex, Smoking and Oral Contraceptives

et al. 1993

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“…Changes in the anticoagulant proteins occurring in the elderly has been a topic in the literature since 1977 [113]. Both levels and activity of antithrombin III (ATIII) and protein C (PC) have been under investigation over the years with varying results [67,70,71,96,[114][115][116][117][118][119], which are summarized in Tables 1 and 2, respectively. In more detail, Hager et al noted a decrease in ATIII levels in the elderly [71].…”

Section: Coagulation Factors With Anticoagulant Propertiesmentioning

confidence: 99%

Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update

et al. 2022

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The aim of this review is to highlight all the factors that associate venous thromboembolism (VTE) with aging. Elderly people are characterized by a higher incidence of thrombosis taking into account the co-existing comorbidities, complications and fatality that arise. Based on the Virchow triad, pathophysiological aspects of venous stasis, endothelium injury and hypercoagulability in elderly people (≥65 years) are described in detail. More precisely, venous wall structure, nitric oxide (NO) and endothelin-1 expression are impaired in this age group. Furthermore, an increase in high-molecular-weight kininogen (HMWK), prekallikrein, factors V, VII, VIII, IX and XI, clot lysis time (CLT) and von Willebrand factor (vWF) is observed. Age-dependent platelet dysfunction and changes in anticoagulant factors are also illustrated. A “low-grade inflammation stage” is delineated as a possible risk factor for thrombosis in the elderly. Consequently, clinical implications for frail elderly people related to diagnosis, treatment, bleeding danger and VTE recurrence emerge. We conclude that aging is an acquired thrombotic factor closely related to pathophysiological changes.

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Reference values of hemostasis related factors of healthy Japanese adults II. protein C

Cited by 2 publications

References 12 publications

Protein C Activity in Healthy Volunteers - Influence of Age, Sex, Smoking and Oral Contraceptives

Protein C Activity in Healthy Volunteers - Influence of Age, Sex, Smoking and Oral Contraceptives

Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update

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