Reference values of IGF-I in children from birth to 5 years of age, in Burkina Faso, using blood samples on filter paper

Kouanda, Séni; Tonglet, René; Coninck, Virginie de; Doulougou, Boukaré; Sondo, Blaise; Ketelslegers, J. M.; Robert, Annie

doi:10.1016/j.ghir.2008.01.008

Cited by 12 publications

(14 citation statements)

References 17 publications

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“…For children older than 2 years, a stadiometer was used. Nutritional status, expressed as weight for height (WHZ) and height for age (HAZ), was standardised for age and sex using either the reference tables from the Burkina Faso reference tables [25] or the United States National Center for Health Statistics (NCHS) [26, 27]. The reference tables of Burkinabe children were constructed from anthropometric measures collected during the survey on the reference values of IGF-I in Burkina Faso [25].…”

Section: Methodsmentioning

confidence: 99%

“…We validated the methods of determining the IGF-I levels from dried blood spots on filter paper on IGF-I RIA, after separating the IGF-I from its binding proteins using Sep-Pack chromatography [25]. …”

Section: Methodsmentioning

confidence: 99%

“…The concentration of the standard curve spans over a range of 0.05 to 2 ng/mL. Intra-assay and total imprecision of the RIA were of 5% and 16% at a level of 0,25 ng/mL and of 5% and 22% at a level of 1.01 ng/mL [25]. …”

Section: Methodsmentioning

confidence: 99%

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Insulin Growth Factor-I in Protein-Energy Malnutrition during Rehabilitation in Two Nutritional Rehabilitation Centres in Burkina Faso

Kouanda

Doulougou

Coninck³

et al. 2009

Journal of Tropical Medicine

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Objective. To investigate the relationship between IGF-I and the nutritional status of West-African children hospitalised for nutritional rehabilitation. Patients and methods. A cohort study was performed in two centres for nutritional rehabilitation and education (CREN) in Burkina Faso. Children were followed and the anthropometric data as well as the capillary blood samples were taken on the 7th and on the 14th days after their admission. IGF-I levels were determined from dried blood spots on filter paper on IGF-I RIA, after separation of the IGF-I from its binding proteins, using Sep-Pak chromatography. Results. A total of 59 children was included in the cohort. The IGF-I mean geometric values (SD) were 6.3 (1.4) μg/L on admission, 8.6 (1.8) μg/L at day 7 and 13.6 (2.0) μg/L at day 14. The differences between these values were statistically significant (P < .001). There is a significant correlation between the changes of IGF-I with the change of weight for height Z-score (P = .01). Conclusion. These results suggest that IGF-I can be considered as a potential marker to follow the nutritional status of children admitted in hospital for protein and energy malnutrition.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Insulin Growth Factor-I in Protein-Energy Malnutrition during Rehabilitation in Two Nutritional Rehabilitation Centres in Burkina Faso

Kouanda

Doulougou

Coninck³

et al. 2009

Journal of Tropical Medicine

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“…Immulite IGF-I and IGFBP-3 assays IGF-I was stable in EDTA tubes, but increased in serum and LiH tubes by $15% after 24 h, and by $40% at end of study. IGFBP-3 levels fluctuated more in all three media, but were fairly stable in EDTA and LiH tubes for up to 7 days Kouanda et al [70] 11 infants Blood samples collected on filter paper for 1-2 weeks at 5°C or at RT were compared to serum stored at À20°C…”

Section: The Requirements For Generating Igf-i Reference Rangesmentioning

confidence: 99%

The current status of IGF-I assays – A 2009 update

Frystyk

Freda

Clemmons

2010

Growth Hormone & IGF Research

178

129

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For almost three decades, the measurement of circulating IGF-I has constituted a highly important biochemical tool in the management of GH disorders. In fact, in acromegaly the importance of circulating IGF-I has increased following the introduction of the GH receptor antagonist pegvisomant, as the use of this drug makes it impossible to use circulating GH as a monitor of disease activity. In addition, determination of circulating IGF-I constitutes a valuable scientific tool in various research areas, from epidemiological investigations through clinical trials and experimental studies. The multiple facets of IGF-I physiology and patho-physiology may explain why numerous endocrine laboratories have invested in IGF-I assays, by means of either in-house assays or commercial kits. However, despite its widespread use, the measurement of IGF-I is by no means trivial. On the contrary, the pronounced binding of IGF-I to the high-affinity IGF-binding proteins (IGFBPs) constitutes a notorious source of error, which has necessitated the development of methods that more or less successfully circumvent interference from the IGFBPs. Furthermore, there are some unsolved issues with the international standardization of the different IGF-I assays and there is no consensus regarding the procedures used when collecting and storing samples for measurement of circulating IGF-I. The aim of this review is to discuss the current state of the art of IGF-I immunoassays and to present the current analytical problems with IGF-I measurements. Finally, we would like to suggest an agenda that may be used when trying to produce internationally accepted uniform requirements for future IGF-I assays.

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“…In addition, the development of reliable reference intervals for IGF1 is a significant challenge since it concentration is sex-specific and varies widely with age. Circulating mean IGF1 levels increase relatively slowly in childhood but as much as a fivefold increase can be observed across Tanner stages and deceases steadily to pre-pubertal levels in aged population [30,31]. Typically age specific z-scores are reported to address the wide variability of IGF1 with age and Tanner stage.…”

Section: Physiological and Analytical Considerations For Igf1 Assaysmentioning

confidence: 99%

Clinical assays for quantitation of insulin-like-growth-factor-1 (IGF1)

Ketha

Singh

2015

Methods

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Reference values of IGF-I in children from birth to 5 years of age, in Burkina Faso, using blood samples on filter paper

Cited by 12 publications

References 17 publications

Insulin Growth Factor-I in Protein-Energy Malnutrition during Rehabilitation in Two Nutritional Rehabilitation Centres in Burkina Faso

Insulin Growth Factor-I in Protein-Energy Malnutrition during Rehabilitation in Two Nutritional Rehabilitation Centres in Burkina Faso

The current status of IGF-I assays – A 2009 update

Clinical assays for quantitation of insulin-like-growth-factor-1 (IGF1)

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