Reference values of impulse oscillometry (IOS) for healthy Chinese children aged 4-17 years

Abstract

Objective: To establish the predicted value of pulmonary function determined by Impulse Oscillometry (IOS) in children (4~17 years old) in China. Methods: A total of 6270 healthy children aged 4 to 17 in Shanghai were included. The Master Screen IOS pulmonary function device (Jaeger Co, Germany) was used to detect the respiratory impedance (Zrs), resonant frequency (Fres)), viscosity resistance (Rrs) and elastic resistance (Xrs) at various oscillation frequencies, and the indexes above were analyzed. The stepwise multivariate regression was used to establish the regression equation of related parameters of IOS in different genders, ages, height, and weight. Results: The differences in the main IOS parameters between different age groups are statistically significant regardless of sex (P<0.05). The stepwise multivariate regression analysis showed that IOS parameters were related to height, age, and weight, and most IOS parameters were most closely related to height (the absolute value of regression coefficient was the largest). With the increase of age and height, the values of Z5, R5, R20 and Fres decreased, while the value of X5 increased. Through height, age and weight, we get the normal predicted values equation of children's IOS parameters. Compared with lechtenboerger prediction equation, our equation is more suitable for Chinese children.Conclusions: The study revealed the reference values of IOS parameters in healthy Chinese children. In the evaluation of results for lung function measurements, this predicted value equation is more in line with the characteristics of Chinese children than that of foreign's.Clinical Trial：ChiCTR: 1800019029.