Reference values of osteocalcin and procollagen type I N-propeptide plasma levels in a healthy Central European population aged 0–18 years

Abstract

This study provides reference data for OC and PINP in healthy Caucasian children from a Central European population.

Serum undercarboxylated osteocalcin correlates with hemoglobin A1c in children with recently diagnosed pediatric diabetes

“…This observation is consistent with the known favorable effect of OC on insulin secretion and sensitivity, which are both impaired in T2D, while only the former is abnormal in most cases of T1D. The differences between males and females may be related to sex hormone levels, which have been reported to influence OC metabolism in healthy children and adults …”

“…The differences between males and females may be related to sex hormone levels, which have been reported to influence OC metabolism in healthy children and adults. [30][31][32][33] Several clinical reports have shown that higher total OC levels are associated with better glucose homeostasis. 5,[8][9][10][11][12] Pediatric studies have been conflicting, with some reports that serum OC is inversely associated with the presence of established T2D and inversely correlated with HbA1c 13 while others found an inverse association between total OC and HbA1c as well glucose parameters in adults but not in children.…”

Effect of age and sex on bone markers in Chlorocebus aethiops raised in captivity

“…In the present study, we observed a decline in terms of age at concentrations of formation markers (PINP; OC) and bone resorption (β‐CTX). These results are similar to studies carried out in humans, where concentrations of PINP , β‐CTX , and OC were measured in rhesus monkeys . These age‐related changes in markers most likely were observed due to the physiological evolution between the end of the process of growth and the bone remodeling that occurs with the development of adults .…”

Ontogenetic changes to bone microstructure in an archaeologically derived sample of human ribs

“…Similarly, Schnitzler & Mesquista () found that drifting osteons with large active canals accounted for over 70% of childhood cortical porosity in biopsies of the iliac crest. The inverse correlation between Po.Dn and age likely reflects a decrease in the remodeling rate after infancy (Szulc et al ; Bayer, ). Ct.Po appears to demonstrate a non‐linear relationship with age.…”