Reference Values of Serum Cystatin-C for Full-Term and Preterm Neonates in Istanbul

Dorum, Sevil; Şehitoğlu, İbrahim; Dorum, Bayram Ali̇; Şilfeler, Dilek Benk; Canbak, Yekta; Say, Aysu

doi:10.1007/s12098-011-0655-y

Cited by 22 publications

(22 citation statements)

References 19 publications

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“… used the PENIA method in 100 normal term neonates and also measured higher values of cysC in cord blood (median 2.02 mg/L; range 1.54 to 2.64), which are close to our preliminarily published results . Somewhat lower values than ours were reported by Dorum (1.21 ± 0.31 mg/L), who measured cysC values in cord blood in 33 normal term neonates taken just above the insertion point at which the umbilical cord attaches to the placenta, where the possibility of mixture with the mother's blood is higher.…”

Section: Discussionsupporting

confidence: 89%

Serum Cystatin‐C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia

Treiber¹,

Gorenjak

Balon

2013

Ther Apher Dial

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We evaluated cystatin-C (cysC) in the umbilical blood as a predictor of acute kidney injury (AKI) after perinatal hypoxia/asphyxia compared with creatinine (Cr). One hundred full-term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia/asphyxia [AS] and 50 controls). CysC and Cr were measured in blood samples from the umbilical cord at birth (cysC-umb and Cr-umb) and from a peripheral vein 3 days later (cysC-3 and Cr-3). At birth, the mean level of cysC in healthy term babies was found to be 1.39 ± 0.19 mg/L and 1.34 ± 0.21 mg/L after 3 days of life, not significantly decreased (P = 0.137). The mean of cysC in the AS group was 2.12 ± 0.53 mg/L in cord blood and 1.56 ± 0.32 g/L in day 3 blood samples, also decreased (P < 0.001) and different from the control (P < 0.001). Cr levels, determined simultaneously at birth were different (P = 0.001) between the control (62.74 ± 12.84 μmol/L) and AS (72.60 ± 15.55 μmol/L) group, significantly decreased after 3 days in both groups (P < 0.001). The receiver-operating characteristic curve analysis, comparing AS and the control group, showed area under the curve for cysC-umb, cysC-3, Cr-umb and Cr-3 (0.918; 0.698; 0.692; 0.660). The highest diagnostic accuracy was achieved with a chosen cut-off for cysC-umb of 1.67 mg/L (sensitivity of 84.0%, specificity of 90.0%) or 1.69 mg/L (sensitivity of 82.0%, specificity of 94.0%). Our results indicate serum CysC is a more sensitive marker of glomerular filtration rate than Cr in the newborns.

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Section: Discussionsupporting

confidence: 89%

Serum Cystatin‐C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia

Treiber¹,

Gorenjak

Balon

2013

Ther Apher Dial

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“…But in Dorum's research, 26 Cys-C values showed a downward trend as follows (P < 0.05): 1.41 AE 0.27 mg/L (28-33 weeks), 1.22 AE 0.30 mg/L (33-36 weeks) and 1.21 AE 0.31 mg/L (>37 weeks), respectively. But in Dorum's research, 26 Cys-C values showed a downward trend as follows (P < 0.05): 1.41 AE 0.27 mg/L (28-33 weeks), 1.22 AE 0.30 mg/L (33-36 weeks) and 1.21 AE 0.31 mg/L (>37 weeks), respectively.…”

Section: Discussionmentioning

confidence: 83%

Reference values for serum cystatin C in very low‐birthweight infants: From two centres of China

Yang

Pan

et al. 2017

J Paediatrics Child Health

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“…Even if we limit the analysis to blood samples in healthy term neonates in the first 24 h of life to restrict the impact of covariates, there is significant difference in mean values reported following PETIA [16,19,20] or ELISA [26] compared to PENIA assays [21,23,27,28,30], as illustrated in Figure 1. Finally, (iv) disease characteristics like respiratory distress [36], bilateral kidney abnormalities [25], peripartal asphyxia [30,38], aminoglycoside exposure [29], hemoglobin [30,38], renal dysfunction [33,37] or sepsis [39] also affect the CysC values observed, but not always in the expected direction.…”

Section: Discussion: How To Aim For a Moving Target?mentioning

confidence: 99%

“…In 5 of these cohorts, CysC measurement was based on PENIA [21,23,27,28,30], there was one ELISA measurement [26] and 3 PETIA [16,19,20] based measurements. Mean values following PENIA were significantly lower when compared to non-PENIA techniques [PENIA = particle enhanced nephelometric immune-assay; PETIA = particle enhanced turbimetric immune-assay; ELISA = enzyme linked immune-sorbent assay].…”

Section: Figurementioning

confidence: 99%

Cystatin C in newborns: a promising renal biomarker in search for standardization and validation

Allegaert

Mekahli

Anker

2014

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective Neonatologists still commonly use creatinine as a proxy for renal clearance, despite issues related to neonatal (patho)physiology and methodology (assay variability). Cystatin C (CysC) has been suggested to be a more reliable biomarker, but assay related differences have also been reported in children and adults. We are unaware of any review on the assay related impact on CysC reference values in newborns. Methods A structured literature search was performed on published CysC values in (pre)term neonates. Results The extensive range (>5-fold) in serum CysC observations in neonates in part relates to the fact that CysC concentrations are higher at birth with subsequent decrease and that CysC concentrations are higher in preterm compared to term neonates. The CysC assay matters while disease characteristics also affect CysC values, but not always in the predicted direction. Conclusions Similar to creatinine, the extensive CysC range in neonates is only in part explained by renal (patho)physiology. Its applicability in neonatal medicine can be further improved by use of assay specific reference values, adapted to neonatal renal physiology (e.g. weight, age) and should be compared to a gold standard such as inulin clearance.

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Reference Values of Serum Cystatin-C for Full-Term and Preterm Neonates in Istanbul

Abstract: Evaluation of cystatin C can be effective for follow-up of renal pathologies, because it is not affected by gender, body weight and muscle mass and has a constant production rate.

Cited by 22 publications

References 19 publications

Serum Cystatin‐C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia

Serum Cystatin‐C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia

Reference values for serum cystatin C in very low‐birthweight infants: From two centres of China

Cystatin C in newborns: a promising renal biomarker in search for standardization and validation

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