2023
DOI: 10.21203/rs.3.rs-2816213/v1
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Refined Protocol for Newly Onset Identification in Non-obese Diabetic Mice: An Animal-friendly, Cost-Effective, and Efficient Alternative

Abstract: Determining the onset of diabetes based on blood glucose (BG) levels can be challenging in mouse models, as thresholds can vary from 200 to 400 mg/dl in one or two consecutive tests. Urine glucose (UG) levels can be detected non-invasively as another criterion of diabetic condition, but it is considered a lagging indicator due to physiological downstream from BG. In this study, we demonstrate that the lagging period is practically unnoticeable in spontaneously model of non-obese diabetic (NOD) mice which devel… Show more

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