Reflectance Confocal Microscopy for Diagnosis of Mammary Paget’s Disease

Oliveira, António Gouveia; Zalaudek, Iris; Arzberger, Edith; Massone, Cesare; Hofmann‐Wellenhof, Rainer

doi:10.2340/00015555-2402

Cited by 6 publications

(11 citation statements)

References 13 publications

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“…In our case, hyporeflective Paget cells with abundant, pale cytoplasm and small, mildly bright nuclei within dense tumor nests or scattered as single cells observed on RCM were in accordance with the recent literature [ 3 , 4 , 8 ]. They were clearly different from the pagetoid cells of melanoma, which have bright cytoplasm and dark nucleus.…”

Section: Discussionsupporting

confidence: 93%

“…Cinnoti et al have also described the isolated Paget cells as hyper-reflective cells with a dark halo in a targetoid appearance at the superficial layers together with hyporeflective, roundish, large cells at the basal layer [ 5 ]. Oliveira et al have also described RCM findings of five cases of MPD, similar to the report by Guitera et al, as target structures and dark holes [ 8 ]. They reported that on RCM, Paget cells were seen as 1.5–2 times larger the keratinocytes and explained that these cells observed as dark holes were poorly reflective due to their abundant pale cytoplasm, and that the bright central area seen in target structures were related with their pleomorphic nuclei [ 8 ].…”

Section: Discussionsupporting

confidence: 77%

“…Oliveira et al have also described RCM findings of five cases of MPD, similar to the report by Guitera et al, as target structures and dark holes [ 8 ]. They reported that on RCM, Paget cells were seen as 1.5–2 times larger the keratinocytes and explained that these cells observed as dark holes were poorly reflective due to their abundant pale cytoplasm, and that the bright central area seen in target structures were related with their pleomorphic nuclei [ 8 ]. All the MPD cases are summarized in Table 1 .…”

Section: Discussionsupporting

confidence: 77%

“…RCM findings of Paget disease are limited in the literature [ 1 – 8 ]. Some of the reported cases are extramammary type [ 3 , 4 , 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some of the reported cases are extramammary type [ 3 , 4 , 6 , 7 ]. RCM findings of mammary Paget disease were reported in four articles [ 1 , 2 , 5 , 8 ] in total of eight cases. The first case reported by Longo et al was a 70-year-old woman with pigmented MPD.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Reflectance confocal microscopy of mammary Paget disease

Özdemir

Türk

Yaman

et al. 2017

Dermatol Pract Concept

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Mammary Paget disease is the intraepidermal adenocarcinoma of the nipple area which is characterized usually by a well-demarcated eczematous plaque. Reflectance confocal microscopy (RCM), is an in vivo noninvasive diagnostic tool with a high-resolution imaging of the skin, almost comparable to conventional histology. RCM findings of Paget disease are limited in the literature. Most of the reported cases are the extramammary type. In this report, we aimed to evaluate the RCM findings of a non-pigmented mammary Paget disease in a 65 year-old woman.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 77%

“…RCM findings of Paget disease are limited in the literature [ 1 – 8 ]. Some of the reported cases are extramammary type [ 3 , 4 , 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Reflectance confocal microscopy of mammary Paget disease

Özdemir

Türk

Yaman

et al. 2017

Dermatol Pract Concept

View full text Add to dashboard Cite

show abstract

Mammary Paget’s disease diagnosed with reflectance confocal microscopy

Yang

Wang

et al. 2020

Photodiagnosis and Photodynamic Therapy

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Nipple and areola lesions: review of dermoscopy and reflectance confocal microscopy features

Cinotti

Galluccio

Tognetti

et al. 2019

Acad Dermatol Venereol

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The differential diagnosis of nipple and areola complex (NAC) lesions encompasses a large spectrum of conditions from benign tumours to inflammatory diseases that could be challenging to recognize on clinical ground. While melanoma (MM) of the NAC is exceedingly rare, benign lesions are more frequent but could be difficult to distinguish from MM.Besides MM, other malignant tumours can affect this area and in particular Paget's disease (PD). For clinically doubtful lesions, biopsy is required, with possible functional and aesthetic consequences in this sensitive area. Dermoscopy and reflectance confocal microscopy (RCM) are widely used techniques for the diagnosis of many skin lesions, but their use for NAC lesions is not well established. The objective of this study was to evaluate current literature on these imaging techniques for NAC lesions. We searched in Medline, PubMed and Cochrane database all studies up to November 2018 dealing with dermoscopy, RCM and this special site. We found that the most described malignant tumour was PD and that only three primary MMs of the NAC have been reported with these imaging techniques. Although there are few data on diagnostic accuracy of non-invasive imaging techniques for NAC lesions, it seems that dermoscopy and RCM can add relevant information to be integrated with clinical examination for the diagnosis of NAC lesions and in particular for the differential diagnosis of PD and eczema.

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Reflectance Confocal Microscopy for Diagnosis of Mammary Paget’s Disease

Cited by 6 publications

References 13 publications

Reflectance confocal microscopy of mammary Paget disease

Reflectance confocal microscopy of mammary Paget disease

Mammary Paget’s disease diagnosed with reflectance confocal microscopy

Nipple and areola lesions: review of dermoscopy and reflectance confocal microscopy features

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