Reflectance confocal microscopy in paediatric patients: Applications and limits

Scharf, Camila; Brizzi, Eugenia Veronica Di; Licata, Gaetano; Piccolo, Vincenzo; Argenziano, Giuseppe; Moscarella, Elvira

doi:10.1111/exd.14691

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…19 The RCM can be considered as an alternative for a biopsy, with a resolution similar to one observed in the histopathological examination, therefore allowing to avoid unnecessary biopsies in children. 6,20 Alarcon et al 21…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Concurrently, the risk of melanoma in pediatric patients remains very low. [4][5][6] Therefore, a proper diagnostic process must be implemented to exclude potential atypia in the nevus, with care to minimize the rate of unnecessary, "prophylactic" surgical excisions.…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] RCM can provide insightful diagnostic information, allowing reduction of melanoma misdiagnosis and minimizing unnecessary surgical excisions. 6 Given the prevalence of melanocytic nevi in children, and psychological concerns of their caregivers when nevi evolve, it is important to improve the diagnostic process of these nevi.…”

Section: Introductionmentioning

confidence: 99%

“…While newly acquired nevi can appear during childhood, congenital nevi can continue to grow and clinically change, causing caregiver concern 2,3 . Concurrently, the risk of melanoma in pediatric patients remains very low 4–6 . Therefore, a proper diagnostic process must be implemented to exclude potential atypia in the nevus, with care to minimize the rate of unnecessary, “prophylactic” surgical excisions.…”

Section: Introductionmentioning

confidence: 99%

“…Reflectance confocal microscopy (RCM) in vivo is a modern, noninvasive diagnostic tool that has already been proven to be superior to dermoscopy in the diagnosis of various skin tumors 9–11 . RCM can provide insightful diagnostic information, allowing reduction of melanoma misdiagnosis and minimizing unnecessary surgical excisions 6 . Given the prevalence of melanocytic nevi in children, and psychological concerns of their caregivers when nevi evolve, it is important to improve the diagnostic process of these nevi.…”

Section: Introductionmentioning

confidence: 99%

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Application of dermoscopy and reflectance confocal microscopy in vivo in the evaluation of nevi in children

Pogorzelska‐Antkowiak,

Gonzalez

2024

Pediatric Dermatology

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BackgroundMelanocytic nevi are frequently observed in the pediatric population. While newly acquired nevi can appear during childhood, congenital nevi can continue to grow and clinically change, making patient caregivers concerned. Reflectance confocal microscopy (RCM) in vivo is a noninvasive tool that might enhance the diagnostic accuracy of dermoscopy, reducing the rate of unnecessary surgical procedures. This study aimed to assess the utility of RCM in increasing the diagnostic accuracy of pediatric melanocytic nevi that show pigmentation changes or grow rapidly.MethodsPediatric patients who presented between January 2022 and February 2023 in a single institution with rapidly growing melanocytic nevi or nevi that presented changes in the pigmentation were included in the study. All nevi were evaluated by means of dermoscopy and RCM.ResultsForty‐two patients with a total of 42 melanocytic nevi were included. Most lesions showed a honeycombed pattern (n = 21, 50%). On RCM, only 3 of 42 nevi presented atypical cells within the epidermis (7.1%). Evaluation of the dermoepidermal junction (DEJ) revealed the predominance of the meshwork pattern (n = 22, 52.4%). Notably, features considered significant for atypical melanocytic nevi included 9 nevi with scant atypical melanocytes (21.4%) and 3 nevi with nonedge papillae (7.1%). None of the studied lesions required biopsy among this cohort.ConclusionsMost rapidly growing and clinically changing nevi rarely exhibit single atypical cells in the DEJ. The RCM served as a valuable adjunct to dermoscopy, allowing reassurance in the evaluation of these lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Application of dermoscopy and reflectance confocal microscopy in vivo in the evaluation of nevi in children

Pogorzelska‐Antkowiak,

Gonzalez

2024

Pediatric Dermatology

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Eruptive Pseudoangiomatosis and Parvovirus: Exclusive Findings in Clinical Manifestation from a Report of Four Cases

Gaudiello,

Spennato,

Cillo

et al. 2024

International Journal of Dermatology and Venereology

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Introduction: Eruptive pseudoangiomatosis (EP) is a rare type of cutaneous exanthema characterized by red angioma-like papules. An association of EP with viral infection has been reported. We herein describe four pediatric patients who showed a new variant of EP-associated rash with atypical clinical features and positivity for parvovirus B19 infection. Case Report: Pediatric patients showed a new variant of EP-associated rash with atypical clinical features and positivity for parvovirus B19 infection by dermoscopy and reflectance confocal microscopy. The papules were localized to the face and characteristic perilesional halo was absent. In all patients, serology revealed evidence of active infection by parvovirus B19. Discussion: Few cases of a facial pseudoangiomatous rash that is related to parvovirus B19 infection and lacks the typical anemic halo have been reported in the literature. Conclusion: These cases provide new data on the clinical spectrum of EP and its association with parvovirus.

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Utility of line-field confocal optical coherence tomography in the pediatric population

Cappilli

Guerriero

IACOANGELI

et al. 2023

Ital J Dermatol Venereol

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Reflectance confocal microscopy in paediatric patients: Applications and limits

Abstract: Reflectance confocal microscopy (RCM) is a non-invasive diagnostic tool extensively studied for adult patients.

Cited by 4 publications

References 12 publications

Application of dermoscopy and reflectance confocal microscopy in vivo in the evaluation of nevi in children

Application of dermoscopy and reflectance confocal microscopy in vivo in the evaluation of nevi in children

Eruptive Pseudoangiomatosis and Parvovirus: Exclusive Findings in Clinical Manifestation from a Report of Four Cases

Utility of line-field confocal optical coherence tomography in the pediatric population

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