Reflectance confocal microscopy: non‐invasive distinction between actinic keratosis and squamous cell carcinoma

Abstract

This study revealed specific RCM features that can distinguish between AK and SCC, stimulating further prospective, large cohort research in this field. This will result in correct, efficient and adequate diagnosis and treatment of clinically difficult to distinguish AK and SCC lesions.

Through the looking glass: Basics and principles of reflectance confocal microscopy

“…36 While there is some overlap in the RCM features of SCCs and actinic keratoses, a disarranged epidermal pattern at the spinous-granular layer and the presence of neoplastic aggregates in the dermis are highly suggestive of SCC (Fig 9). 37 Notably, imaging of …”

On the horizon: Optical imaging for cutaneous squamous cell carcinoma

“…Contrast enhancement using dye (5% acetic acid) and cross‐polarization imaging has been proposed to address this challenge for nonmelanoma skin cancer . A recent study imaging 30 lesions in vivo (6 cutaneous SCCs, 24 actinic keratoses) demonstrated the utility of confocal microscopy to noninvasively distinguish between cutaneous SCC and actinic keratosis with 88.5% accuracy . However, poor interobserver agreement in all but the most experienced confocal microscopy operators was reported.…”

Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma

“…Atypical honeycomb/ a disarranged pattern 100% [40][41][42] Round nucleated cells at the spinous-Granular Layer 50-65% 40,41 Round vessels in the dermis 39-100% 40,41 Multiphoton tomography…”