“…3,4 Reflex testing for high-risk human papillomavirus (HPV) DNA in patients with ASCUS has been demonstrated to be highly sensitive for detecting cervical intraepithelial neoplasia (CIN) grade 3 (CIN 3), the precursor of cervical cancer, resulting in fewer women, both younger and older, being referred for colposcopy. 5,6 The overall sensitivity of HPV DNA testing at the 1.0 pg/mL level for detecting CIN 3 or cancer was reported to be 96.1% and varied minimally from 93.9% to 97.8% among women of different ages with an ASCUS interpretation. 5 The peak prevalence of HPV infection occurs in sexually active young women and decreases in middle-aged women.…”