Reflex sympathetic dystrophy associated with amyotrophic lateral sclerosis

Carvalho, Mamede de; Nogueira, António; Pinto, Anabela; Miguéns, José; Luís, M.L. Sales

doi:10.1016/s0022-510x(99)00220-8

Cited by 16 publications

(4 citation statements)

References 11 publications

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“…Different mechanisms for pain in ALS are reported, including muscle spasms, contractures and spasticity, abnormal stresses on the musculoskeletal system imposed by weak musculature, joint pain because of immobilization or articular blocks [2]. In a few cases, complex regional pain syndrome and reflex sympathetic dystrophy have been also described in ALS [23,24].…”

Section: Discussionmentioning

confidence: 99%

Pain in amyotrophic lateral sclerosis: a population‐based controlled study

Chiò

Canosa

Gallo

et al. 2011

Euro J of Neurology

104

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Section: Discussionmentioning

confidence: 99%

Pain in amyotrophic lateral sclerosis: a population‐based controlled study

Chiò

Canosa

Gallo

et al. 2011

Euro J of Neurology

104

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“…In fact, it could be interesting to defi ne what the possible metabolic mitochondrial derangements are within the subpopulation of hypermetabolic patients. Additionally, further study of sympathetic system activation might yield additional clues to potential autonomic dysregulation hypothesized to exist in ALS [35,36] .…”

Section: Discussionmentioning

confidence: 99%

Hypermetabolism in ALS: Correlations with Clinical and Paraclinical Parameters

Desport¹,

Torny²,

Lacoste³

et al. 2005

Neurodegener Dis

216

162

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Despite a reduction in fat-free mass (FFM), a hypermetabolism has been reported with an average of 10% in amyotrophic lateral sclerosis (ALS) patients as compared with a healthy population. The objectives of this study were to confirm the level of hypermetabolism determined by using indirect calorimetry in 168 patients with a probable or a definite ALS and to study correlations with survival. Consecutive evaluations of resting energy expenditure (REE) were performed from diagnosis to the proximity of death in 44 ALS patients. Differences with the calculated value determined a ΔREE. FFM was given by bioimpedance. At T₁, REE was significantly increased by an average of 14% as compared with the calculated value. 62.3% of ALS patients were considered as hypermetabolic. REE was correlated in univariate analysis with age, sex, clinical form at onset, presence of a denutrition, weight, FFM, phase angle and ALS Functional Rating Scale (ALSFRS). In multivariate analysis, REE was linked to age and FFM. ΔREE was correlated in univariate analysis with sex, phase angle and manual muscle testing (MMT). In multivariate analysis, age and sex remained significantly correlated. During progression of ALS, REE levels remained higher than calculated values with a trend to decrease at proximity of death, whereas FFM remained stable. From T₁, survival was linked to MMT, ALSFRS, vital capacity, REE and phase angle. We confirmed the existence of a stable hypermetabolic state in ALS which depends mainly on age, sex and FFM. REE is a prognostic factor for survival in univariate analysis.

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“…CRPS as paraneoplastic phenomenon has been suggested twice 159,160 . Additionally, two publications report CRPS in a patient with amyotrophic lateral sclerosis 161,162 and one publication reports CRPS in patients with Ehlers‐Danlos syndrome 163 …”

Section: Risk Factors and Determinantsmentioning

confidence: 99%

“…[138][139][140][141][142][143][144] CRPS as paraneoplastic phenomenon has been suggested twice. 159,160 Additionally, two publications report CRPS in a patient with amyotrophic lateral sclerosis 161,162 and one publication reports CRPS in patients with Ehlers-Danlos syndrome. 163 A limited number of studies on CRPS-elated disorders have been conducted in relatively small study populations.…”

Section: Related Disordersmentioning

confidence: 99%

Current Understandings on Complex Regional Pain Syndrome

Mos

Sturkenboom

Huygen³

2009

Pain Practice

139

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Abstract:The mechanisms underlying complex regional pain syndrome (CRPS) have been increasingly studied over the past decade. Classically, this painful and disabling disorder was considered to emerge from pathology of the central nervous system. However, the involvement of additional peripheral disease mechanisms is likely, and recently these mechanisms have also attracted scientific attention. The present article provides an overview of the current understandings regarding pathology of the autonomic and somatic nervous system in CRPS, as well as the roles of neurogenic inflammation, hypoxia, and the contribution of psychological factors. Potential connections between the separate disease mechanisms will be discussed. Additionally, currently known risk factors for CRPS will be addressed. Insight into risk factors is of relevance as it facilitates early diagnosis and tailored treatment. Moreover, it may provide clues for further unraveling of the pathogenesis and etiology of CRPS.

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Reflex sympathetic dystrophy associated with amyotrophic lateral sclerosis

Cited by 16 publications

References 11 publications

Pain in amyotrophic lateral sclerosis: a population‐based controlled study

Pain in amyotrophic lateral sclerosis: a population‐based controlled study

Hypermetabolism in ALS: Correlations with Clinical and Paraclinical Parameters

Current Understandings on Complex Regional Pain Syndrome

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