Reflux precipitation polymerization: a new synthetic insight in molecular imprinting at high temperature

Shen, Xiantao; Huang, Chuixiu; Shinde, Sudhirkumar; Switnicka-Plak, Magdalena A.; Cormack, Peter A. G.; Sellergren, Börje

doi:10.1039/c6ra15990g

Cited by 19 publications

(7 citation statements)

References 51 publications

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“…However, DPP could cause unstable polymerization because of the loss of solvent. To overcome the limitations, Sellergren 39 proposed reflux precipitation polymerization (RPP) at 90 1C with constant volume of the solvent during the polymerization to generate uniform MIPs. After 2 h of reaction at high temperature, the MIPs were quite uniform with a diameter of 2.0 AE 0.2 mm.…”

Section: Spherical Mips By Precipitation Polymerizationmentioning

confidence: 99%

Designing and controlling the morphology of spherical molecularly imprinted polymers

Tian

Wang

et al. 2020

Mater. Adv.

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Section: Spherical Mips By Precipitation Polymerizationmentioning

confidence: 99%

Designing and controlling the morphology of spherical molecularly imprinted polymers

Tian

Wang

et al. 2020

Mater. Adv.

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“…Precipitation polymerization has emerged as a desirable and scalable approach for the production of high-quality, uniform, and spherical imprinted particles [106,107]. The feasibility of preparing highly selective molecularly imprinting polymers using this method has recently been demonstrated [108][109][110][111]. Although a large amount of template molecules is needed for the preparation process [99], precipitation polymerization has been the most outstanding method for the synthesis of MIPs focusing on the extraction of tetracycline residues from milk, eggs and other foods.…”

Section: Sorbent Materials In Spementioning

confidence: 99%

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

Pérez-Rodríguez

Pellerano

Pezza

et al. 2018

Talanta

142

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Tetracyclines are widely used for both the treatment and prevention of diseases in animals as well as for the promotion of rapid animal growth and weight gain. This practice may result in trace amounts of these drugs in products of animal origin, such as milk and eggs, posing serious risks to human health. The presence of tetracycline residues in foods can lead to the transmission of antibiotic-resistant pathogenic bacteria through the food chain. In order to ensure food safety and avoid exposure to these substances, national and international regulatory agencies have established tolerance levels for authorized veterinary drugs, including tetracycline antimicrobials. In view of that, numerous sensitive and specific methods have been developed for the quantification of these compounds in different food matrices. One will note, however, that the determination of trace residues in foods such as milk and eggs often requires extensive sample extraction and preparation prior to conducting instrumental analysis. Sample pretreatment is usually the most complicated step in the analytical process and covers both cleaning and pre-concentration. Optimal sample preparation can reduce analysis time and sources of error, enhance sensitivity, apart from enabling unequivocal identification, confirmation and quantification of target analytes. The development and implementation of more environmentally friendly analytical procedures, which involve the use of less hazardous solvents and smaller sample sizes compared to traditional methods, is a rapidly increasing trend in analytical chemistry. This review seeks to provide an updated overview of the main trends in sample preparation for the determination of tetracycline residues in foodstuffs. The applicability of several extraction and clean-up techniques employed in the analysis of foodstuffs, especially milk and egg samples, is also thoroughly discussed.

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“…RPP can be employed to prepare MIPs with a typical process of mixing the functional monomers, template molecules, and crosslinker monomers sufficiently, and accelerating polymerization under the refluxing condition, followed by the removal of the template molecules. Chen and coworkers used RPP for the first time to fabricate uniform MIP microspheres, and demonstrated that molecular imprinting at high temperature is feasible when electrostatic interactions played main roles in the imprinting process . However, some vulnerable template molecules, such as proteins, might not be suitable for RPP approach due to the high reaction temperature.…”

Section: Polymeric Composite Nanogels For Adsorption/purification Appmentioning

confidence: 99%

Reflux Precipitation Polymerization: A New Platform for the Preparation of Uniform Polymeric Nanogels for Biomedical Applications

Fan

Wang

2018

Macromolecular Bioscience

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Reflux precipitation polymerization (RPP) represents an effective approach that enables to prepare various types of polymeric nanogels with precise control over the morphology and structure. Owing to facile loading or modification by a variety of functional moieties, rationally designed nanogels pose the possibility to attain a platform for tailoring functional properties that could be widely used for various biomedical applications, such as multifunctional drug delivery, enrichment of functional peptides, separation of specific proteins, as well as detection of circulating tumor cells. This feature article highlights RPP as a promising polymerization strategy that provides access to facile generation of modular nanostructures or multifunctional properties in a diverse range of biomedical applications, proving that RPP has great potential to become one of the most attractive polymerization techniques in polymer chemistry.

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Reflux precipitation polymerization: a new synthetic insight in molecular imprinting at high temperature

Abstract: Reflux precipitation polymerization was first used to fabricate monodispersed MIP microspheres, indicating electrostatic interaction was important for molecular imprinting at high temperature.

Cited by 19 publications

References 51 publications

Designing and controlling the morphology of spherical molecularly imprinted polymers

Designing and controlling the morphology of spherical molecularly imprinted polymers

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

Reflux Precipitation Polymerization: A New Platform for the Preparation of Uniform Polymeric Nanogels for Biomedical Applications

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