Refractory reverse amblyopia with atropine penalization

Patil, Preeti A.; Swaminathan, M. S.; Surendran, TS

doi:10.4103/0974-620x.71897

Cited by 10 publications

(5 citation statements)

References 8 publications

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“…However, there are rare cases in which the initially dominant eye may be left with lesser vision. [ 8 9 10 ] Levodopa, when not combined with patching/penalization, doesn’t cause occlusion amblyopia because both eyes are stimulated. Similarly, part time patching is also not reported to cause occlusion amblyopia whether used with or without adjunctive levodopa.…”

Section: Discussionmentioning

confidence: 99%

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Occlusion-amblyopia following high dose oral levodopa combined with part time patching

Kothari

2014

Indian J Ophthalmol

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Section: Discussionmentioning

confidence: 99%

“…Occlusion amblyopia is mostly reported to occur with atropine penalization specially when combined with optical penalization. [ 8 9 10 ]…”

Section: Discussionmentioning

confidence: 99%

Occlusion-amblyopia following high dose oral levodopa combined with part time patching

Kothari

2014

Indian J Ophthalmol

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“…Pharmacological penalization is obtained by the use of cycloplegic drugs such as atropine. 57,58 Optical penalization requires wrong lenses deliberately worn on the good eye to encourage the use of the amblyopic one and has a good therapeutic efficacy in mild to moderate amblyopia.…”

Section: Occlusion and Penalizationmentioning

confidence: 99%

Amblyopia Treatment Strategies and New Drug Therapies

Pescosolido¹,

Stefanucci²,

Buomprisco³

et al. 2014

J Pediatr Ophthalmol Strabismus

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Amblyopia is a unilateral or bilateral reduction of visual acuity secondary to abnormal visual experience during early childhood. It is one of the most common causes of vision loss and monocular blindness and is commonly associated with strabismus, anisometropia, and visual deprivation (in particular congenital cataract and ptosis). It is clinically defined as a two-line difference of best-corrected visual acuity between the eyes. The purpose of this study was to understand the neural mechanisms of amblyopia and summarize the current therapeutic strategies. In particular, the authors focused on the concept of brain plasticity and its implication for new treatment strategies for children and adults with amblyopia.

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“…This involves patching the dominant/healthy eye for 2–6 h/day, depending on the severity of the amblyopia, every day for several months up to years [ 9 ]. However, occlusion therapy carries the risk of reverse amblyopia and new strabismus by overtreatment [ 10 ]. In addition, poor adherence to the occlusion regimen is a common problem in pediatric populations (ranging from 49 to 87%), resulting in treatment failure [ 11 ] and residual amblyopia (i.e., reduced visual acuity and stereopsis that will persist into adulthood).…”

Section: Introductionmentioning

confidence: 99%

Stereoptic serious games as a visual rehabilitation tool for individuals with a residual amblyopia (AMBER trial): a protocol for a crossover randomized controlled trial

et al. 2023

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Background Amblyopia is the most common developmental vision disorder in children. The initial treatment consists of refractive correction. When insufficient, occlusion therapy may further improve visual acuity. However, the challenges and compliance issues associated with occlusion therapy may result in treatment failure and residual amblyopia. Virtual reality (VR) games developed to improve visual function have shown positive preliminary results. The aim of this study is to determine the efficacy of these games to improve vision, attention, and motor skills in patients with residual amblyopia and identify brain-related changes. We hypothesize that a VR-based training with the suggested ingredients (3D cues and rich feedback), combined with increasing the difficulty level and the use of various games in a home-based environment is crucial for treatment efficacy of vision recovery, and may be particularly effective in children. Methods The AMBER study is a randomized, cross-over, controlled trial designed to assess the effect of binocular stimulation (VR-based stereoptic serious games) in individuals with residual amblyopia (n = 30, 6–35 years of age), compared to refractive correction on vision, selective attention and motor control skills. Additionally, they will be compared to a control group of age-matched healthy individuals (n = 30) to account for the unique benefit of VR-based serious games. All participants will play serious games 30 min per day, 5 days per week, for 8 weeks. The games are delivered with the Vivid Vision Home software. The amblyopic cohort will receive both treatments in a randomized order according to the type of amblyopia, while the control group will only receive the VR-based stereoscopic serious games. The primary outcome is visual acuity in the amblyopic eye. Secondary outcomes include stereoacuity, functional vision, cortical visual responses, selective attention, and motor control. The outcomes will be measured before and after each treatment with 8-week follow-up. Discussion The VR-based games used in this study have been conceived to deliver binocular visual stimulation tailored to the individual visual needs of the patient, which will potentially result in improved basic and functional vision skills as well as visual attention and motor control skills. Trial registration This protocol is registered on ClinicalTrials.gov (identifier: NCT05114252) and in the Swiss National Clinical Trials Portal (identifier: SNCTP000005024).

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Refractory reverse amblyopia with atropine penalization

Cited by 10 publications

References 8 publications

Occlusion-amblyopia following high dose oral levodopa combined with part time patching

Occlusion-amblyopia following high dose oral levodopa combined with part time patching

Amblyopia Treatment Strategies and New Drug Therapies

Stereoptic serious games as a visual rehabilitation tool for individuals with a residual amblyopia (AMBER trial): a protocol for a crossover randomized controlled trial

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