Regarding: High Correlations Among Worldwide Prevalences of Dementias, Parkinson’s Disease, Multiple Sclerosis and Motor Neuron Diseases Indicate Common Causative Factors

Sipilä, Jussi

doi:10.1177/26331055221129634

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…On the other hand, these efforts should also be considered as a possibility to investigate the possible effects of these efforts on other disorders that are known to be influenced by environmental factors, such as AD, PD, MS and ALS. Moreover, granular nationwide data are needed to confirm or refute the suggested epidemiological links between these disorders [ 166 , 167 ].…”

Section: Perspectives and Pitfallsmentioning

confidence: 99%

Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do

Sipilä

2023

JCM

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Finland is a relatively small genetic isolate with a genetically non-homogenous population. Available Finnish data on neuroepidemiology of adult-onset disorders are limited, and this paper describes the conclusions that can be drawn and their implications. Apparently, Finnish people have a (relatively) high risk of developing Unverricht-Lundborg disease (EPM1), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), Spinal muscular atrophy, Jokela type (SMAJ) and adult-onset dystonia. On the other hand, some disorders, such as Friedreich’s ataxia (FRDA) and Wilson’s disease (WD), are almost absent or completely absent in the population. Valid and timely data concerning even many common disorders, such as stroke, migraine, neuropathy, Alzheimer’s disease and Parkinson’s disease, are unavailable, and there are virtually no data on many less-common neurological disorders, such as neurosarcoidosis or autoimmune encephalitides. There also appear to be marked regional differences in the incidence and prevalence of many diseases, suggesting that non-granular nationwide data may be misleading in many cases. Concentrated efforts to advance neuroepidemiological research in the country would be of clinical, administrative and scientific benefit, but currently, all progress is blocked by administrative and financial obstacles.

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Section: Perspectives and Pitfallsmentioning

confidence: 99%

Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do

Sipilä

2023

JCM

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“…Moreover, there are marked differences in genetic background and environmental effects in, for example, the quartet of AD, PD, ALS, and HD (Table 1) [44,[54][55][56][57]. The differences in their geographical distributions are also clear [58]. Is it a help or a hindrance to subsume all of these into the same general category?…”

Section: Neurodegeneration-the Ugly Duckling or A Red Herring?mentioning

confidence: 99%

Should we rethink neurodegeneration?

Sipilä

2022

Explor Neurosci

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The therapy of many neurological disorders has advanced markedly during recent decades. Not so for neurodegenerative disorders. Early detection, deep individual genotyping and phenotyping, and personalized therapies have been suggested as the way forward. However, we still do not know enough about the aetiology and molecular basics of these diseases. In fact, the term neurodegenerative disorder may be a misleading categorization that constitutes a major cognitive barrier against better characterization and understanding of these disorders. Therefore, we need to go back to the basics and employ novel, open-minded observational study protocols that combine very extensive and robust clinical, molecular and epidemiological data collection methods. Moreover, we need to reconsider our basic orientation towards these diseases to increase our chances of finding out what we are actually trying to care for and cure.

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Regarding: High Correlations Among Worldwide Prevalences of Dementias, Parkinson’s Disease, Multiple Sclerosis and Motor Neuron Diseases Indicate Common Causative Factors

Cited by 2 publications

References 16 publications

Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do

Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do

Should we rethink neurodegeneration?

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