1982
DOI: 10.1246/cl.1982.789
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REGENERATION OF VITAMIN E FROM Α-Chromanoxyl RADICAL BY GLUTATHIONE AND VITAMIN C

Abstract: α-Chromanoxyl radical formed by the interaction of α-tocopherol (vitamin E) with alkoxyl radical or DPPH was found by electron spin resonance spectroscopy to react with glutathione and vitamin C to regenerate α-tocopherol.

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Cited by 268 publications
(115 citation statements)
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“…The ascorbyl radical derived from ascorbic acid is oxidized to dehydroascorbate, which can be reduced to regenerate ascorbic acid. Thus, α-tocopherol and ascorbic acid inhibit lipid peroxidation synergistically 12 . Accordingly, in order to investigate the antioxidant effect in vivo, it is important to clarify the synergistic effect derived from the combination of antioxidants.…”
Section: Discussionmentioning
confidence: 99%
“…The ascorbyl radical derived from ascorbic acid is oxidized to dehydroascorbate, which can be reduced to regenerate ascorbic acid. Thus, α-tocopherol and ascorbic acid inhibit lipid peroxidation synergistically 12 . Accordingly, in order to investigate the antioxidant effect in vivo, it is important to clarify the synergistic effect derived from the combination of antioxidants.…”
Section: Discussionmentioning
confidence: 99%
“…The recycling of vitamin E takes place through the interaction between water-and fat-soluble antioxidants by nonenzymatic and/or enzymatic mechanisms, that regenerate vitamin E from its tocotrienoxyl or tocopheroxyl radical back to the active reduced forms, tocotrienol and tocopherol, respectively (Packer, 1996). Thus, the major finding in recent years is the possibility of direct or indirect vitamin E recycling from its oxidised radical form by means of ascorbate (Chap et al, 1991;Chan, 1993), glutathione (Niki et al, 1982;Chan, 1993), cysteine (Motoyama et al, 1989), ubiquinols (Freisleben andPacker, 1993;Chan, 1993), lipoic acid (Packer, 1998) and carotenoids Bohm et al, 1997). Enzymatic regeneration of a-tocopherol has been also described (Maguire et al, 1989).…”
Section: Conclusion: Future Developmentsmentioning
confidence: 99%
“…But the mode of action of most of those synergists was in different ways. For example, ascorbic acid can act as synergist with tocopherols by regenerating or restoring their antioxidant properties [13]. Ascorbic acid and its esterified derivatives may also function as oxygen scavengers.…”
Section: Synergistic Effectmentioning
confidence: 99%