Regenerative Approaches in Gingival Tissue Engineering

Abstract

Gingival tissue engineering aims to regenerate damaged or diseased gingival tissues by applying biomaterials, growth factors, and stem cells. This chapter explores advancements and strategies in gingival tissue engineering. It begins by introducing the goals and anatomy/physiology of the gingiva. Biomaterial selection and design for gingival scaffolds and delivery methods for bioactive molecules to stimulate tissue growth are discussed. Stem cells are highlighted for their role in gingival regeneration - their isolation, characterization, and differentiation. Strategies like cell-based approaches, scaffold-free techniques, and hybrids combining cells, scaffolds, and growth factors are outlined. Preclinical and clinical studies assessing treatment safety/efficacy and methods to evaluate outcomes are reviewed. Challenges around improving cell viability, integration, and function are examined. Future directions focus on addressing these challenges. Ethical considerations and regulatory aspects are addressed to ensure responsible translation into clinical practice. This chapter provides insights into the current state and prospects of regenerative approaches in gingival tissue engineering, including their potential to impact gingival disease treatment and oral health promotion.