Regenerative effect of the polydeoxyribonucleotide after sciatic nerve transection in mouse

Park, Ji-Woen; Kim, Min Su; Kim, Seok-Kwun; Lee, Keun-Cheol; Jinwha, Lee

doi:10.1007/s13770-015-0023-5

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…However, its relatively slow nerve regeneration (re‐extension) and limited nerve regeneration distance remains as a significant huddle for clinical use . To compensate the inherent limitation of NGCs, bioactive molecules such as nerve growth factor (NGF), glial‐derived neurotrophic factor (GDNF), neurotrophin‐3 (NT‐3), transforming growth factor‐β 1 (TGF‐β 1 ), and vascular endothelial growth factor (VEGF) were introduced on the NGCs and some encouraging outcomes have been reported. In more recent years, the biomimicking of the nerve development/regeneration, in terms of bioactive molecules, was also attempted for nerve regeneration.…”

Section: Introductionmentioning

confidence: 99%

Enhanced peripheral nerve regeneration through asymmetrically porous nerve guide conduit with nerve growth factor gradient

Kang

Kim

et al. 2017

J Biomedical Materials Res

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In this study, we fabricated a nerve guide conduit (NGC) with nerve growth factor (NGF) gradient along the longitudinal direction by rolling a porous polycaprolactone membrane with NGF concentration gradient. The NGF immobilized on the membrane was continuously released for up to 35 days, and the released amount of the NGF from the membrane gradually increased from the proximal to distal NGF ends, which may allow a neurotrophic factor gradient in the tubular NGC for a sufficient period. From the in vitro cell culture experiment, it was observed that the PC12 cells sense the NGF concentration gradient on the membrane for the cell proliferation and differentiation. From the in vivo animal experiment using a long gap (20 mm) sciatic nerve defect model of rats, the NGC with NGF concentration gradient allowed more rapid nerve regeneration through the NGC than the NGC itself and NGC immobilized with uniformly distributed NGF. The NGC with NGF concentration gradient seems to be a promising strategy for the peripheral nerve regeneration.

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Section: Introductionmentioning

confidence: 99%

Enhanced peripheral nerve regeneration through asymmetrically porous nerve guide conduit with nerve growth factor gradient

Kang

Kim

et al. 2017

J Biomedical Materials Res

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“…However, the effects of these drugs are mainly due to an anti-inflammatory effect, whereas PDRN has the advantage of having both anti-inflammatory and anti-ischemic effects. We also expect PDRN to have an additional effect in spinal stenosis through regenerative effects on spinal nerve degeneration [ 39 , 40 ]. Further, PDRN was not associated with organ toxicity in previous animal studies [ 19 , 41 ], and post-marketing surveillance has confirmed its safety [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of epidural polydeoxyribonucleotide in a rat model of lumbar foraminal stenosis

Lee

Choi

et al. 2021

Korean J Pain

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Background We aimed to investigate the effect of epidural polydeoxyribonucleotide (PDRN) on mechanical allodynia and motor dysfunction in a rat model of lumbar foraminal stenosis (LFS). Methods This study was conducted in two stages, using male Sprague-Dawley rats. The rats were randomly divided into eight groups. In the first stage, the groups were as follows vehicle (V), sham (S), and epidural PDRN at 5 (P5), 8 (P8), and 10 (P10) mg/kg; and in the second stage, they were as follows intraperitoneal PDRN 8 mg/kg, epidural 3,7-dimethyl-1-propargilxanthine (DMPX) (0.1 mg/kg), and DMPX (0.1 mg/kg). The LFS model was established, except for the S group. After an epidural injection of the test solutions, von Frey and treadmill tests were conducted for 3 weeks. Subsequently, histopathologic examinations were conducted in the V, S, P5, and P10 groups. Results A total of 65 rats were included. The P8 and P10 groups showed significant recovery from mechanical allodynia and motor dysfunction at all time points after drug administration compared to the V group. These effects were abolished by concomitant administration of DMPX. On histopathological examination, no epineurial inflammation or fibrosis was observed in the epidural PDRN groups. Conclusions Epidural injection of PDRN significantly improves mechanical allodynia and motor dysfunction in a rat model of LFS, which is mediated by the spinal adenosine A 2A receptor. The present data support the need for further research to determine the role of epidural PDRN in spinal stenosis treatment.

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“…51 This confirmed a previous study by Park et al that demonstrated that PDRN facilitated nerve regeneration by promoting VEGF expression after sciatic nerve transection in a mouse model. 67 Yun et al 68 demonstrated that PDRN, alone or in combination with HA, decreased wound size and cell apoptosis by a TUNEL assay.…”

Section: Pdrn and Antiapoptotic Effectsmentioning

confidence: 99%

Polydeoxyribonucleotide Regulation of Inflammation

Colangelo

Galli

Guizzardi

2020

Advances in Wound Care

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Significance: Dysregulated inflammation is a critical factor in the development of a wide range of diseases. Controlling inflammatory responses can be challenging because available treatment options are often limited. This review discusses the ability of polydeoxyribonucleotides (PDRN) to modulate inflammation and the evidence that supports it. Recent Advances: PDRN is known in the clinical field for its regenerative properties. This action is partially related to the stimulation of the purinergic system through adenosine A2A receptors (A2ARs). Recently, the topical antiinflammatory effects of PDRN have aroused much interest, with a growing body of research supporting its use for the management of several inflammatory states. Critical Issues: Impaired tissue repair and several metabolic disorders are associated with chronic inflammation. Despite the growing clinical concern, an optimal and sustainable therapy for different inflammatory conditions has not yet been established, and current treatments are often limited by their short-term efficacies and side effects. Future Directions: The present review provides an updated summary of the ability of PDRN to control inflammation as observed in several in vitro studies, simplified models of the main biological mechanisms mediating its anti-inflammatory effect, and confirmed in vivo and clinical models. It analyzes the therapeutic potential of PDRN in terms of its mechanism of action through A2AR activation, its efficacy and its complications compared with those of current anti-inflammatory drugs.

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Regenerative effect of the polydeoxyribonucleotide after sciatic nerve transection in mouse

Cited by 3 publications

References 27 publications

Enhanced peripheral nerve regeneration through asymmetrically porous nerve guide conduit with nerve growth factor gradient

Enhanced peripheral nerve regeneration through asymmetrically porous nerve guide conduit with nerve growth factor gradient

Effect of epidural polydeoxyribonucleotide in a rat model of lumbar foraminal stenosis

Polydeoxyribonucleotide Regulation of Inflammation

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