Regenerative Endodontics by Cell Homing: A Review of Recent Clinical trials

Yan, Hongji; Deus, Gustavo De; Kristoffersen, Ida Marie; Wiig, Elisabeth H.; Reseland, Janne Elin; Johsen, Gaute F.; Silva, Emmanuel J.N. L.; Haugen, Håvard Jostein

doi:10.1016/j.joen.2022.09.008

Cited by 28 publications

(18 citation statements)

References 86 publications

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“…Conversely, younger individuals may have a wider apical foramen and may also possess stem cells with a greater regenerative capacity; adult patients might require alternative approaches to ensure success. For this reason, it is controversial to recommend REPs by cell homing for adults or patients older than 30 years 29,30 .…”

Section: Discussionmentioning

confidence: 99%

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Martínez,

Oyonarte,

Concha

et al. 2024

Preprint

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Background Regenerative endodontic procedures (REPs) are innovative treatments aimed at restoring damaged dental structures. However, the effect of orthodontic movement on REP-treated teeth is not well understood and may have significant long-term consequences. This study aimed to evaluate the impact of orthodontic movement on a mature permanent tooth associated with dens invaginatus that has undergone a regenerative endodontic procedure (REP). Case presentation: This case involves a preliminary investigation into the effects of orthodontic movements on a mature REP-treated tooth. This could have the potential to enrich our collective understanding and guide treatment planning, leading to the development of clinical guidelines. This report describes the case of a 13-year-old male with a noncontributory medical history who presented with pulp necrosis and a chronic apical abscess (tooth number 2.2). Following REP according to the American Association of Endodontists' guidelines, the patient began orthodontic treatment after 9 months. Subsequent follow-ups at 9 months, 2 years, and 3 years post-REP revealed an asymptomatic state with minimal cervical discolouration and diminished cold sensitivity. Radiographic analyses revealed periapical healing, dentin wall thickening, and consistent root length. The treated tooth displayed a positive response to both REP and orthodontic treatment, yet further research is necessary to determine the long-term effects of orthodontic forces on REP-treated teeth. Conclusion Our findings suggest that orthodontic movement following REPs in mature permanent teeth is feasible and may also act as a protective factor against apical root resorption. Our experience indicates that a 9-month healing period permits successful orthodontic outcomes following REPs. Nonetheless, the predictability of outcomes and the ideal healing period before orthodontic movement is initiated remain to be established.

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Section: Discussionmentioning

confidence: 99%

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Martínez,

Oyonarte,

Concha

et al. 2024

Preprint

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“…The results demonstrated successful pulp revascularization and continued root development, highlighting the therapeutic potential of SCAP in regenerative endodontic procedures. DFSCs, isolated from the dental follicle tissue surrounding developing teeth, have also shown the capacity to differentiate into dental pulp-like cells [12,13]. Studies have reported favorable outcomes, including the regeneration of functional dental pulp, continued root development and improved tooth vitality.…”

Section: Stem Cellsmentioning

confidence: 99%

Regenerative Endodontics -Present Practice to Promising Prospects: A Literature Review

Mujawar

2024

JDHOR

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Regenerative endodontics is an innovative field within dentistry that aims to restore damaged dental pulp using stem cells, tissue engineering techniques and biocompatible materials. This article provides an overview of the current trends in regenerative endodontics, highlighting recent research findings. Stem cells obtained from different sources like dental pulp, bone marrow and adipose tissue possess the ability to differentiate into cells similar to dental pulp and facilitate the regeneration of tissues. The use of biocompatible substances, such as Mineral Trioxide Aggregate (MTA) biodentine, offers an ideal setting for tissue growth and healing. Dental scaffolds, made from biodegradable materials, support the development of new blood vessels, nerve fibers and dental pulp-like tissues. Growth factors, like PDGF and TGF-β, are incredibly important in stimulating cell growth and specialization. Researchers and clinical trials are currently working on improving regenerative endodontic procedures, with promising results seen in terms of pulp regeneration and root development. By embracing these trends, dental professionals can offer innovative solutions for restoring damaged dental pulp and preserving natural teeth. The present article, is an overview of regenerative endodontics, exploring the current trends that are shaping the future of this field.

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“…[1] Though these methods are advantageous, high risk of reinfection and tooth breakage occurred due to reduced mechanical strength of dentin, immune responses, and somatic sensory functions. [2] To overcome these problems, regenerative endodontic procedures are utilized.…”

Section: Introductionmentioning

confidence: 99%

Regenerative Endodontics – A Review

2023

PIJR

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Regenerative endodontic procedure is a biologically based management for necrotic pulp in developing permanent teeth. The main goals of regenerative endodontics are regeneration of the pulp and dentin complex, increased teeth lifetime and to establish normal function. Regenerative endodontics aims to maintain the tooth's life and sensitivity while preventing necrosis it tries to regenerate the injured 'pulp-like' tissue .This review summarizes the methods created for pulp regeneration and complications based on recent biologic foundation and current clinical guidelines used in regenerative endodontics and discusses future strategies for pulp regeneration.

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Regenerative Endodontics by Cell Homing: A Review of Recent Clinical trials

Cited by 28 publications

References 86 publications

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Regenerative Endodontics -Present Practice to Promising Prospects: A Literature Review

Regenerative Endodontics – A Review

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