Regenerative Medicine and the Developing World

Greenwood, Heather; Сингер, Петер; Downey, Gregory P.; Martin, Douglas K.; Thorsteinsdóttir, Halla; Daar, Abdallah S.

doi:10.1371/journal.pmed.0030381

Cited by 69 publications

(40 citation statements)

References 14 publications

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“…This can potentially be accomplished using the process of dedifferentiation (which involves terminally differentiated cells reverting back to a less differentiated stage), transdifferentiation (a processes which takes dedifferentiation a step further and cells differentiate into a cell type of another lineage) and reprogramming (which aims to induce differentiated cells into a pluripotent state) [26]. Regenerative therapies consist of different technological approaches, such as soluble molecules, gene targeting, stem cell treatment, tissue engineering and cell reprogramming [41]. In this review we are only discussing the existing cell-based and growth factor-based in vitro and in vivo studies and therapies that are at preclinical and clinical level.…”

Section: Regenerative Therapies For Skin Wound Managementmentioning

confidence: 99%

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

Borena

Martens

Broeckx

et al. 2015

Cell Physiol Biochem

171

112

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Mammal skin has a crucial function in several life-preserving processes such as hydration, protection against chemicals and pathogens, initialization of vitamin D synthesis, excretion and heat regulation. Severe damage of the skin may therefore be life-threatening. Skin wound repair is a multiphased, yet well-orchestrated process including the interaction of various cell types, growth factors and cytokines aiming at closure of the skin and preferably resulting in tissue repair. Regardless various therapeutic modalities targeting at enhancing wound healing, the development of novel approaches for this pathology remains a clinical challenge. The time-consuming conservative wound management is mainly restricted to wound repair rather than restitution of the tissue integrity (the so-called “restitutio ad integrum”). Therefore, there is a continued search towards more efficacious wound therapies to reduce health care burden, provide patients with long-term relief and ultimately scarless wound healing. Recent in vivo and in vitro studies on the use of skin wound regenerative therapies provide encouraging results, but more protracted studies will have to determine whether the effect of observed effects are clinically significant and whether regeneration rather than repair can be achieved. For all the aforementioned reasons, this article reviews the emerging field of regenerative skin wound healing in mammals with particular emphasis on growth factor- and stem cell-based therapies.

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Section: Regenerative Therapies For Skin Wound Managementmentioning

confidence: 99%

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

Borena

Martens

Broeckx

et al. 2015

Cell Physiol Biochem

171

112

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“…There are possibilities for regenerating the diseased, injured or traumatized oral mucosal tissues using dental stem cells. Regenerative medicine is defined as an emerging interdisciplinary field of research and clinical applications focused on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function resulting from any cause, including congenital defects, disease, trauma and ageing 2 .The term Tissue Engineering was first coined by Y.C Fung , a pioneer in the field of biomechanics and bioengineering in 1985 which is in fact a part of regenerative medicine 1 .Tissue engineering is defined as an interdisciplinary field that applies the principles of engineering and life sciences, towards the development of biological substitutes that restore, maintain or improve tissue function ( Langer and Vacanti,1993) 3 . In the last decade, dentistry has begun to explore the potential application of stem cells and tissue engineering towards the repair and regeneration of dental structures.…”

Section: Introductionmentioning

confidence: 99%

Role of Dental Stem Cells in Regenerative Medicine

2016

IJSR

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Stem cell therapy has a promising future for tissue engineering and regenerative medicine. However stem cell technology is still in its infancy, interdisciplinary co-operation is needed to achieve successful clinical applications. Dental stem cells have drawn attention in recent years because of their accessibility, plasticity and high proliferative ability. Several types of dental stem cells have been identified, which include those derived from adult human dental pulp, primary exfoliated deciduous teeth, periodontal ligament, dental follicle and permanent third molars. Similar to mesenchymal stem cells, they also undergo self renewal and have multipotent differentiation ability, but do not have the ethical issues associated with the other sources of stem cells. This review describes about the potential of different types of dental stem cells.

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“…According to European Commission [6], tissue engineering is the regeneration of biological tissue through the use of cells, with the aid of supporting structures and/or biomolecules. Regenerative medicine is defined as an emerging interdisciplinary field of research and clinical applications focused on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function resulting from any cause, including congenital defects, disease, trauma and aging [7]. Tissue engineering is basically, one part of the major components of regenerative medicine which follows the principles of cell transplantation, materials science and engineering towards the development of biological substitutes which can restore and maintain normal function [8].…”

Section: Introductionmentioning

confidence: 99%

DPSCs and SHED in Tissue Engineering and Regenerative Medicine

Abdullah¹

2013

TOSCJ

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Dental pulp stem cells (DPSCs) from permanent teeth and stem cells from human exfoliated deciduous teeth (SHED) have attracted tremendous interest recently by playing a major role in tissue engineering and regenerative medicine. However, since stem cell technology is still in its infancy, interdisciplinary cooperation between medicine, basic biological research, nanotechnology and materials science is needed to achieve successful clinical applications. Similar to mesenchymal stem cells, DPSCs and SHED can undergo self-renewal and have multipotent differentiation ability, but unlike other sources of stem cells such as embryonic stem cells, which involves the destruction of human embryo, DPSCs and SHED have limited ethical concerns as they are readily and easily accessible, non-invasive and disposed off naturally. Not only DPSCs and SHED can be used for cell based therapies and bio-artificial tissue constructs but also made to differentiate into other cell types. Here, we discuss on definitions, opportunities, advantages and limitations of DPSCs and SHED in tissue engineering and regenerative medicine.

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Regenerative Medicine and the Developing World

Abstract: This is the first study to systematically identify and prioritize which applications of regenerative medicine are the most promising for improving health in developing countries.

Cited by 69 publications

References 14 publications

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

Role of Dental Stem Cells in Regenerative Medicine

DPSCs and SHED in Tissue Engineering and Regenerative Medicine

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