Regenerative medicine for the upper gastrointestinal tract

Kanetaka, Kengo; Eguchi, Susumu

doi:10.1016/j.reth.2020.07.002

Cited by 13 publications

(11 citation statements)

References 99 publications

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“…Decellularized scaffolds have shown promising prospects in the repair of organ defects or replacement of malfunctioning parts of the gastrointestinal tract and have attracted great interest from researchers in the field of gastroenterology. 29,30 In this study, DIS were prepared, and surface modification was carried out by incubation in PDA. Then, ADSC were implanted on PDA-DIS to form composite scaffolds for the repair of intestinal defects in rats.…”

Section: Discussionmentioning

confidence: 99%

Polydopamine-modified decellularized intestinal scaffolds loaded with adipose-derived stem cells promote intestinal regeneration

Wan

Wang

et al. 2023

J. Mater. Chem. B

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Section: Discussionmentioning

confidence: 99%

Polydopamine-modified decellularized intestinal scaffolds loaded with adipose-derived stem cells promote intestinal regeneration

Wan

Wang

et al. 2023

J. Mater. Chem. B

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“…In this case, the surgery requires the complete resection of the diseased tissue and musculoskeletal, vascular, and/or nerve reconstruction to enable the return to the acquired physiological and bodily functionality. Traditionally, organ/tissue reconstruction is performed using autologous materials; for example, the resected esophagus is replaced with an autologous intestine conduit [ 15 ]. On the latter, nowadays, improvements in tissue engineering and regenerative medicine are developing synthetic biodegradable and biocompatible engineered scaffolds that are emerging as alternative and useful organ substitutes [ 16 , 17 ].…”

Section: Head-and-neck Cancersmentioning

confidence: 99%

Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination

Pisani

Bertino

Prina-Mello

et al. 2022

Cancers

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Squamous cell carcinoma is the most common malignancy that arises in the head-and-neck district. Traditional treatment could be insufficient in case of recurrent and/or metastatic cancers; for this reason, more selective and enhanced treatments are in evaluation in preclinical and clinical trials to increase in situ concentration of chemotherapy drugs promoting a selectively antineoplastic activity. Among all cancer treatment types (i.e., surgery, chemotherapy, radiotherapy), electroporation (EP) has emerged as a safe, less invasive, and effective approach for cancer treatment. Reversible EP, using an intensive electric stimulus (i.e., 1000 V/cm) applied for a short time (i.e., 100 μs), determines a localized electric field that temporarily permealizes the tumor cell membranes while maintaining high cell viability, promoting cytoplasm cell uptake of antineoplastic agents such as bleomycin and cisplatin (electrochemotherapy), calcium (Ca2+ electroporation), siRNA and plasmid DNA (gene electroporation). The higher intracellular concentration of antineoplastic agents enhances the antineoplastic activity and promotes controlled tumor cell death (apoptosis). As secondary effects, localized EP (i) reduces the capillary blood flow in tumor tissue (“vascular lock”), lowering drug washout, and (ii) stimulates the immune system acting against cancer cells. After years of preclinical development, electrochemotherapy (ECT), in combination with bleomycin or cisplatin, is currently one of the most effective treatments used for cutaneous metastases and primary skin and mucosal cancers that are not amenable to surgery. To reach this clinical evidence, in vitro and in vivo models were preclinically developed for evaluating the efficacy and safety of ECT on different tumor cell lines and animal models to optimize dose and administration routes of drugs, duration, and intensity of the electric field. Improvements in reversible EP efficacy are under evaluation for HNSCC treatment, where the focus is on the development of a combination treatment between EP-enhanced nanotechnology and immunotherapy strategies.

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“…In addition to Table 1 (a, b and c), readers may profit from reading several review articles [75,[164][165][166][167][168][169][170].…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…Also, we need to obtain a high degree of differentiation of epithelial cells to effectively protect the body during digestion and a strongly acidic environment. The most fruitful results have come from the reconstruction of stomach patches [169]. Progress in the knowledge of stem cells, the organization of their niches and the processes of differentiation into various cell types are therefore necessary to reconstruct this tissue.…”

Section: Tissue Engineeringmentioning

confidence: 99%

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Tissue Engineering for Gastrointestinal and Genitourinary Tracts

Elia¹,

Brownell²,

Chabaud³

et al. 2022

Preprint

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The gastrointestinal and genitourinary tracts share several similarities. Primarily, these tissues are composed of hollow structures lined by an epithelium through which materials need to flow with the help of peristalsis brought by muscle contraction. In the case of the gastrointestinal tract, solid or liquid food must circulate to be digested and absorbed and the waste products eliminated. In the case of the urinary tract, the urine produced by the kidneys must flow to the bladder, where it is stored until its elimination from the body. Finally, in the case of the vagina, it must allow the evacuation of blood during menstruation, accommodate the male sexual organ during coitus, and is the natural way to birth a child. The present review describes the anatomy, pathologies and treatments of such organs, emphasizing tissue engineering strategies.

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Regenerative medicine for the upper gastrointestinal tract

Cited by 13 publications

References 99 publications

Polydopamine-modified decellularized intestinal scaffolds loaded with adipose-derived stem cells promote intestinal regeneration

Polydopamine-modified decellularized intestinal scaffolds loaded with adipose-derived stem cells promote intestinal regeneration

Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination

Tissue Engineering for Gastrointestinal and Genitourinary Tracts

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