Regenerative Therapy Using Umbilical Cord Serum

Maharajan, Nagarajan; Cho, Gwang-Won; Choi, Ji Hyun; Jang, Chul Ho

doi:10.21873/invivo.12310

Cited by 13 publications

(14 citation statements)

References 58 publications

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“…Furthermore, examining UC serum/plasma samples is a great means of detecting the elemental input of the fetus via the placenta and amniotic fluid [ 15 ]. UC serum can provide meaningful information about prenatal exposure in addition to being an easily assessed type of sample after the delivery [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy

Jagodić

Pavlović

Borković-Mitić

et al. 2022

IJMS

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With the ever-growing concern for human health and wellbeing, the prenatal period of development requires special attention since fetuses can be exposed to various metals through the mother. Therefore, this study explored the status of selected toxic (Pb, Cd, Ni, As, Pt, Ce, Rb, Sr, U) and essential trace metals (Mn, Co, Cu, Zn, Se) in the umbilical cord (UC) sera, maternal sera, and placental tissue samples of 92 healthy women with normal pregnancies. A further aim focuses on the potential transplacental transfer of these trace metals. Based on the obtained levels of investigated elements in clinical samples, it was observed that all of the trace metals cross the placental barrier and reach the fetus. Furthermore, statistical analysis revealed significant differences in levels of toxic Ni, As, Cd, U, Sr, Rb, and essential Mn, Cu, and Zn between all three types of analyzed clinical samples. Correlation analysis highlighted As to be an element with levels that differed significantly between all tested samples. Principal component analysis (PCA) was used to enhance these findings. PCA demonstrated that Cd, Mn, Zn, Rb, Ce, U, and Sr were the most influential trace metals in distinguishing placenta from maternal and UC serum samples. As, Co, and Cu were responsible for the clustering of maternal serum samples, and PCA demonstrated that the Pt level in UC sera was responsible for the clustering of these samples. Overall, the findings of this study could contribute to a better understanding of transplacental transfer of these trace metals, and shed a light on overall levels of metal exposure in the population of healthy pregnant women and their fetuses.

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Section: Introductionmentioning

confidence: 99%

Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy

Jagodić

Pavlović

Borković-Mitić

et al. 2022

IJMS

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“…In this context, recent studies have focused on using the acellular fractions of the hUC blood, namely the human umbilical cord serum (hUCS) and plasma (hUCP) (Figure 1B). Since their GFs and cytokines produced comparable anti-inflammatory, angiogenic, and anti-apoptotic effects, the main difference between both biofluids is the absence (hUCS) or presence (hUCP) of clotting factors [114,115]. In addition, since hUCS and hUCP resemble the 'culture medium' of hUC blood cells, it is possible that they contain some GFs secreted by hUC-MSCs, and therefore partly contribute to tissue regeneration processes [104].…”

Section: The Acellular Fractionsmentioning

confidence: 99%

Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine

Rodríguez-Eguren

Gómez-Álvarez²,

Francés-Herrero

et al. 2022

IJMS

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There are several conditions that lead to female infertility, where traditional or conventional treatments have limited efficacy. In these challenging scenarios, stem cell (SC) therapies have been investigated as alternative treatment strategies. Human umbilical cord (hUC) mesenchymal stem cells (hUC-MSC), along with their secreted paracrine factors, extracts, and biomolecules, have emerged as promising therapeutic alternatives in regenerative medicine, due to their remarkable potential to promote anti-inflammatory and regenerative processes more efficiently than other autologous treatments. Similarly, hUC blood derivatives, such as platelet-rich plasma (PRP), or isolated plasma elements, such as growth factors, have also demonstrated potential. This literature review aims to summarize the recent therapeutic advances based on hUC-MSCs, hUC blood, and/or other plasma derivatives (e.g., extracellular vesicles, hUC-PRP, and growth factors) in the context of female reproductive medicine. We present an in-depth analysis of the principal molecules mediating tissue regeneration, compiling the application of these therapies in preclinical and clinical studies, within the context of the human reproductive tract. Despite the recent advances in bioengineering strategies that sustain delivery and amplify the scope of the therapeutic benefits, further clinical trials are required prior to the wide implementation of these alternative therapies in reproductive medicine.

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“…Regenerative medicine covers "the process of replacing, engineering or regenerating human cells, tissues or organs to restore the tissue or organ normal function" [6]. In regenerative medicine, in vivo regeneration of tissues happens by use of human body as a bioreactor to augment the body's innate ability to regenerate and heal.…”

Section: Regenerative Medicine and Cell Transplantation Conceptmentioning

confidence: 99%

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Kaboodkhani

Mehrabani

Karimi‐Busheri

2021

JCM

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Otorhinolaryngology enrolls head and neck surgery in various tissues such as ear, nose, and throat (ENT) that govern different activities such as hearing, breathing, smelling, production of vocal sounds, the balance, deglutition, facial animation, air filtration and humidification, and articulation during speech, while absence of these functions can lead to high morbidity and even mortality. Conventional therapies for head and neck damaged tissues include grafts, transplants, and artificial materials, but grafts have limited availability and cause morbidity in the donor site. To improve these limitations, regenerative medicine, as a novel and rapidly growing field, has opened a new therapeutic window in otorhinolaryngology by using cell transplantation to target the healing and replacement of injured tissues. There is a high risk of rejection and tumor formation for transplantation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs) lack these drawbacks. They have easy expansion and antiapoptotic properties with a wide range of healing and aesthetic functions that make them a novel candidate in otorhinolaryngology for craniofacial defects and diseases and hold immense promise for bone tissue healing; even the tissue sources and types of MSCs, the method of cell introduction and their preparation quality can influence the final outcome in the injured tissue. In this review, we demonstrated the anti-inflammatory and immunomodulatory properties of MSCs, from different sources, to be safely used for cell-based therapies in otorhinolaryngology, while their achievements and challenges have been described too.

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Regenerative Therapy Using Umbilical Cord Serum

Cited by 13 publications

References 58 publications

Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy

Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy

Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

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