Recently, the problem of psychological status of students, including university students, and its influence on the health of the individual has become very relevant. The applicants entering higher education institutions of our county face an especially difficult period. They have to deal with a lot of exams affecting their future destiny, the complicated process of adaptation to the new training conditions existing in the educational institutions, as well as with the completely unfamiliar team of teachers and students. The study was aimed to perform comparative analysis of psychological health of the students attending the medical university and to determine the indicators most strongly affecting the students’ quality of life and body’s condition. A total of 1050 first-year, third-year, and sixth-year students of the medical university were enrolled. Each subject was offered to voluntarily pass three different tests to determine his/her psychological status. The scores of functional reserve of the CNS below 50% were reported for more than one third of students of the pediatric faculty (39%). In students of the faculty of pediatrics, the decreased performance was observed in 51% of cases, mostly in females. To summarize, it is worth noting, that medical students, especially first-year students, often have psychological health problems.