Region‐specific gene expression in early postnatal mouse thalamus

Yuge, Kazuya; Kataoka, Ayane; Yoshida, Aya; Itoh, Daisuke; Aggarwal, Manisha; Mori, Susumu; Blackshaw, Seth; Shimogori, Tomomi

doi:10.1002/cne.22532

Cited by 56 publications

(83 citation statements)

References 49 publications

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“…In amphibians and amniotes, the prethalamus is further characterized by expression of the proneural bHLH genes, Olig2 and Mash1, and a GABAergic neurotransmitter phenotype (Andrews et al, 2003;Brox et al, 2003;Os orio et al, 2010;Yuge et al, 2011). Our unpublished data and results of previous studies confirmed that zebrafish olig2 and ascl1a are expressed in the embryonic prethalamus Mueller, 2002, 2004b;Tiso et al, 2009;Scholpp et al, 2009) and GABAergic neurons were also found (Mueller et al, 2006).…”

Section: Molecular Characterization Of the Prethalamussupporting

confidence: 90%

“…Both in zebrafish and mouse, the two thalamic progenitor domains translate during development into different functional domains with neurons of different neurotransmitter phenotypes. pTH-R contributes to GABAergic and pTH-C to glutamatergic neurons that are specified by ascl1a/ Mash1 and ngn1/Ngn2 pathways, respectively (Mueller et al, 2006;Vue et al, 2007Vue et al, , 2009Scholpp et al, 2009;Os orio et al, 2010;Yuge et al, 2011). These comparative data suggest a conservation of rostral and caudal thalamic progenitor domains in zebrafish and mouse.…”

Section: Rostral and Caudal Thalamic Domainsmentioning

confidence: 75%

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Molecular characterization of prosomeric and intraprosomeric subdivisions of the embryonic zebrafish diencephalon

Lauter

Söll

Hauptmann

2013

J of Comparative Neurology

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During development of the early neural tube, positional information provided by signaling gradients is translated into a grid of transverse and longitudinal transcription factor expression domains. Transcription factor specification codes defining distinct histogenetic domains within this grid are evolutionarily conserved across vertebrates and may reflect an underlying common vertebrate bauplan. When compared to the rich body of comparative gene expression studies of tetrapods, there is considerably less comparative data available for teleost fish. We used sensitive multicolor fluorescent in situ hybridization to generate a detailed map of regulatory gene expression domains in the embryonic zebrafish diencephalon. The high resolution of this technique allowed us to resolve abutting and overlapping gene expression of different transcripts. We found that the relative topography of gene expression patterns in zebrafish was highly similar to those of orthologous genes in tetrapods and consistent with a three-prosomere organization of the alar and basal diencephalon. Our analysis further demonstrated a conservation of intraprosomeric subdivisions within prosomeres 1, 2, and 3 (p1, p2, and p3). A tripartition of zebrafish p1 was identified reminiscent of precommissural (PcP), juxtacommissural (JcP), and commissural (CoP) pretectal domains of tetrapods. The constructed detailed diencephalic transcription factor gene expression map further identified molecularly distinct thalamic and prethalamic rostral and caudal domains and a prethalamic eminence histogenetic domain in zebrafish. Our comparative gene expression analysis conformed with the idea of a common bauplan for the diencephalon of anamniote and amniote vertebrates from fish to mammals.

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Section: Molecular Characterization Of the Prethalamussupporting

confidence: 90%

Section: Rostral and Caudal Thalamic Domainsmentioning

confidence: 75%

Molecular characterization of prosomeric and intraprosomeric subdivisions of the embryonic zebrafish diencephalon

Lauter

Söll

Hauptmann

2013

J of Comparative Neurology

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“…However, both Foxp2 and CTGF showed different expression patterns in neonatal marmoset brain. High-level expression of Foxp2 expression in mouse cortex in layer 6b and some additional staining was observed in somatosensory layer 4 (Yuge et al, 2011). In neonatal marmoset PFC, we observed strong expression of Foxp2 in layer 6, but in more caudal regions, the expression in layer 6 became weaker, and expression in layers 5 and 4 became much stronger (data not shown).…”

Section: Primate-specific Gene Expression In the Pfcmentioning

confidence: 64%

“…1), whose expression has been reported in mouse thalamus (Suzuki-Hirano et al, 2011;Yuge et al, 2011). Kitl, Ntng2, and Zic1 showed strong expression in the pulvinar and medial geniculate body (MG) (Fig.…”

Section: Gene Expression In Afferent Regions Of the Pfc-pulvinarmentioning

confidence: 78%

Comparative Anatomy of Marmoset and Mouse Cortex from Genomic Expression

et al. 2012

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Advances in mouse neural circuit genetics, brain atlases, and behavioral assays provide a powerful system for modeling the genetic basis of cognition and psychiatric disease. However, a critical limitation of this approach is how to achieve concordance of mouse neurobiology with the ultimate goal of understanding the human brain. Previously, the common marmoset has shown promise as a genetic model system toward the linking of mouse and human studies. However, the advent of marmoset transgenic approaches will require an understanding of developmental principles in marmoset compared to mouse. In this study, we used gene expression analysis in marmoset brain to pose a series of fundamental questions on cortical development and evolution for direct comparison to existing mouse brain atlas expression data. Most genes showed reliable conservation of expression between marmoset and mouse. However, certain markers had strikingly divergent expression patterns. The lateral geniculate nucleus and pulvinar in the thalamus showed diversification of genetic organization between marmoset and mouse, suggesting they share some similarity. In contrast, gene expression patterns in early visual cortical areas showed marmoset-specific expression. In prefrontal cortex, some markers labeled architectonic areas and layers distinct between mouse and marmoset. Core hippocampus was conserved, while afferent areas showed divergence. Together, these results indicate that existing cortical areas are genetically conserved between marmoset and mouse, while differences in areal parcellation, afferent diversification, and layer complexity are associated with specific genes. Collectively, we propose that gene expression patterns in marmoset brain reveal important clues to the principles underlying the molecular evolution of cortical and cognitive expansion.

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“…To investigate the expression pattern of genes that showed prominent thalamic expression in greater detail, we performed ISH for these transcripts at embryonic day (E)10.5, E12.5, and E15.5 and at postnatal day (P)6. In a companion paper, we describe a number of genes that show restricted expression in different regions of the thalamus (Yuge et al, 2011). In this paper, we report the expression patterns of genes that show particularly prominent and selective expression in the embryonic thalamic ventricular zone (VZ) and thalamic mantle zone, with a focus on genes that show prominent regionally restricted expression within the mantle zone.…”

Section: Introductionmentioning

confidence: 98%

Dynamic spatiotemporal gene expression in embryonic mouse thalamus

Suzuki-Hirano

Ogawa

Kataoka

et al. 2010

J of Comparative Neurology

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The anatomy of the mammalian thalamus is characterized by nuclei, which can be readily identified in postnatal animals. However, the molecular mechanisms that guide specification and differentiation of neurons in specific thalamic nuclei are still largely unknown, and few molecular markers are available for most of these thalamic subregions at early stages of development. We therefore searched for patterned gene expression restricted to specific mouse thalamic regions by in situ hybridization during the onset of thalamic neurogenesis (embryonic [E] days E10.5-E12.5). To obtain correct regional information, we used Shh as a landmark and compared spatial relationships with the zona limitans intrathalamica (Zli), the border of the p2 and p3 compartments of the diencephalon. We identified genes that are expressed specifically in the ventricular zone of the thalamic neuroepithelium and also identified a number of genes that already exhibited regional identity at E12.5. Although many genes expressed in the mantle regions of the thalamus at E12.5 showed regionally restricted patterns, none of these clearly corresponded to individual thalamic nuclei. We next examined gene expression at E15.5, when thalamocortical axons (TCAs) project from distinct regions of the thalamus and reach their targets in the cerebral cortex. Regionally restricted patterns of gene expression were again seen for many genes, but some regionally bounded expression patterns in the early postnatal thalamus had shifted substantially by E15.5. These findings reveal that nucleogenesis in the developing thalamus is associated with selective and complex changes in gene expression and provide a list of genes that may actively regulate the development of thalamic nuclei.

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Region‐specific gene expression in early postnatal mouse thalamus

Cited by 56 publications

References 49 publications

Molecular characterization of prosomeric and intraprosomeric subdivisions of the embryonic zebrafish diencephalon

Molecular characterization of prosomeric and intraprosomeric subdivisions of the embryonic zebrafish diencephalon

Comparative Anatomy of Marmoset and Mouse Cortex from Genomic Expression

Dynamic spatiotemporal gene expression in embryonic mouse thalamus

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